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Featured ProductRAFT™ 3D Cell Culture System for Tissue Modeling company logo
RAFT™ 3D Cell Culture System for Tissue Modeling
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Webcasts
Rapid and Sensitive Identification of Host Cell Proteins with SWATH® LC-MS AcquisitionRapid and Sensitive Identification of Host Cell Proteins with SWATH® LC-MS Acquisition
Join Eric Johansen PhD, Senior Scientist at Stemcentrx, to learn how to dramatically increase the speed of acquisition of HCP data.
High Content Analysis using Stem Cells for Disease Modelling and Drug DiscoveryHigh Content Analysis using Stem Cells for Disease Modelling and Drug Discovery
Davide Danovi, Director, Kings College London, speaking at Stem Cells in Drug Discovery.

Market Reports
High Throughput Assay Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on high throughput flow cytometry (HT flow) screening carried out in December 2014.
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
Epigenetic Proteins & Reagents Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on epigenetic proteins and reagents carried out in March 2015.
3D Spheroid Culture Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on three dimensional (3D) spheroid culture carried out in May 2015.
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
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Scientific News
Featured Article
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.

Grant Supports Project To Develop Simple Test To Screen For Cervical Cancer
UCLA Engineering announces funding from Bill and Melinda Gates Foundation.
Injecting New Life into Old Antibiotics
A new fully synthetic way to make a class of antibiotics called macrolides from simple building blocks is set to open up a new front in the fight against antimicrobial drug resistance.
Insight into Bacterial Resilience and Antibiotic Targets
Variant of CRISPR technology paired with computerized imaging reveals essential gene networks in bacteria.
Advancing Protein Visualization
Cryo-EM methods can determine structures of small proteins bound to potential drug candidates.
Alzheimer’s Protein Serves as Natural Antibiotic
Alzheimer's-associated amyloid plaques may be part of natural process to trap microbes, findings suggest new therapeutic strategies.
Slime Mold Reveals Clues to Immune Cells’ Directional Abilities
Study from UC San Diego identifies a protein involved in the directional ability of a slime mold.
How Do You Kill A Malaria Parasite?
Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite’s skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream. The drugs also seem to trick the parasite into reproducing prematurely.
Illuminating Hidden Gene Regulators
New super-resolution technique visualizes important role of short-lived enzyme clusters.
Supressing Intenstinal Analphylaxis in Peanut Allergy
Study from National Jewish Health shows that blockade of histamine receptors suppresses intestinal anaphylaxis in peanut allergy.
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Business News
Connectivity Boost Accelerates EU-Japanese Science Collaborations
Over 50 million researchers, academics and students across Europe and Japan are set to benefit from a direct 20Gbps connectivity injection into the pan-European GÉANT network.
Vela Diagnostics Acquires Lifecode Data Interpretation Division
This acquisition puts company at the forefront in providing genomics interpretation and reporting.
Flatiron Health, FDA Collaborate
Research initiative will focus on how real-world evidence can provide new insights into the care of patients with advanced non-small cell lung cancer.
Dalton Receives Compliant Rating From Health Canada
The rating resulted from a Good Manufacturing Practices (GMP) inspection conducted at Dalton’s facility during March 2016.
NIH Funds Biobank To Support Precision Medicine Initiative Cohort Program
$142 million over five years will be awarded to the Mayo Clinic to establish the world’s largest research-cohort biobank for the PMI Cohort Program
Cigna to Cover NanoString's Prosigna® Breast Cancer Assay
NanoString Technologies has announced that Cigna has issued a positive Medical Coverage Policy decision for the Prosigna® Breast Cancer Gene Signature Assay.
QIAGEN Partners to Develop Predictive Tests in Oncology
Collaboration with Therawis addresses unmet need to guide clinical decisions in breast cancer.
Caladrius Licenses Cell Therapy Tech to AiVita
Caladrius Biosciences, Inc. has announced that it has licensed to AiVita Biomedical, Inc. (“AiVita”) the exclusive global rights to its tumor cell/dendritic cell technology for the treatment of ovarian cancer.
Horizon, Ubiquigent Enter Collaboration Agreement
Horizon’s X-MAN cell lines to be made available in conjunction with Ubiquigent’s ubiquitin-related Drug Discovery Services.
twoXAR, University of Chicago Collaborate
Collaboration aims to focus on the identification and investigation of potential new medicines for treating atherosclerosis.
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Events
8th Annual International Congr
28 May 2016
8th Annual International Congr ...
EMBO | EMBL Symposium: Microtu
29 May 2016
EMBO | EMBL Symposium: Microtu ...
2nd Bugs & Drugs: Anti-Bacteri
01 Jun 2016
2nd Bugs & Drugs: Anti-Bacteri ...
5th Antiviral Drugs Research &
01 Jun 2016
5th Antiviral Drugs Research & ...

