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Webcasts
Microinjecting CRISPR: Options and Key Considerations for Creating Transgenic Animal ModelsMicroinjecting CRISPR: Options and Key Considerations for Creating Transgenic Animal Models
Join us to learn about experimental approaches and real-life examples for creating transgenic animal models using CRISPR.
SiLA—Standards to Improve Overall Lab EfficiencySiLA—Standards to Improve Overall Lab Efficiency
This talk covers how SiLA (Standardization in Lab Automation) makes laboratory integration simpler today and in the future.

Market Reports
High Throughput Assay Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on high throughput flow cytometry (HT flow) screening carried out in December 2014.
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
Epigenetic Proteins & Reagents Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on epigenetic proteins and reagents carried out in March 2015.
3D Spheroid Culture Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on three dimensional (3D) spheroid culture carried out in May 2015.
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
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Scientific News
Featured Article
Open Source Seed Initiative – A Welcome Boost to Global Crop Breeding
A team of plant breeders, farmers, non-profit agencies, seed advocates, and policymakers have created the Open Source Seed Initiative.

Featured Article
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.

Featured Article
Benchtop Automation Trends
Gain a better understanding of current interest in and future deployment of benchtop automated systems.

Anthrax Proteins Might Help Treat Cancerous Tumors
Studies in mice reveal novel treatment regimen.
New Cancer Drug Target Found in Dual-Function Protein
Findings from a study from TSRI have shown that targeting a protein called GlyRS might help to halt cancer growth.
Key to Chronic Fatigue Syndrome is in Your Gut, Not Head
Researchers report they have identified biological markers of the disease in gut bacteria and inflammatory microbial agents in the blood.
HIV Structure Stabilized
Findings represent ‘big accomplishment’ in biomedical engineering and design.
Four Newly-Identified Genes Could Improve Rice
A Japanese research team have applied a method used in human genetic analysis to rice and rapidly discovered four new genes that are potentially significant for agriculture. These findings could influence crop breeding and help combat food shortages caused by a growing population.
New Cancer Drug Target in Dual-Function Protein
Scientists at The Scripps Research Institute (TSRI) have identified a protein that launches cancer growth and appears to contribute to higher mortality in breast cancer patients.
Antibodies To Dengue May Alter Course Of Zika Virus Infection
Scientists at Emory Vaccine Center, in collaboration with investigators from Thailand, have found that people infected with dengue virus develop antibodies that cross-react with Zika virus.
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Business News
Inovio, GeneOne Life Science Receive Approval
Company has received approval to initiate a phase I human trial to evaluate Inovio’s Zika DNA vaccine to prevent infection from this concerning virus.
BioLineRx Announces Regulatory Submissions for Phase 2a Trial of BL-8040
The study will evaluate the safety and efficacy of the combination of BL-8040 and KEYTRUDA®, MSD’s anti-PD-1 therapy, in up to 30 subjects with metastatic pancreatic cancer.
Metabolomic Diagnostics Secures Additional $2 Million in Venture Funding
Company has secured an additional €1.6 million from investors to help complete PrePsia blood test for pre-eclampsia in first time pregnant mothers.
Monsanto, Nomad Bioscience Announce Collaboration
Monsanto and Nomad Bioscience have announced a licensing agreement whereby Monsanto has obtained rights to apply Nomad’s proprietary technology to its genome-editing projects aimed at enhancement of agricultural crops.
Agilent to Acquire iLab Solutions
Companies have announced they have signed a definitive agreement under which Agilent will acquire substantially all of the assets of iLab, the market leader in cloud-based solutions for core laboratory management.
Novartis Adds Two Bispecific Antibodies to its Development Portfolio
Agreement is the latest in a series of acquisitions and strategic collaborations that have bolstered Novartis' deep and diverse immuno-oncology pipeline.
Sartorius Acquires Cell Screening Specialist IntelliCyt
Sartorius has announced the acquisition of U.S. based IntelliCyt Corporation, an award-winning innovator and manufacturer of novel cell screening platforms used in drug discovery.
Charles River Acquires Blue Stream
Acquisition combines Blue Stream with Charles River’s existing discovery, safety assessment, and biologics capabilities creates a leading provider with the ability to support biologic and biosimilar development from characterization through clinical testing and commercialization.
Perthera Secures $8.7M Investment
Funding will accelerate goal of becoming “the first step” whenever a patient is diagnosed with cancer.
Annai Systems Provides STARPlatform to Global Consortium
The STARPlatform will enable GLASS to manage whole exome and genome sequencing data across multiple research centers.
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Events
Parasitic Infection 2016
28 Jun 2016
Parasitic Infection 2016 ...
PFS-Tech 2016
28 Jun 2016
PFS-Tech 2016 ...
Microinjecting CRISPR: Options
30 Jun 2016
Microinjecting CRISPR: Options ...
EMBL Advanced Course: Whole Tr
28 Jun 2016
EMBL Advanced Course: Whole Tr ...

