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Magneto-plasmonic Nanoparticle Platform ... Multiplexed Assays for Diagnostics and ...Repurposing Approaches for Rare and Negl...

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Webcasts
Webinar: How to Overcome Assay Challenges Using Custom Recombinant AntibodiesWebinar: How to Overcome Assay Challenges Using Custom Recombinant Antibodies
Join this webinar to find out how custom-made recombinant antibodies can solve your challenges when designing and optimizing critical assays to support drug development, diagnostic assays or discovery studies.
Pivot Park Screening Centre, The Pivot for Screening Knowledge and ExpertisePivot Park Screening Centre, The Pivot for Screening Knowledge and Expertise
Helma Rutjes, Pivot Park Screening Centre, speaking at Drug Discovery and Development 2014

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Gene Expression Analysis Market by Technology, Consumables, Services & Applications - Global Forecast to 2018
MarketsandMarkets

Over the years, the gene expression analysis market, comprising of instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of gene expression applications.
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
High Throughput Screening (HTS) Market by Technology, Applications, and End Users - Forecast to 2018
MarketsandMarkets

Technological advancements and flourishing outsourcing industry likely to propel the growth of the global high throughput screening market. In this report, the global high throughput screening market has been segmented on the basis of technology, products, applications, end users, and geography.
Chromatography Resin Market by Application, Techniques & Type - Trends & Forecast to 2018
MarketsandMarkets

The chromatography resin market is expected to grow at a decent pace during the coming decade driven by its increasing application in monoclonal antibody production and food analytics.
Chromatography Accessories and Consumables Market by Types, Technology & End-users - Trends & Global Forecasts to 2018
MarketsandMarkets

The chromatography accessories and consumables market demands significant investments in R&D in order to constantly come up with new and innovative products and technologies.
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Scientific News
Researchers Identify Non-Gluten Proteins as Targets of Immune Response to Wheat in Celiac Disease
The results were reported online in the Journal of Proteome Research.
New Research Unlocks a Mystery of Albinism
A team led by Brown University biologists has discovered the way in which a specific genetic mutation appears to lead to the lack of melanin production underlying a form of albinism.
Predicting Sepsis
Altered white-blood-cell motion in burn patients may warn of infection.
Study Finds Genetic Clue To Menopause-Like Condition In Young Women
NIH-funded research may also contribute to understanding normal menopause.
Stem Cells Faulty In Duchenne Muscular Dystrophy
In a mouse model of Duchenne muscular dystrophy, muscle stem cells express connective-tissue genes associated with fibrosis and muscle weakness, according to a new study.
How Breast Cancer Cells Break Free To Spread In The Body
Analysis of the downstream signaling pathways of a gene called SNAIL could be used to identify potential targets for scientists who are looking for ways to block or slow metastasis.
Multiple Allergic Reactions Traced To Single Protein
Points to new strategy to reduce allergic responses to many medications.
Cutting Out the Cellular Middleman
New technology directly reprograms skin fibroblasts for a new role.
Therapeutic Strategy May Treat a Childhood Neurological Disorder
Researchers have identified a possible therapy to treat neurofibromatosis type 1 or NF1.
Novel Agent Decreases Neuropathic Pain in Patients with Type 2 Diabetes
Promising profile of disease modification and pain reduction leads to proof of concept trials.
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Business News
Making Single-Cell Biology Work
New collaboration between EMBL-EBI, the Wellcome Trust Sanger Institute and Fluidigm keeps research and technology on the cutting-edge of single-cell genomics.
Spinnovation Receives Good Manufacturing Practices Certification
Certification for testing drug substances and drug products to support market release.
Baxter to Divest Vero Cell Vaccines Platform to Nanotherapeutics
Agreement includes all assets related to the platform, including vaccines for H5N1, H1N1 and seasonal influenza.
Actavis Announces Proposed Senior Leadership Team
Leadership reflects exceptional combined expertise of Actavis and Allergan.
Halozyme Enters a Global Collaboration with Janssen
Collaboration to develop and commercialize subcutaneous products using ENHANZE™ technology.
X-Chem and Alexion Collaborate
X-Chem to discover small molecule drug candidates for global development by Alexion.
Curie-Cancer and GamaMabs Pharma Renew their Research Partnership
Clinical trials are scheduled for 2015 to explore the value of the candidate drug 3C23K in relapsing ovarian cancer.
BioLineRx and Major Global Pharmaceutical Company Form Strategic Collaboration
Global pharmaceutical company makes initial $10 million equity investment in BioLineRx.
14M Genomics and Syncona Sign £12.5m Financing
14M Genomics and Syncona sign £12.5 million financing to develop cancer genomic diagnostics in partnership with the Wellcome Trust Sanger Institute.
New Research Leader Joins TGAC and TSL
Ksenia Krasileva joins The Genome Analysis Centre’s (TGAC) Science Faculty to lead the Institute’s new Triticeae Genomics Group, in joint appointment with The Sainsbury Laboratory (TSL).
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Events
BIT
25 Apr 2015
BIT's 7th Annual International ...
Plant and Animal Genome XXIII
10 Jan 2015
Plant and Animal Genome XXIII ...
Biomarkers from Research to Cl
15 Jan 2015
Biomarkers from Research to Cl ...
Microbiome Forum Asia
19 Jan 2015
Microbiome Forum Asia ...

