Sunday, May 19, 2013
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 | Differences Between Old and Young Mesenchymal Stem Cells for Drug Metabolism Andreas Nuessler, Eberhard-Karls University Tübingen, speaking at Stem Cells & Bioprocessing Europe 2012. |
 | Non-Coding RNA and Chromatin Remodeling: Epigenetic Control of Transcription Ingrid Grummt, German Cancer Research Center, speaking at Genomics Research Europe 2012 |
Outsourced Ion Channel Testing Trends 2013
HTStec
HTStec's Outsourced Ion Channel Testing Trends 2013 report was published on 3 May 2013. This 58 page market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on outsourced ion channel testing carried out in April 2013.
qPCR Assay Trends 2013
HTStec
HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Cellular Therapy and Cord Blood 2013 Market Report
Select Biosciences Ltd
This is the most up-to-date market report focusing on Cellular Therapy and the HSCT/Cord Blood Market Landscape, published by Select Biosciences.
Phenotypic Drug Discovery Trends 2013
HTStec
HTStec's Phenotypic Drug Discovery Trends 2013 report was published on 20 March 2013. This 59 page market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on phenotypic drug discovery (PDD) carried out in March 2013.
Mass-Spec Based Screening Assay Trends 2013
HTStec
This market report summarizes the results of HTStec's 1st industry-wide global web-based benchmarking survey on mass spectrometry (MS)-based screening assays carried out in February 2013.
Benchtop Automation Trends 2013
HTStec
This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on small-scale or benchtop automation carried out in January 2013.
Stem Cells in Research & Drug Discovery Trends 2012
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on stem cells in research and drug discovery carried out in November 2012.
Next-Gen Sequencing Trends 2012
HTStec
This market report summarizes the results of HTStec’s 3rd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in November 2012.
Bulk Reagent Dispenser Trends 2012
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on bulk reagent dispensers (BRDs) carried out in October 2012.
HTStec
HTStec's Outsourced Ion Channel Testing Trends 2013 report was published on 3 May 2013. This 58 page market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on outsourced ion channel testing carried out in April 2013.
qPCR Assay Trends 2013
HTStec
HTStec's qPCR Assay Trends 2013 report was published on 15 April 2013. This 63 page market report summarizes the results of HTStec's 3rd industry-wide global web-based benchmarking survey on real-time quantitative PCR (qPCR) assays and instruments carried out in March 2013.
Circulating Tumor Cells (CTCs) and Cancer Stem Cells (CSCs) Market Report 2013
Select Biosciences Ltd
This is the latest and most up-to-date Market Report from Select Biosciences addressing the CTC and CSC markets as they are evolving rapidly.
Cellular Therapy and Cord Blood 2013 Market Report
Select Biosciences Ltd
This is the most up-to-date market report focusing on Cellular Therapy and the HSCT/Cord Blood Market Landscape, published by Select Biosciences.
Phenotypic Drug Discovery Trends 2013
HTStec
HTStec's Phenotypic Drug Discovery Trends 2013 report was published on 20 March 2013. This 59 page market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on phenotypic drug discovery (PDD) carried out in March 2013.
Mass-Spec Based Screening Assay Trends 2013
HTStec
This market report summarizes the results of HTStec's 1st industry-wide global web-based benchmarking survey on mass spectrometry (MS)-based screening assays carried out in February 2013.
Benchtop Automation Trends 2013
HTStec
This market report summarizes the results of HTStec's industry-wide global web-based benchmarking survey on small-scale or benchtop automation carried out in January 2013.
Stem Cells in Research & Drug Discovery Trends 2012
HTStec
This market report summarizes the results of HTStec’s 2nd industry-wide global web-based benchmarking survey on stem cells in research and drug discovery carried out in November 2012.
Next-Gen Sequencing Trends 2012
HTStec
This market report summarizes the results of HTStec’s 3rd industry-wide global web-based benchmarking survey on next-generation sequencing (NGS) carried out in November 2012.
Bulk Reagent Dispenser Trends 2012
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on bulk reagent dispensers (BRDs) carried out in October 2012.
Nuvo Research Announces Scientific Presentation at the Annual Meeting of AAI
Data evaluating WF10's therapeutic impact on signs and symptoms of experimentally induced rheumatoid arthritis in mice.
An International Vision for Wheat Improvement
By 2050, a 60% increase in wheat production will be needed to meet the demand of a growing population.