ePosters
Platform Agnostic Data Processing Routine for Targeted and Untargeted Metabolite Identification in Drug Discovery
1Advanced Chemistry Development, Inc. (ACD/Labs), 8 King Street East, Toronto, ON. M5C 1B5. Canada; 2ACD/Labs, Moscow, Russia

A discussion of a new informatics solution that addresses common challenges in metabolite identification and characterization--from LC/MS data processing and metabolites prediction to reporting and databasing of assembled biotransformation knowledge.
A Novel Set of Serum-Free, Xeno-Free Differentiation Media for Adipogenesis, Osteogenesis and Chondrogenesis of Human Mesenchymal Stem Cells from Various Tissue Sources
Biological Industries

An overview of a novel SF, XF differentiation system which enables achieving defined conditions for rapid generation of differentiated hMSCs towards tissue engineering and drug screening applications.
Molecular Abnormalities in Schizophrenia: Neurotransmission, Oxidative Stress, and Apoptosis
1Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London SW7 2AZ, U.K. 2

A multi-platform approach was employed to analyse distinct brain regions implicated in schizophrenia.
Accurate Mass Spectral Database: Harnessing the Power of High Performance Mass Spectrometry at Long Last
LECO Corporation, Moscow State University

Standard mixtures comprising of alkanes, PAHs, semivolatiles, and pesticides were analyzed using a high resolution time-of-flight (HRTOF) mass spectrometer—Pegasus GC-HRT (LECO Corporation, Saint Joseph,MI)—at 10 spectra-per-second (m/z40–300) in high resolution mode (25,000 at FWHH). The resulting chromatographic peaks were automatically found, deconvoluted, and curated into an Accurate Mass Library (AML).
Super-resolution single molecule localization microscopy of the exocytotic machinery underlying insulin secretion.
Heriot-Watt Univeristy

Single molecule imaging of the tSNARE proteins involved in insulin secretion.
Automated Sample Preparation of Whole Blood for Therapeutic Drug Monitoring and Diagnostics by LC-MS using a Commercial Autosampler
1 University of Applied Sciences and Arts Northwestern Switzerland FHNW, Institute for Chemistry and Bioanalytics , Gründenstrasse 40, 4132 Muttenz; 2 CTC Analytics AG; Industriestrasse 20, CH-4222 Zw

In this poster the parameters necessary to automatically prepare whole blood samples for online LC-MS applications in the field of diagnostics and TDM have been investigated. A strategy and the most important parameters are shown for the optimization of a PAL RTC autosampler
for the preparation of whole blood samples.
Development and Application of Quantitative Immunoassays for Major Milk Allergens Bos d 5 (β-lactoglobulin) and Bos d 11 (β-casein)
1. Indoor Biotechnologies, Ltd., Cardiff, Wales, UK. 2. INRA, Gif-sur-Yvette, France

In this study, we sought to develop accurate, sensitive and reliable assays that would enable quantification of multiple milk allergens.