ePosters
Non-disruptively Count and Quantify Fluorescent iPS Colonies During Secondary Reprogramming: 7 min per 6-well Plate, Dual-fluorescence Whole Well Imaging Cytometry
Nexcelom Bioscience; University of Edinburgh

Nexcelom’s Celigo imaging cytometer has been applied to provide automated, rapid assessment of iPS reprogramming.

Progressing 3D Spheroid Analysis into a HTS Drug Discovery Method
Nexcelom Bioscience, LLC

This study demonstrates that the cell culture assay for tumorsphere size was successfully adapted to 384-well plate for a 3D spheroid assay using U-bottom low attachment 384-well and the Celigo Automated Imager for image acquisition and analysis. Moreover, the utilization of an imager provided insight on sphere and cell fate after long term drug treatment.
Forced Degradation Study of Expired and Marketed Tablets of Amlodipine by RP-HPLC
Institute of Pharmaceutical Education and Research, Borgaon (Megeh), Wardha

The objective of the current study was to develop simple, accurate, sensitive and stability indicating RP-HPLC method for the determination of per cent drug remained of Amlodipine besylate in the presence of its degradation products in bulk drug, expired tablets and tablets whose expiry date has not been exceeded.
LC-MS/MS METHOD FOR THE QUANTIFICATION OF PITOFENONE IN HUMAN PLASMA
Department of Pharmaceutical Chemistry, JSS College of Pharmacy, JSS University, Mysore – 570 015, Karnataka, India

We developed LCMS/MS bioanalytical method for quantitative estimation of Pitofenone HCl in plasma is simple, sensitive, accurate, precise, and selective. Percentage recovery shows that the method is free from interference of matrix. The analytical method presented here has proved to be useful for investigation of the characteristics of Pitofenone in human plasma in pharmacokinetic and pharmacogenetic studies.
Using An in‐vitro Human Airways Model to Study the Effects of e‐cigarettes on Bronchial Epithelial Cells
1 School of Engineering and Applied Science, Aston University, Birmingham UK; 2 School of Health and Life Sciences, Aston University, Birmingham UK

The prime aim of our study is to use in-vitro human airway models as an effective alternative to replace animals in traditional/E-cigarette research.
Experimental Evolution in Diatoms - Thermal longterm acclimation in two model diatom species
1 University of East Anglia, School of Environmental Science, Norwich, UK 2Institute of Evolutionary Biology, University of Edinburgh, Kings Building, Ashworth Laboratories, West

Experimental Evolution in two model Diatoms
Microelectrodes for Microdroplet Motion Based On Electrowetting: A Review on Design
Micro and Nano Electronic Systems Unit (MiNES), Department of Electrical and Electronic Engineering, Faculty of Engineering, Universiti Putra Malaysia, 43400 Serdang Selangor.

