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Webcasts
Solutions Beyond Water - Successfully pipetting problematic liquidsSolutions Beyond Water - Successfully pipetting problematic liquids
Join us to learn how to best handle problematic liquids.
The Medicines for All Initiative: A Flow-based Synthesis of NevirapineThe Medicines for All Initiative: A Flow-based Synthesis of Nevirapine
Frank Gupton, Professor, Virginia Commonwealth University, speaking at Flow Chemistry Congress.

Market Reports
High Throughput Assay Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on high throughput flow cytometry (HT flow) screening carried out in December 2014.
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
Epigenetic Proteins & Reagents Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on epigenetic proteins and reagents carried out in March 2015.
3D Spheroid Culture Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on three dimensional (3D) spheroid culture carried out in May 2015.
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
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Scientific News
Ketamine Metabolism Lifts Depression
NIH-funded team finds rapid-acting, non-addicting agent in mouse study.
Improving Natural Killer Cancer Therapy
Vanderbilt University researchers discover transcription factor critical for NK cell expansion. Findings could lead to increased therapeutic efficacy.
Molecular Mechanism For Generating Specific Antibody Responses Discovered
Study could spur more ways to treat autoimmune disease, develop accurate vaccines.
Monovar Drills Down Into Cancer Genome
Rice, MD Anderson develop program to ID mutations in single cancer cells.
It’s Now Easier To Go With The Flow
Rice University tool simplifies comparison of flow cytometry data for laboratories.
Autism and Cancer Share a Remarkable Number of Risk Genes
Researchers with the UC Davis Comprehensive Cancer Center, MIND Institute identify more than 40 common genes.
Number Of Known Genetic Risk Factors For Endometrial Cancer Doubled
An international collaboration of researchers has identified five new gene regions that increase a woman’s risk of developing endometrial cancer, one of the most common cancers to affect women, taking the number of known gene regions associated with the disease to nine.
Genetic Variant May Help Explain Why Labradors Are Prone To Obesity
A genetic variation associated with obesity and appetite in Labrador retrievers – the UK and US’s favourite dog breed – has been identified by scientists at the University of Cambridge. The finding may explain why Labrador retrievers are more likely to become obese than dogs of other breeds.
FNIH Launches Project to Evaluate Biomarkers in Cancer Patients
Company has announced that it has launched a new project to evaluate the effectiveness of liquid biopsies as biomarkers in colorectal cancer patients.
Flowering Regulation Mechanism Discovered
Monash researchers have discovered a new mechanism that enables plants to regulate their flowering in response to raised temperatures.
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Business News
Concept Life Sciences Group Offers Unrivalled Expertise as a Strategic Partner
Company has announced that it will offer a comprehensive range of services to clients in the pharmaceutical, biotech, agrochemical, petrochemical, chemical, food, environmental and consumer industries.
Orchard Therapeutics Launched
UCL and F-Prime launch Orchard Therapeutics to treat rare childhood diseases.
Sequenom Forms In-Network Contracts
Sequenom has formed in-network contracts with Anthem Blue Cross and Blue Shield Plans for Georgia, Indiana, Kentucky, Missouri, Ohio, Virginia and Wisconsin
LabVantage Moves to iomart Hybrid Cloud
iomart has migrated LabVantage Solutions, Inc., the leading global laboratory informatics provider, to a new customised hybrid cloud platform.
Biopharmaceuticals Development & Manufacturing Project Launched
York scientists partner with industry on $1.7 M grant for drug development.
Medivation Rejects Sanofi's Unsolicited Proposal
Opportunistically-timed proposal substantially undervalues Medivation and is not in the best interests of stockholders.
Eppendorf Continues Successful Development
Group sales of €629.1 million (18.5% growth in sales).
Merck Expands Production Know-how to Deliver Full End-to-End Solution for Biopharma Industry
Company has announced that its flexible factory concept allows accelerated drug development and delivery to market and its end-to-end solution will help solve customer challenges.
Oncurious NV, BioInvent and NMTRC Initiating Phase I/IIa Study with TB-403 for the Treatment of Medulloblastoma
Company has announced that it will evaluate the safety and tolerability and explore the preliminary efficacy of TB-403 for the treatment of relapsed or refractory medulloblastoma.
TATAA Biocenter is Approved MicroRNA Profiling Service Provider by Toray
Company has announced that Toray has approved it as provider of expression profiling services on their “3D Gene” microarray platform.
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Events
ISEV Annual Meeting 2016
04 May 2016
ISEV Annual Meeting 2016 ...
Plant Genomics Congress
09 May 2016
Plant Genomics Congress ...
2nd International Conference o
09 May 2016
2nd International Conference o ...
EMBO | EMBL Symposium: New Mod
08 May 2016
EMBO | EMBL Symposium: New Mod ...

