Life Technologies Signs Licensing Agreement with Suzhou Ribo Life Sciences
Agreement formed for the development of potent siRNA therapeutics in China.

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Researchers Track Cardiac Regeneration on Cellular Level
New study visually monitored the dynamic cellular events that take place when cardiac regeneration occurs in zebrafish after cardiac ventricular injury.

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UCSF Steps Forward to Lead Advances in Precision Medicine
The world’s foremost thinkers, creators and innovators convened last month to identify new approaches and spur action to make medicine more predictive, preventive and precise.

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Early-life Air Pollution Linked with Childhood Asthma in Minorities, in Study
Research by UCSF team indicates that traffic-related pollution might be a cause.

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Pesticides Significantly Reduce Biodiversity in Aquatic Environments
Current pesticide risk assessment falls short of protecting biodiversity.

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Using Mathematical Modelling in the Fight Against Cancer
Different treatments and genetic modifications might allow cancer-killing, oncolytic viruses to overcome the natural defences that cancer cells use.

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Expelled DNA that Traps Toxins May Backfire in Obese
The body’s most powerful immune cells may have a radical way of catching their prey that could backfire on people who are overweight.

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Developing Cancer Drugs
Researchers find therapeutic potential in ‘undruggable’ target.

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Memory-Boosting Chemical Is Identified in Brains of Mice
UCSF cell biologists find molecule targets a key biological pathway.

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Aspirin May Fight Cancer by Slowing DNA Damage
UCSF-led study of patients with pre-cancerous conditions probed NSAID effects on mutation rate.

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STAT-Diagnostica Appoints Board Chairman
Company names Gérard Vaillant as chairman of the company’s board of directors.

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Therapure Biopharma Awarded US Government Contract
DoD contract to manufacture materials for anti-nerve gas agent.

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MHRA Approval for CDMO’s Commercial Facility
To supply licensed commercial products and aid clinical projects.

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Phyton Biotech Receives CEP for Docetaxel API
Helps alleviate docetaxel shortage through plant cell fermentation process.

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Impact Analytical Opens New Laboratory Facility
Expands capacity by more than 20%.

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Protalix and Brazil's Ministry of Health Enter into Technology Transfer Agreement
Exclusive license and supply agreement with Pfizer amended to facilitate the technology transfer.

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TKL Research is Building New Clinical Research Facility in Fair Lawn, N.J.
New facility include a 30-bed, Phase 1 unit as well as multiple, outpatient clinical examination rooms.

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New Metals Lab Opens
Company sign laboratory partnership agreement with Agilent.

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LabSmith Products Now Distributed in China by BYEC
R&D scientists now access an expansive range of tools for lab-on-chip experiments.

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BioCision Announces Two New U.S. Patents for Thermo-Conductive Products
New patents awarded for CoolSink® Plate Modules and ThermalTray™ Platforms.

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Function of Protein Kinase C-1 in memory in Caenorhabditis elegans
Routtenberg Labs

To study long lasting olfactory memory in C. elegans, we conditioned the nematodes to form an association between the odorant benzaldehyde and starvation.

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Microfluidic Sample Extraction Device with an Integrated Pressure Measurement
IMTEK, University of Freiburg

Bioanalytical applications, like the monitoring of metabolic processes, often require a continuous sample extraction. In this work we describe a microfluidic device which is able to subsequently extract samples in microliter range out of a continuous sample stream and provides an optional integrated channel for the measurement of the fluid pressure.

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Concentration and Mixing Effects on the Production of Amine Hydrochloride Salts in a Confined Impinging Jet Reactor
University of Alberta

Results show that different AHC salts can be formed under different process conditions.

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Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor
Dr. Hari Singh Gour University, Sagar

The objective of the present project is to develop transferrin coupled biodegradable nanoparticles (NPs) with high encapsulation efficiency (Doxorubicin). GALA (Glutamic acid-alanine-leucine alanine) a pH sensitive fusogenic endosomolytic peptide is added to the formulation to enhance the endosomal lysis that will further potentiate the delivery of anticancer drug inside tumor cell as well as prevent loss of drug via endosomes.

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Highly Efficient Activated Carbon From Palm Shell as an Adsorbent of Toxin/Poison
International Islamic University Malaysia

Highly efficient activated carbon as an adsorbent of toxins has been successfully produced from palm shell through chemical activation process using phosphoric acid as activating agents.