The technology is growing rapidly whereby the researchers all over the world have discovered the smaller scale of technology. In micro-nanotechnology, the microfluidic manipulation become useful in many field of applications and one of the most advanced method is electrowetting. The observation and review on the design of microelectrode for droplet motion based on electrowetting with different shapes, sizes and fabrication regarding on the different application are hereby reported.
Real Time Dual-Channel Multiplex SERS Ultradetection
University of Cambridge

Real time On-line multiplex SERS detection in a microfluidic device.
Antioxidant and Free Radicals Scavenging Activity of Biomolecules: Hydroxamic Acids
School of Study in Chemistry, Pt. Ravishankar Shukla University, Raipur-492010, Chhattisgarh, India

In the present poster attention is focused towards the investigation of antioxidant and free radicals scavenging activity of N-aryl substituted hydroxamic acids by DPPH method which is based on the reduction of alcoholic DPPH solutions in presence of a hydrogen donating antioxidant, hydroxamic acids.
"In-vitro studies on hydroxamic acid- CT DNA binding"
Research Scholar

In vitro studies of five the interaction between five different derivatives of hydroxamic acids, N-phenyl 2,4dichloro phenoxybutyro, N-m-tolyl 2,4 dichlorophenoxyglutero, N-m-tolyl-4-chlorophenoxyaceto, N-m-chloro-phenyl-tertiarybutylbenzo and N-p-tolyl-iso-valero hydroxamic acids and calf thymus DNA was investigated under simulated physiological condition.
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Application Notes
Pharmaceutical Excipient Characterization
Malvern Instruments Limited


Quantifying shear thinning behavior on a rotational rheometer using the power law model
Malvern Instruments Limited

This application note shows how the power law model can be used to quantify shear thinning behavior and for comparing between products and formulations.
Quantifying viscosity recovery following extrusion or spraying using thixotropy assessment on a rotational rheometer
Malvern Instruments Limited

This app note shows how a three step shear rate test can be used to evaluate the extent of viscosity recovery following extrusion from a tube or bottle.
Interfacing Viscotek detectors with Waters SEC systems and Waters Empower® software
Malvern Instruments Limited

This technical note describes how to connect Viscotek detectors to Waters systems, in particular the Waters Alliance® system, and how to use OmniSEC in combination with Empower® to run trouble-free separation sequences.
Measuring protein molecular weight using the Viscotek SEC-MALS 20 connected to a Waters Empower® SEC system
Malvern Instruments Limited

In this application note, we show that Malvern’s OmniSEC software can now communicate with Waters Empower® for the seamless exchange of sample sequences. A selection of proteins was used to demonstrate the measurement of protein molecular weight, oligomeric and aggregation state.
Measuring Exosome Stability with Nanoparticle Tracking Analysis
Malvern Instruments Limited

Here, an LM10 is used to measure the size and concentration of exosomes after storage at two different temperatures, 4°C and room temperature.
Approaching Single-Cell Sequencing by Understanding NGS Library Complexity and Bias
Swift Biosciences Inc

This application note describes the sequence coverage performance andp reservation of molecular complexity of next generation sequencing (NGS) libraries generated from human and microbial genomic DNA using the Accel-NGS™ 2S DNA Library Kit for whole-genome sequencing (WGS) on the Illumina® platform.
Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry
Malvern Instruments Limited

DSC data is useful in predicting the stability of a protein in solution. The Tm indicates thermostability, and Tm determination in different formulations is an approximate measure of the susceptibility to aggregation and other irreversible changes at lower temperatures.
Assessing Drug Encapsulation Efficiency using Nanoparticle Tracking Analysis
Malvern Instruments Limited

In this application note we describe the use of Nanoparticle Tracking Analysis (NTA) for size and concentration measurements of drug delivery nanoparticles. In addition, by using a fluorescently tagged drug molecule, it was possible to determine how many drug delivery nanoparticles had successfully been loaded with drug molecules.
GPC Characterization of Nylon using Formic Acid for Reduced Cost per Analysis
Malvern Instruments Limited

GPC/SEC can be used to characterize commodity or bulk manufactured polymers. Here we describe how the use of formic acid instead of HFIP as the dissolution solvent and/or mobile phase can lead to improvements in both cost per analysis and health and safety
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