ePosters
Phenotypic Cell-Based Screening of a High Content Imaging Cell Health Assay using the IN Cell Analyzer 2000
MRC Technology

A High Content Imaging Cell Health assay has been established in-house for phenotypic High Content Screening using the IN Cell Analyzer 2000 and Genedata Screener analysis software. We describe the assay development and initial screening of the FDA set in HepG2 cells for validation of the assay.
CRISPR-Cas9 genome editing utilizing chemically synthesized RNA
Dharmacon (part of GE Healthcare)

CRISPR-Cas9 gene editing using synthetic crRNA:tracrRNA or sgRNA is highly efficient and easy to use. Synthetic crRNA:tracrRNA is uniquely suited to in vitro and in vivo applications, in particular, DNA-free approach with Cas9 mRNA. Chemical synthesis of guide RNAs allows accurate and rapid production of arrayed crRNA libraries for high-confidence, loss-of-function screens.
Deep Phenotyping - Harnessing Data Richness for Unsupervised High-Content Analysis
Institute of high performance Computing, Astar

Recognising the key challenges, we develop an end-to-end computational framework for HCA dubbed “Deep Phenotyping” that perform unsupervised analysis to leverage on the data richness for the discovery of unknown sub-phenotypes with minimal labeling cost.
Analyzing Cell Viability in 3D Tissue Models with the ViaLight™ Plus BioAssay
1Lonza Cologne GmbH, Cologne, Germany; 2Lonza Walkersville Inc., Walkersville, MD, USA; 3Lonza Rockland Inc., Rockland, ME, USA

This poster explains how to measure cell viability easily in 3D cell cultures using the ViaLight™ Plus BioAssay.
Cell Culture and Cell Analysis using the Real Architecture for 3D Tissue (RAFT™) Culture System
1TAP Biosystems, Royston, UK;2Lonza Cologne GmbH, Cologne, Germany; 3Lonza Walkersville Inc., Walkersville, MD, USA

This poster explains how standard analysis techniques, like fluorescence microscopy, can be applied easily to RAFT™ 3D Cell Cultures.
Comparison of Normal and Asthmatic Bronchial Epithelial Cells and Smooth Muscle Cells in Monolayer and RAFT™ 3D Cell Culture System
1Lonza Walkersville Inc. Walkersville MD USA, 2Lonza Cologne GmbH, Cologne, Germany

The RAFT™ 3D cell culture system provides a valuable tool to investigate different cell types singularly or in co-cultures in an in-vivo like collagen based microenvironment.
Assessment of the Anti-angiogenic Effect of VEGFR2 siRNA in Clonetics™ HUVEC using the Lonza 4D-Nucleofector™ System
1Lonza India Pvt Ltd, Hyderabad, India; 2Lonza Cologne GmbH, Cologne, Germany; 3Lonza Walkersville, Inc., Walkersville, MD, U.S.A.