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Oral Health Management of a Patient with 47 XYY Syndrome
College of Dentistry, Salman bin Abdulaziz University

The 47XYY syndrome is an aneuploidy of sex chromosomes, where a human male receives an extra Y-chromosome making a total of 47 instead of the usual 46.

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The Challenges of Relieving Cancer Pain: A Literature Review
NHS

This study aims to explore the discrepancy between the increasing array of treatments for cancer pain, as well as the evidence that it can be managed effectively in the majority of cases, and its persisting prevalence.

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Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies
ReachBio LLC

This study aimed to assess if the CFC assay could also be useful at predicting the increased toxicity of drug combinations relative to the toxicity caused by the relevant single agent.

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Predictive in silico Screening to Determine Vector-Mediated Transport Properties for the Blood-Brain Barrier Choline Transporter
University of Wurzburg

An attempt to analyze vector-mediated transport properties for the blood-brain barrier choline transporter (BBBCHT) was made to assess and improve drug delivery to the central nervous system.

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Comparison of Dissociated Phoria Measuring Methods. Repeatability and Reliability
CBO

The aim of this study is to determine the reliability and compare reproducibility of different dissociated phoria measure tests.

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New Approach to Determine Time since Deposition of Blood at Crime Scenes
IMPLEN

So far, there is no generally accepted procedure available that enables forensic scientists to determine the age of blood stains at a crime scene. Present methods are either limited in their predictive power or their analytical sensitivity.

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Validating the Expression Consistency of a Housekeeping Protein
Bio-Rad Laboratories

Housekeeping proteins (HKP) are typically used as loading controls because it is assumed that the HKP expression level remains consistent across samples. However, there is evidence that HKP expression levels change in many scenarios, including siRNA treatment, cell death, cell differentiation, etc.

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A Method for Greater Reliability in Western Blot Loading Controls: Stain-Free Total Protein Quantitation
Bio-Rad Laboratories

Reliable assessment of changes in target protein levels by western blot requires measurement of both the target and loading control proteins in the linear dynamic range. Stain-free technology is a novel method introduced by Bio-Rad to visualize and quantify proteins in gels and blots.

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General V3 Western Blotting Protocol
Bio-Rad Laboratories

Western blotting is a very useful and widely adopted lab technique, but the traditional procedure can be long and tedious. Researchers can assess only whether a blot image is captured at the end of the long procedure and the quality of western blot data is sometimes challenged due to poor loading controls.

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Determining the Appropriate Sample Load When Using a Stain-Free V3 Western Workflow™
Bio-Rad Laboratories

Traditional western blot workflows require an appropriate sample load to detect both target proteins and loading control proteins. The discrepancy between these quantities often leads to oversaturated protein bands, forcing researchers to sometimes run two duplicate gels or titrate down the antibody concentration in order to get quantitative results.

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Determining the Appropriate Film Exposure Time
Bio-Rad Laboratories

Film has a limited linear dynamic range for light detection and is often easily saturated by the chemiluminescent signals from the blot.

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Determining the Appropriate Sample Load for Western Blots
Bio-Rad Laboratories

Reliable western blot data can be generated only when the proper sample amount of protein is used. Loading too much protein leads to signal saturation in western blots, yet too little produces weak signals.

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Avoiding Housekeeping Protein Detection Saturation
Bio-Rad Laboratories

Reliable western blot data require detection of the target and loading control proteins in the linear dynamic range. Many published western blot images show saturated protein bands, indicating that they were not measured in the linear dynamic range. Quantitative analysis based on this type of data is not reliable.

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Improved cell viability assay performance using PrestoBlue® Reagent
Tecan Trading AG

Cell proliferation and viability assays are widely used in academic and life science laboratories, and are becoming increasingly common in the pharmaceutical industry. Assessment of cellular viability markers in cell-based applications is mandatory for laboratories working with in vitro systems.

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Automation of a Homogeneous Proximity Assay for Immunogenicity Testing of Biological Drug Products
BioTek Instruments

Several challenges have surfaced during clinical evaluation of biological drug products due to a commonly associated immune response in patients. Anti-drug antibodies (ADA) are known to be frequently generated during administration of humanized monoclonal antibody therapeutics. A commonly used technology platform for assessment of immunogenicity relies on the bridging immunogenicity assay format typical of the ELISA.

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