Auxilium Pharmaceuticals, Inc. Announces First Patients Dosed in XIAFLEX® Phase Ib Cellulite Study
The objectives of the study are to assess the safety, effectiveness, and pharmacokinetics of XIAFLEX for the treatment of EFP.

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Neonatal Respiratory Distress Syndrome Treatment Comparison Shows Lower Mortality Rates
New analysis published in eFirst pages of Pediatrics website also shows reduced need for redosing when using CUROSURF Intratracheal Suspension.

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Aria Announces Publication of Independent Study in the American Journal of Obstetrics & Gynecology Using Aria's Technology
Study, which exclusively examines women in their first trimester of pregnancy, provides largest data set to date for trisomy 18 pregnancies.

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Vitamins could lead to the Design of Novel Drugs to Combat Malaria
The research will enable scientists to learn more about the nature of the enzymes required for vitamin biosynthesis by the malaria causing pathogen Plasmodium.

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Pinpoint Genomics Announces Publication of Clinical Study Results in Lung Cancer
The Pinpoint Dx Lung(TM) Assay is a molecular diagnostic assay that assesses the likelihood of death after lung cancer surgery.

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Cambridge Team First to Grow Smooth Muscle Cells from Patient Skin Cells
This work could lead to new treatments and better screening for cardiovascular disease.

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Dundee Researchers Seek to Beat "Molecular Obesity"
Researchers from the University of Dundee have come up with a new innovative approach in the quest to reduce failure rates in the drug discovery process.

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Cannabis Science Updates Latest Cancer Patient Treatment
The U.S. biotech company developing pharmaceutical cannabis (marijuana) products, announced new remarkable photographic updates of the 3rd cancer patient, with treatment-resistant squamous cell carcinoma on his head.

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Van Andel Study Provides New Details of Fundamental Cellular Process
Study of plant hormone could have far-reaching implications for cell biology and disease research.

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DIMming Cancer Growth - STAT: diindolylmethane Suppresses Ovarian Cancer
New research published in BioMed Central’s open access journal BMC Medicine has looked in detail at the action of DIM and showed that it works by blocking the activation and production of the transcription factor STAT3.

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Get Ready for SLAS 2012
The upcoming Society for Laboratory Automation and Screening (SLAS) conference looks to provide an interesting new take on the previous LabAutomation and SBS conferences in its inaugural combined format. The conference launches from the San Diego Convention Center, the original site of the LabAutomation conferences, from February 4-8, 2012 with an enhanced program that subtly shifts from the previous one.

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Rhenovia Pharma Opens First US Office
Deployment will widen use of biosimulation technology.

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Sandoz Initiates Two More Phase III Biosimilar Trials
Latest milestones reinforce long-term global leadership commitment.

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Acsis, Inc. Appoints Paul Allen to Board of Directors
VP of Strategic Services at Olson Research Group adds vast experience to Acsis, Inc.'s board.

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Stellar Pharmaceuticals Receives 2nd Uracyst(R) Patent in United States of America
The patent is for intellectual property central to one of the company's lead products, Uracyst(R), used in the treatment of interstitial cystitis/painful bladder syndrome.

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Marina Biotech Starts Cohort 2 of its Phase 1b START-FAP Clinical Trial of CEQ508
Data review committee determines CEQ508 well tolerated in cohort 1 patients.

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Belgium hosts the International Conference: Graphene 2012
The International Conference on Graphene will be held in Brussels (Belgium), from April 10-13 at the Brussels44Center.

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OctoPlus Announces the Proposal to Appoint Staf Van Reet to the Supervisory Board
Dr. Staf Van Reet appointed as chairman of the Supervisory Board.

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Lpath Temporarily Suspends Dosing of iSONEP Due to cGMP Compliance Issues
Management to Host Investor Conference Call Friday, January 27.

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Oryzon to Present at 4th CHI X-Gen Congress, Epigenetics, Targets and Therapies
Dr. Tamara Maes, will present under the title “Development of Novel, Potent LSD1 Inhibitors and Their In Vitro and In Vivo Effects on Tumor Cell Growth, on March 6th.