Diagnosing Coral disease with Metabolomic Markers
NYUAD

Application of untargeted metabolomics for the identification of disease markers in corals
Quantitative Cell-Based Bioassays for Individual and Combination Immune Checkpoint Immunotherapy Targets
Promega Corporation

Immune checkpoint receptors are promising new immunotherapy
targets for the treatment of a variety of diseases including cancer and
autoimmune-mediated disorders. We developed a suite of cell-based
bioluminescent reporter bioassays for individual and combination
immune checkpoint immunotherapy targets including: PD-1 (PD-L1 or PD-L2), CTLA-4, LAG-3, TIGIT, PD-1+TIGIT, GITR, 4-1BB, CD40, and OX40.

A Novel Set of Serum-Free, Xeno-Free Differentiation Media for Adipogenesis, Osteogenesis and Chondrogenesis of Human Mesenchymal Stem Cells from Various Tissue Sources
Biological Industries

An overview of a novel SF, XF differentiation system which enables achieving defined conditions for rapid generation of differentiated hMSCs towards tissue engineering and drug screening applications
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Application Notes
SNP Genotyping of Field Corn Samples with LGC Genomics Chemistry on the Nexar® System
Douglas Scientific

A recent study demonstrated that the Nexar® System can be successfully used to produce repeatable and easily scored SNP genotyping results with crude preps from field corn using either KASP or probe-based SNP genotyping assays in miniaturized reaction volumes. This platform also provides significant cost savings in the form of reduced PCR reaction volumes.
Genotyping of Human Reference DNA Samples with Pharmacologically Important Single Nucleotide Polymorphisms using KASP™ Genotyping Chemistry on the Nexar® System
Douglas Scientific

Five pharmacologically important SNPs were analyzed with a miniaturized PCR-based SNP genotyping method using KASP™ genotyping reagents and the Douglas Scientific® Nexar®. The Nexar along with Array Tape® significantly reduces reaction volumes, hands-on effort and over-all cost of SNP genotyping, leading to a reliable and economical alternative to traditional PCR-based SNP genotyping techniques.
Accelerating Biotherapeutic Process Development Using Differential Scanning Calorimetry
Malvern Instruments Limited

This document illustrates how the technique can be used to examine the stability of individual domains in multi-domain proteins and guide process development for antibodies and other proteins.
Protein Storage and Stability Analysis Using the Zetasizer Nano ZSP
Malvern Instruments Limited

Spidroins are large, structural proteins that make up the bulk of spider silk fibres. This application note describes the use of a Zetasizer Nano ZSP to characterize their stability at different temperatures.
Evaluating Product Texture Using Oscillatory Testing on a Rotational Rheometer
Malvern Instruments Limited

This application note shows how an amplitude sweep test can be used to provide important information relating to a materials textural properties such as stiffness, springiness, structural strength and brittleness.
Using the µEncapsulator 1 to Capture Single Cells in Droplets with Beads
Dolomite

In order to simplify high throughput single cell methods, Dolomite has developed the µEncapsulator 1 System, a compact module that simply and securely holds a droplet generating chip, convenient sample reservoirs, and an output reservoir
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Rapid Point of use DNAble® Assay for Salmonella enterica using the Douglas Scientific® AmpliFire®
Douglas Scientific

With greater portability than real-time PCR instrumentation, the AmpliFire produces rapid and accurate results in the field or in the lab without cumbersome equipment or reagents. In a recent study, the AmpliFire® accurately detected the presence of Salmonella enterica using both purified genomic DNA and a crude sample preparation method, making it a powerful tool for point of use applications.
Rapid point of use DNAble® assay for citrus greening disease (Candidatus Liberibacter spp.) using the Douglas Scientific® AmpliFire®
Douglas Scientific

In this experiment, a crude insect preparation and a DNAble assay were used to demonstrate that the AmpliFire instrument accurately detects the presence of HLB-causing bacteria consistent with a real-time PCR system. The AmpliFire offers greater portability than real-time PCR instrumentation, and is a powerful tool for point of use applications such as management of citrus greening disease.
Multipette®/ Repeater® M4 Allows for Fast, Precise and Sterile Liquid Transfer in Cell Culture
Eppendorf AG

This application note demonstrates the huge advantages offered by Multipette M4 in terms of accuracy and precision needed for many cell culture applications.
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