Yale Cancer Center Carves New Path in Immunotherapy
Cancer immunotherapy is showing promise in treating patients with a variety of advanced, metastatic tumors.
UCSF Scientists Use Human Stem Cells to Generate Immune System in Mice
Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory.
App Helps Doctors, Students Learn to Diagnose Neurological Symptoms and Disease
The new app that presents a novel approach to learning the neurological physical exam, a challenging series of assessments aimed at diagnosing neurological disorders in patients.
Preclinical Tests Shows Agent Stops “Slippery” Proteins from Binding, Causing Ewing Sarcoma
Some tumors regressed to the point that cancer cells could not be detected microscopically.
Team Successfully Converts Human Skin Cells into Embryonic Stem Cells
The breakthrough marks the first time human stem cells have been produced via nuclear transfer and follows several unsuccessful attempts by research groups worldwide.
Results of the ROTAVAC Rotavirus Vaccine Study in India
Statement of Anthony S. Fauci, M.D. Director, National Institute of Allergy and Infectious Diseases National Institutes of Health.
Flu in Pregnancy May Quadruple Child’s Risk for Bipolar Disorder
NIH-funded study adds to evidence of overlap with Schizophrenia.
1H NMR Spectroscopic Quantification of Plasma Metabolites in Dialysate during Hemodialysis
Researchers from Tohoku University have examined the feasibility of using TSP as a quantitative standard of dialysate.
Data evaluating WF10's therapeutic impact on signs and symptoms of experimentally induced rheumatoid arthritis in mice.
An International Vision for Wheat Improvement
By 2050, a 60% increase in wheat production will be needed to meet the demand of a growing population.
Yale Cancer Center Carves New Path in Immunotherapy
Cancer immunotherapy is showing promise in treating patients with a variety of advanced, metastatic tumors.
UCSF Scientists Use Human Stem Cells to Generate Immune System in Mice
Raising hopes for cell-based therapies, UC San Francisco researchers have created the first functioning human thymus tissue from embryonic stem cells in the laboratory.
App Helps Doctors, Students Learn to Diagnose Neurological Symptoms and Disease
The new app that presents a novel approach to learning the neurological physical exam, a challenging series of assessments aimed at diagnosing neurological disorders in patients.
Preclinical Tests Shows Agent Stops “Slippery” Proteins from Binding, Causing Ewing Sarcoma
Some tumors regressed to the point that cancer cells could not be detected microscopically.
Team Successfully Converts Human Skin Cells into Embryonic Stem Cells
The breakthrough marks the first time human stem cells have been produced via nuclear transfer and follows several unsuccessful attempts by research groups worldwide.
Results of the ROTAVAC Rotavirus Vaccine Study in India
Statement of Anthony S. Fauci, M.D. Director, National Institute of Allergy and Infectious Diseases National Institutes of Health.
Flu in Pregnancy May Quadruple Child’s Risk for Bipolar Disorder
NIH-funded study adds to evidence of overlap with Schizophrenia.
1H NMR Spectroscopic Quantification of Plasma Metabolites in Dialysate during Hemodialysis
Researchers from Tohoku University have examined the feasibility of using TSP as a quantitative standard of dialysate.
GFT505 Reduces the Risk of Cardiovascular Events
Treatment with GFT505 significantly reduces the level of “remnant cholesterol”.
Curie-Cancer and Roche Strengthen Partnership
Curie-Cancer and Roche build on four years partnership by increasing translational research programs, speeding up development of new cancer treatments.
Merck KGaA and Quintiles Announce Innovative Clinical Development Partnership
Agreement creates unique strategic collaboration for development and clinical trial execution.
Algeta: FDA Approves Xofigo (radium-223 dichloride)
Xofigo shown in a pivotal phase III trial to significantly improve overall survival.
AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease
First selective JAK1 inhibitor to enter Phase 2 studies in Crohn's disease.
Olink Bioscience Appoints Sigma-Aldrich as Distributor of Duolink
Olink Bioscience will continue to develop the protein biomarker market.
Columbia Licenses Novel 3-D Organ and Tumor Segmentation Software to Varian Medical Systems
Allows for more precise and efficient planning and monitoring of cancer treatment.
Merck Serono and Quintiles Announce Innovative Clinical Development Partnership
Agreement creates unique strategic collaboration for development and clinical trial execution.