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Ion Chromatography ICP-Q-MS for the Detection of Arsenic Species in Apple Juice
Thermo Scientific

Interest in the determination of Arsenic species in fruit juices has been triggered by recent media reports in the United States claiming that some apple juices may contain high amounts of Arsenic. Inorganic forms of Arsenic (As3+ and As5+) are highly toxic, whereas the organic forms (e.g. arsenobetaine) are not considered toxic. A robust IC-ICP-MS system was developed and shown to be a highly selective and sensitive technique for determination of trace element species.

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High Content Analysis of Neural Stem Cell Expansion and Differentiation
Molecular Devices

Automated assay methods for monitoring neural stem cell expansion and differentiation using stem cell derived neural cell lines and high content imaging systems have been described.

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Modeling Disposition of Sotalol following Intravenous and Oral Administration in Healthy Adult Subjects
Simulations Plus

Sotalol is a non specific adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmia. Its absorption, distribution and systemic PK or, collectively, ‘disposition’ was modeled and simulated using GastroPlus™ v7.0. Biopharmaceutical properties were obtained from in silico predictions and in vitro measurements.

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Predicting hERG Potassium Channel Affinity with Artificial Neural Network Ensembles
Simulations Plus

Modeling hERG inhibition has gained significant popularity since 2005, when the FDA recognized the correlation between hERG inhibition and a prolonged QT interval by issuing guidance for the evaluation of new non-antiarrythmic drugs against the hERG channel.Long QT syndrome or LQTS is a risk factor for ventricular tachyarrhythmias and sudden death.

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Predicting Sites of Metabolism with Artificial Neural Network Ensembles
Simulations Plus

Hepatic first-pass metabolism of many drugs and pro drugs plays a key role in their oral bioavailability. The human cytochrome P450 enzymes are responsible for the metabolism of most drugs. Knowledge of likely sites of metabolic attack in a drug molecule can aid in designing out unwanted metabolic liabilities early on in the drug discovery process, as well as in the design of pro drugs where metabolic transformation is desired.

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Influenza A (H1N1) Transmission in Andhra Pradesh, India
MNR Medical college

The spread of highly pathogenic influenza A (H1N1) virus has posed a serious threat to human community in several regions of the world including India, and has created an immediate need for effective prevention strategies against the pandemicity of the disease. The present study gives a comprehensive picture of spread of H1N1 cases in Andhra Pradesh during 2009 and 2010, from the daily notification data.

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Hot Start Amplification using OligoBeads via Gradual Release of Bound Primers
CTGen

OligoBeads provide a mean to store normalized primers used in performing enzymatic reactions including PCR. Primer bound beads eliminate the potential for pipeting errors and reduce contamination thus yielding lower repeat rates and less reagent wastage. The primers bound to the OligoBeads can be stored over a period of a few months without degradation in a nuclease free environment.

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Novel colorimetric detection method for the cost-effective identification of influenza on a low-density microarray
InDevR

The presented work explores the use of ampliPHOX, a rapid, cost-effective, field-amenable colorimetric detection method, combined with the FluChip low-density microarray for screening and surveillance of influenza viruses, particularly in resource-limited settings. Analysis of microarray data from over 100 influenza samples confirmed the ability to easily distinguish influenza A and B and produce unique array patterns for a wide variety of influenza A subtypes.

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UBS109, a novel curcumin analogue, promotes apoptosis in Head and Neck cancer cells through activating death receptor signaling pathway
Emory Chemical Biology Discovery Center

UBS109, a new curcumin analogue, exhibited a potent anticancer activity, inhibiting colony formation and cancer cell growth in vitro, and tumor growth in a xenograft animal model in vivo. 2. UBS109 rapidly blocks the NF-?B signaling pathway through the

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SFC Fluidics Microfluidic ePump Technology Ideal for Point of Care Diagnostics
SFC Fluidics LLC

True Point of Care medical devices place unique demand on micropump characteristics. SFC Fluidics ePump is an innovative electrochemical pumping system that is different from other microfluidic pumps.