In the current study we have used siRNA targeting VEGFR2 as an example to study knockdown of VEGFR2 and subsequent inhibition of tube formation by HUVECs on Growth Factor Reduced Matrigel™ in a 96-well plate format. The same strategy can be used for screening and validating siRNA based inhibitors of the angiogenic process in vitro and thus could be of utility in anti-cancer screening strategies.
The Case for CASE: Computer-Assisted Structure Elucidation
ACD/Labs

Modern CASE systems such as Structure Elucidator Suite provide the necessary capability accurately elucidate a novel chemical structure for complex molecules based on readily available NMR data sets. This allows organizations to avoid expensive, labor-intensive, and time-consuming synthetic efforts.
A Unified Software Platform for Laboratory Informatics
Advanced Chemistry Development, Inc. (ACD/Labs), Toronto, Canada.

Reported here are capabilities in automated workflows involving analytical data with chemical structures. Specifically described is automated homogenization of data from a set of instruments, including NMR structure verification, as one solution.
Gene Expression Patterns in Donor-matched Mesenchymal Stem Cells and Osteocytes from Human Trabecular Bone
Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, UK

The study aimed to investigate gene expression profiles of osteocytes in healthy and OA bone and to compare with donor - matched MSCs.
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Application Notes
Using the µEncapsulator 1 to Capture Single Cells in Droplets with Beads
Dolomite

In order to simplify high throughput single cell methods, Dolomite has developed the µEncapsulator 1 System, a compact module that simply and securely holds a droplet generating chip, convenient sample reservoirs, and an output reservoir
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Rapid Point of use DNAble® Assay for Salmonella enterica using the Douglas Scientific® AmpliFire®
Douglas Scientific

With greater portability than real-time PCR instrumentation, the AmpliFire produces rapid and accurate results in the field or in the lab without cumbersome equipment or reagents. In a recent study, the AmpliFire® accurately detected the presence of Salmonella enterica using both purified genomic DNA and a crude sample preparation method, making it a powerful tool for point of use applications.
Rapid point of use DNAble® assay for citrus greening disease (Candidatus Liberibacter spp.) using the Douglas Scientific® AmpliFire®
Douglas Scientific

In this experiment, a crude insect preparation and a DNAble assay were used to demonstrate that the AmpliFire instrument accurately detects the presence of HLB-causing bacteria consistent with a real-time PCR system. The AmpliFire offers greater portability than real-time PCR instrumentation, and is a powerful tool for point of use applications such as management of citrus greening disease.
Multipette®/ Repeater® M4 Allows for Fast, Precise and Sterile Liquid Transfer in Cell Culture
Eppendorf AG

This application note demonstrates the huge advantages offered by Multipette M4 in terms of accuracy and precision needed for many cell culture applications.
Characterization of Protein-Protein Interactions using Triple Detection Size Exclusion Chromatography (SEC-TD)
Malvern Instruments Limited

In this application note, triple detection size exclusion chromatography (SEC-TD) is used to understand the ability of proteins to form ordered, structured complexes. The controlling mechanism behind these protein complexes is fundamental to our knowledge of protein signaling pathways and the physiological responses they control.
Microbial Detection and Quantification Using the IntelliQube® from Douglas Scientific®
Douglas Scientific

Nucleic Acid Testing (NAT) is a powerful tool for the quantification of microorganisms and are used in many fields. In this study commercially available microbial NAT kits were successfully miniaturized from 20 µL to 1.6 µL reaction volumes using the IntelliQube. The IntelliQube delivers efficient and economical high throughput sample processing for microbial qPCR applications.
Evaluation of a New Accurate, Automated and Cost-effective Approach for the Analysis of Pharmacologically Important Copy Number Variation
Douglas Scientific

The IntelliQube® from Douglas Scientific® is designed to address the need for accurate and reliable results for studies such as CNV determination.
Formation of Monodispersed Microbubbles
Dolomite

This application note describes how the Mitos P-Pump can be used in combination with the Droplet Junction Chip to produce monodispersed gas bubbles.
Gas Bubble Generation in Water using Dolomite's Small Droplet System
Dolomite

This application note describes a hydrodynamic flow-focussing based system for the monodisperse formation of nitrogen bubbles using the Small Quartz Droplet Chip based Small Droplet System.
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