QPharma Appoints Chief Medical Officer
Dr. Shaw will oversee numerous initiatives, including QPharma’s QLaunch™ platform for maximizing the compliance and commercial effectiveness of life science product launches.
Biogen Idec Foundation Awards $250,000 to Develop Genetics Education Program
GenoExplorers seeks to introduce middle school students to genetics concepts through interactive learning.
Treatment with GFT505 significantly reduces the level of “remnant cholesterol”.
Curie-Cancer and Roche Strengthen Partnership
Curie-Cancer and Roche build on four years partnership by increasing translational research programs, speeding up development of new cancer treatments.
Merck KGaA and Quintiles Announce Innovative Clinical Development Partnership
Agreement creates unique strategic collaboration for development and clinical trial execution.
Algeta: FDA Approves Xofigo (radium-223 dichloride)
Xofigo shown in a pivotal phase III trial to significantly improve overall survival.
AbbVie and Galapagos Extend GLPG0634 Collaboration to Include Crohn's Disease
First selective JAK1 inhibitor to enter Phase 2 studies in Crohn's disease.
Olink Bioscience Appoints Sigma-Aldrich as Distributor of Duolink
Olink Bioscience will continue to develop the protein biomarker market.
Columbia Licenses Novel 3-D Organ and Tumor Segmentation Software to Varian Medical Systems
Allows for more precise and efficient planning and monitoring of cancer treatment.
Merck Serono and Quintiles Announce Innovative Clinical Development Partnership
Agreement creates unique strategic collaboration for development and clinical trial execution.
QPharma Appoints Chief Medical Officer
Dr. Shaw will oversee numerous initiatives, including QPharma’s QLaunch™ platform for maximizing the compliance and commercial effectiveness of life science product launches.
Biogen Idec Foundation Awards $250,000 to Develop Genetics Education Program
GenoExplorers seeks to introduce middle school students to genetics concepts through interactive learning.
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Microfluidic Sample Extraction Device with an Integrated Pressure Measurement
IMTEK, University of Freiburg
Bioanalytical applications, like the monitoring of metabolic processes, often require a continuous sample extraction. In this work we describe a microfluidic device which is able to subsequently extract samples in microliter range out of a continuous sample stream and provides an optional integrated channel for the measurement of the fluid pressure.
Concentration and Mixing Effects on the Production of Amine Hydrochloride Salts in a Confined Impinging Jet Reactor
University of Alberta
Results show that different AHC salts can be formed under different process conditions.
Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor
Dr. Hari Singh Gour University, Sagar
The objective of the present project is to develop transferrin coupled biodegradable nanoparticles (NPs) with high encapsulation efficiency (Doxorubicin). GALA (Glutamic acid-alanine-leucine alanine) a pH sensitive fusogenic endosomolytic peptide is added to the formulation to enhance the endosomal lysis that will further potentiate the delivery of anticancer drug inside tumor cell as well as prevent loss of drug via endosomes.
Highly Efficient Activated Carbon From Palm Shell as an Adsorbent of Toxin/Poison
International Islamic University Malaysia
Highly efficient activated carbon as an adsorbent of toxins has been successfully produced from palm shell through chemical activation process using phosphoric acid as activating agents.
Oral Health Management of a Patient with 47 XYY Syndrome
College of Dentistry, Salman bin Abdulaziz University
The 47XYY syndrome is an aneuploidy of sex chromosomes, where a human male receives an extra Y-chromosome making a total of 47 instead of the usual 46.
The Challenges of Relieving Cancer Pain: A Literature Review
NHS
This study aims to explore the discrepancy between the increasing array of treatments for cancer pain, as well as the evidence that it can be managed effectively in the majority of cases, and its persisting prevalence.
Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies
ReachBio LLC
This study aimed to assess if the CFC assay could also be useful at predicting the increased toxicity of drug combinations relative to the toxicity caused by the relevant single agent.
Predictive in silico Screening to Determine Vector-Mediated Transport Properties for the Blood-Brain Barrier Choline Transporter
University of Wurzburg
An attempt to analyze vector-mediated transport properties for the blood-brain barrier choline transporter (BBBCHT) was made to assess and improve drug delivery to the central nervous system.
Comparison of Dissociated Phoria Measuring Methods. Repeatability and Reliability
CBO
The aim of this study is to determine the reliability and compare reproducibility of different dissociated phoria measure tests.