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Two-Dimensional HPLC Combined with On-Line SPE for Determination of Sudan Dyes I–IV in Chili Oil
Dionex - Part of Thermo Fisher Scientific

Although use of Sudan dyes in food is restricted, they are nevertheless sometimes added to foods to improve the appearance and command a higher price. Because Sudan dyes may create health problems such as genotoxic and carcinogenic effects, concerns over contamination of Sudan dyes has increased awareness and testing for these compounds.

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Fast Determination of Anthocyanins in Pomegranate Juice
Thermo - Part

Due to their strong antioxidant properties, anthocyanins are of considerable interest. Pomegranate juice (PJ) has been reported to contain 3× more antioxidant activity than green tea. Due to the high demand for pomegranates, adulteration of PJ has become widespread. Manufacturers have attempted to extend the limited supply by blending with filler ingredients such as cane sugar, corn syrup sweeteners, and lower-quality juices containing sorbitol, malic acid, and sucrose.

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Analysis of Fruit Juice Adulterated with Medium Invert Sugar from Beets
Dionex - Part of Thermo Fisher Scientific

Fruit juice adulteration presents an economic and regulatory problem. The United States orange juice industry estimates that orange juice sales gross more than one billion dollars annually. The most common forms of adulteration include simple dilution and blending of inexpensive and synthetically produced juices into the more expensive ones.

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Kv1.5 Potassium Channel Assay Using the IonWorks HT System
Molecular Devices

This application note describes the use of the IonWorks HT Platform with a voltagedependent potassium channel Kv1.5.

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Contaminant bovine IgG assay
Molecular Devices

Fetal calf serum containing bovine IgG is commonly used in mammalian cell culture media for the production of recombinant pharmaceuticals. During the purification process of a recombinant pharmaceutical, bovine IgG may be copurified with the product, and may represent a biological hazard for clinical use. Therefore, it may be necessary to assay for contaminant bovine IgG in a final product originating from mammalian cells.

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Applications of rapid immunoassays (FAST ILA) in cell culture/fermentation and process development using the Threshold System
Molecular Devices

Accurate measurement of the concentration of a biological product is important in bioreactor/fermenter monitoring, downstream processing and final product quality control. Currently, electrophoretic, chromatographic and immunochemical methods are the most commonly used. These three methods are currently used in combination to provide the desired sample information.

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Dual-Glo Luciferase Reporter-Gene Assay on the SpectraMax M5, LMax II384 and Analyst GT Microplate Readers
Molecular Devices

Reporter-gene assays are used to study eukaryotic gene expression. Dual genetic reporters are commonly used in transient transfections of cultured cells to minimize experimental variability. Recently, Promega introduced a Dual-Glo Lucoferase assay system which replaced the outdated ‘flash’ assays used previously. Ensuring both genetic reporters have different substrate requirements enables them to be detected using a single reaction mixture.

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Sequence-Specific DNA Assay
Molecular Devices

The Threshold® system from Molecular Devices, together with the Immuno Ligand Assay (ILA) kit can be used to measure specific DNA sequences. Biotinylated or fluorescienated oligonucleotide probes, specific to the target sequence, anneal to the digested target DNA creating a probe-target hybrid which can then be detected and quantified against a standard curve, with pleasing results.

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Measurement of Proteasome Inhibition in Live Cells in Molecular Devices Microplate Fluorometers
Molecular Devices

The proteasome is a massive protein complex which can recognize and bind targeted proteins, and inject them into the central core where the proteins are successively degraded into short peptides. Whereas protein synthesis is well-understood after decades of study, major advances in our knowledge of protein degradation have occurred only in the last two decades.

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Recording of ICRAC in RBL-1 Cells on the PatchXpress 7000A Automated Patch Clamp System
Molecular Devices

Calcium release-activated calcium (CRAC) channels play an important role in intracellular Ca2+ homeostasis. Like other store-operated calcium channels, currents through the CRAC channel (ICRAC) are activated by depletion of calcium in the endoplasmic reticulum (ER) and serve the purpose of slowly replenishing the ER with Ca2+.

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