ePosters
Analyzing Cell Viability in 3D Tissue Models with the ViaLight™ Plus BioAssay
1Lonza Cologne GmbH, Cologne, Germany; 2Lonza Walkersville Inc., Walkersville, MD, USA; 3Lonza Rockland Inc., Rockland, ME, USA

This poster explains how to measure cell viability easily in 3D cell cultures using the ViaLight™ Plus BioAssay.
Cell Culture and Cell Analysis using the Real Architecture for 3D Tissue (RAFT™) Culture System
1TAP Biosystems, Royston, UK;2Lonza Cologne GmbH, Cologne, Germany; 3Lonza Walkersville Inc., Walkersville, MD, USA

This poster explains how standard analysis techniques, like fluorescence microscopy, can be applied easily to RAFT™ 3D Cell Cultures.
Comparison of Normal and Asthmatic Bronchial Epithelial Cells and Smooth Muscle Cells in Monolayer and RAFT™ 3D Cell Culture System
1Lonza Walkersville Inc. Walkersville MD USA, 2Lonza Cologne GmbH, Cologne, Germany

The RAFT™ 3D cell culture system provides a valuable tool to investigate different cell types singularly or in co-cultures in an in-vivo like collagen based microenvironment.
Assessment of the Anti-angiogenic Effect of VEGFR2 siRNA in Clonetics™ HUVEC using the Lonza 4D-Nucleofector™ System
1Lonza India Pvt Ltd, Hyderabad, India; 2Lonza Cologne GmbH, Cologne, Germany; 3Lonza Walkersville, Inc., Walkersville, MD, U.S.A.

In the current study we have used siRNA targeting VEGFR2 as an example to study knockdown of VEGFR2 and subsequent inhibition of tube formation by HUVECs on Growth Factor Reduced Matrigel™ in a 96-well plate format. The same strategy can be used for screening and validating siRNA based inhibitors of the angiogenic process in vitro and thus could be of utility in anti-cancer screening strategies.
Pharmacological Responses in Cultured Human iPSC-Derived Cortical Neurons Using Multi-Electrode Array
(1) Department of Electronics and Intelligent Systems, Tohoku Institute of Technology, Sendai, Miyagi, Japan; (2) Japan Society for the Promotion of Science, Tokyo, Japan; (3) Axol Bioscience Ltd., Ca

The functional network of human induced pluripotent stem cell (hiPSC)-derived neurons is a potentially powerful in vitro model for evaluating disease mechanisms and drug responses. However, the culture time required for the full functional maturation of individual neurons and networks is uncertain. We investigated the development of spontaneous electrophysiological activity and pharmacological responses for over 1 year in culture using multi-electrode arrays (MEAs).
Clinical Applications of “Liquid biopsy” in the Colorectal Cancer Treatmen
Saitama Medical Center, Jichi Medical University, Saitama. Japan

Liquid biopsy provides a circulating biomarker not only for treatment response but decision making of a sequential strategy.
Instrumental Investigations: A Laboratory Manual of Forensic Analytical Chemistry
Oberlin College

A laboratory manual for undergraduate analytical and forensic chemistry courses
Targeting Acute Pancreatitis by Small Molecule Inhibitors of Cyclophilin D
The University of Liverpool