Fast Liquid Differential Scanning Calorimetry (FLDSC)
Xensor Integration
Lysozyme experiments show that protein unfolding can be recorded at scan rates of up to 1000 °C/s, and for lysozyme concentrations of 1 % and probably even down to 0.1%.
IMTEK, University of Freiburg
Bioanalytical applications, like the monitoring of metabolic processes, often require a continuous sample extraction. In this work we describe a microfluidic device which is able to subsequently extract samples in microliter range out of a continuous sample stream and provides an optional integrated channel for the measurement of the fluid pressure.
Concentration and Mixing Effects on the Production of Amine Hydrochloride Salts in a Confined Impinging Jet Reactor
University of Alberta
Results show that different AHC salts can be formed under different process conditions.
Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor
Dr. Hari Singh Gour University, Sagar
The objective of the present project is to develop transferrin coupled biodegradable nanoparticles (NPs) with high encapsulation efficiency (Doxorubicin). GALA (Glutamic acid-alanine-leucine alanine) a pH sensitive fusogenic endosomolytic peptide is added to the formulation to enhance the endosomal lysis that will further potentiate the delivery of anticancer drug inside tumor cell as well as prevent loss of drug via endosomes.
Highly Efficient Activated Carbon From Palm Shell as an Adsorbent of Toxin/Poison
International Islamic University Malaysia
Highly efficient activated carbon as an adsorbent of toxins has been successfully produced from palm shell through chemical activation process using phosphoric acid as activating agents.
Oral Health Management of a Patient with 47 XYY Syndrome
College of Dentistry, Salman bin Abdulaziz University
The 47XYY syndrome is an aneuploidy of sex chromosomes, where a human male receives an extra Y-chromosome making a total of 47 instead of the usual 46.
The Challenges of Relieving Cancer Pain: A Literature Review
NHS
This study aims to explore the discrepancy between the increasing array of treatments for cancer pain, as well as the evidence that it can be managed effectively in the majority of cases, and its persisting prevalence.
Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies
ReachBio LLC
This study aimed to assess if the CFC assay could also be useful at predicting the increased toxicity of drug combinations relative to the toxicity caused by the relevant single agent.
Predictive in silico Screening to Determine Vector-Mediated Transport Properties for the Blood-Brain Barrier Choline Transporter
University of Wurzburg
An attempt to analyze vector-mediated transport properties for the blood-brain barrier choline transporter (BBBCHT) was made to assess and improve drug delivery to the central nervous system.
Comparison of Dissociated Phoria Measuring Methods. Repeatability and Reliability
CBO
The aim of this study is to determine the reliability and compare reproducibility of different dissociated phoria measure tests.
Fast Liquid Differential Scanning Calorimetry (FLDSC)
Xensor Integration
Lysozyme experiments show that protein unfolding can be recorded at scan rates of up to 1000 °C/s, and for lysozyme concentrations of 1 % and probably even down to 0.1%.
An Integrated Solution to Simplify Library Preparation and Multiplexing for NimbleGen Sequence Capture
Bioo Scientific
The studies described herein demonstrate the capability of Bioo Scientific’s novel NEXTFlex™ DNA Pre-Capture Combo Library construction kits used in conjunction with the NimbleGen Sequence Capture technology to obtain high coverage comparative genomic data from a panel of human HapMap DNA samples.
Direct Visualisation, Sizing and Counting of Aggregation in Proteins
NanoSight Ltd
Characterising the state of aggregation in proteins is of paramount importance when trying to understand biopharmaceutical product stability and efficacy. Product quality, both in terms of biological activity and immunogenicity can be highly influenced by the state of protein aggregation.
Direct Visualisation, Sizing & Counting of Viruses and Phages in Liquid Suspension
NanoSight Ltd
A new laser-based nanoparticle tracking analysis system is now available which allows nanoscale particles such as viruses and virus aggregates to be directly and individually visualised in liquids in real-time, from which high-resolution particle size distribution profiles can be obtained.
ORAC Assay for the Determination of Antioxidant Capacity in Foods
Tecan Group - Products
Measuring oxygen radical absorbance capacity with the Infinite® 200 PRO multimode reader.
Automated Growth Monitoring of Microaerophilic Organisms
Tecan Group - Products
Walkaway growth monitoring of Helicobacter pylori in the Infinite® 200 PRO reader with Gas Control Module (GCM™).
Rapid Critical Micelle Concentration (CMC) Determination Using Fluorescence Polarization
BioTek Instruments
The determination of the critical micelle concentration (CMC) value of surfactants under different environmental conditions is important for a number of different biological and chemical processes. Because the CMC is not a constant value, shifting with different environmental conditions, it is important that a rapid, reliable and easy methodology be available to facilitate testing.
Analysis of a New High Throughput Screening Detection Technology for Rapid hERG Safety Testing using a Fluorescence Polarization Assay
Biotek Instruments
Support Synergy™ Neo launch by providing speed and sensitivity data for Fluorescence Polarization detection mode in low volume 384-well plate using hERG biochemical assay as a Model.
BRD4 Bromodomain 1 Inhibitor Screening Using a Homogeneous Proximity Assay
BioTek Instruments
Demonstration of profiling and primary screening of an epigenetic target; a histone acetylating bromodomain. This is a TR-FRET based application highlighting the use of automated instrumentation and a high-throughput screening (HTS) multi-mode microplate reader.
Integration of Liquid Handler Quality Control Into the HTS Daily Routine
Artel
This application note describes how the Artel MVS® Multichannel Verification System can be used to assess the performance of the liquid handlers integrated into a PerkinElmer cell::explorer high throughput screening (HTS) system.
Purification of Genomic DNA from Saliva Using Oragene® Discover Collection Kits and the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling Workstation
Hamilton
In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
Bioo Scientific
The studies described herein demonstrate the capability of Bioo Scientific’s novel NEXTFlex™ DNA Pre-Capture Combo Library construction kits used in conjunction with the NimbleGen Sequence Capture technology to obtain high coverage comparative genomic data from a panel of human HapMap DNA samples.
Direct Visualisation, Sizing and Counting of Aggregation in Proteins
NanoSight Ltd
Characterising the state of aggregation in proteins is of paramount importance when trying to understand biopharmaceutical product stability and efficacy. Product quality, both in terms of biological activity and immunogenicity can be highly influenced by the state of protein aggregation.
Direct Visualisation, Sizing & Counting of Viruses and Phages in Liquid Suspension
NanoSight Ltd
A new laser-based nanoparticle tracking analysis system is now available which allows nanoscale particles such as viruses and virus aggregates to be directly and individually visualised in liquids in real-time, from which high-resolution particle size distribution profiles can be obtained.
ORAC Assay for the Determination of Antioxidant Capacity in Foods
Tecan Group - Products
Measuring oxygen radical absorbance capacity with the Infinite® 200 PRO multimode reader.
Automated Growth Monitoring of Microaerophilic Organisms
Tecan Group - Products
Walkaway growth monitoring of Helicobacter pylori in the Infinite® 200 PRO reader with Gas Control Module (GCM™).
Rapid Critical Micelle Concentration (CMC) Determination Using Fluorescence Polarization
BioTek Instruments
The determination of the critical micelle concentration (CMC) value of surfactants under different environmental conditions is important for a number of different biological and chemical processes. Because the CMC is not a constant value, shifting with different environmental conditions, it is important that a rapid, reliable and easy methodology be available to facilitate testing.
Analysis of a New High Throughput Screening Detection Technology for Rapid hERG Safety Testing using a Fluorescence Polarization Assay
Biotek Instruments
Support Synergy™ Neo launch by providing speed and sensitivity data for Fluorescence Polarization detection mode in low volume 384-well plate using hERG biochemical assay as a Model.
BRD4 Bromodomain 1 Inhibitor Screening Using a Homogeneous Proximity Assay
BioTek Instruments
Demonstration of profiling and primary screening of an epigenetic target; a histone acetylating bromodomain. This is a TR-FRET based application highlighting the use of automated instrumentation and a high-throughput screening (HTS) multi-mode microplate reader.
Integration of Liquid Handler Quality Control Into the HTS Daily Routine
Artel
This application note describes how the Artel MVS® Multichannel Verification System can be used to assess the performance of the liquid handlers integrated into a PerkinElmer cell::explorer high throughput screening (HTS) system.
Purification of Genomic DNA from Saliva Using Oragene® Discover Collection Kits and the Akonni TruTip® Extraction System on the Hamilton Microlab® STAR Liquid Handling Workstation
Hamilton
In the following studies, we have demonstrated the high precision of the automated TruTip extraction technology in processing genomic DNA from low-volume saliva samples and its advantage over competitors.
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