Cyclophilin D (CypD) promotes opening of the mitochondrial permeability transition pore, a major contributor to acute pancreatitis. We are developing small molecule inhibitors of CypD as a possible treatment for AP and other conditions where the MPTP plays a role.
The Pathogen Box: A Catalyst for Neglected Disease Drug Discovery
Medicines for Malaria Venture, Switzerland

Modelled after the Malaria Box, the Pathogen Box contains ~400 diverse drug-like molecules active against neglected diseases of interest such as Chagas disease, cryptosporidiosis, hookworm, sleeping sickness, leishmaniasis, lymphatic filariasis, malaria, onchocerciasis, schistosomiasis, trichuriasis, tuberculosis.
Rapid electrochemical impedance spectroscopy for protein detection in Lab-on-a-Chip devices
(a) Thomas Johann Seebeck Department of Electronics, Tallinn University of Technology, Tallinn, Estonia; (b) Protobios OÜ, Tallinn, Estonia

We present results in rapid solution impedance spectroscopy to detect protein interactions (antibody-antigen) in human serum. Two different serum-antibody mixtures are measured in cuvettes, interfaced with screen-printed electrodes to determine whether the experimental setup can detect differences in composition.
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Application Notes
Rapid point of use DNAble® assay for citrus greening disease (Candidatus Liberibacter spp.) using the Douglas Scientific® AmpliFire®
Douglas Scientific

In this experiment, a crude insect preparation and a DNAble assay were used to demonstrate that the AmpliFire instrument accurately detects the presence of HLB-causing bacteria consistent with a real-time PCR system. The AmpliFire offers greater portability than real-time PCR instrumentation, and is a powerful tool for point of use applications such as management of citrus greening disease.
Multipette®/ Repeater® M4 Allows for Fast, Precise and Sterile Liquid Transfer in Cell Culture
Eppendorf AG

This application note demonstrates the huge advantages offered by Multipette M4 in terms of accuracy and precision needed for many cell culture applications.
Characterization of Protein-Protein Interactions using Triple Detection Size Exclusion Chromatography (SEC-TD)
Malvern Instruments Limited

In this application note, triple detection size exclusion chromatography (SEC-TD) is used to understand the ability of proteins to form ordered, structured complexes. The controlling mechanism behind these protein complexes is fundamental to our knowledge of protein signaling pathways and the physiological responses they control.
Microbial Detection and Quantification Using the IntelliQube® from Douglas Scientific®
Douglas Scientific

Nucleic Acid Testing (NAT) is a powerful tool for the quantification of microorganisms and are used in many fields. In this study commercially available microbial NAT kits were successfully miniaturized from 20 µL to 1.6 µL reaction volumes using the IntelliQube. The IntelliQube delivers efficient and economical high throughput sample processing for microbial qPCR applications.
Evaluation of a New Accurate, Automated and Cost-effective Approach for the Analysis of Pharmacologically Important Copy Number Variation
Douglas Scientific

The IntelliQube® from Douglas Scientific® is designed to address the need for accurate and reliable results for studies such as CNV determination.
Formation of Monodispersed Microbubbles
Dolomite

This application note describes how the Mitos P-Pump can be used in combination with the Droplet Junction Chip to produce monodispersed gas bubbles.
Gas Bubble Generation in Water using Dolomite's Small Droplet System
Dolomite

This application note describes a hydrodynamic flow-focussing based system for the monodisperse formation of nitrogen bubbles using the Small Quartz Droplet Chip based Small Droplet System.
Quantifying µ-Scale Mixing Time of Sodium Hydroxide and Phenolphthalein Using Dolomite's Micromixer System
Dolomite

This application note evaluates mixing using a rapid chemical reaction causing a colour change as the indicator of mixing.
Introduction to Mixing and Droplet Production in Microfluidics using Dolomite's Educational Microfluidic System
Dolomite

This application note introduces researchers to fundamental fluid operations in microfluidics using Dolomite's Educational Microfluidic System.
Characterisation of Droplet Junction Chip with Hexadecane and Water
Dolomite

This application note describes how Dolomite's Droplet Junction Chip can be used to generate water droplets in a hexadecane oil carrier stream. By controlling the pressure of the oil and water input reservoir, different flow regimes and droplet sizes were observed.
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