Developmental Protein Plays Role in Spread of Cancer
A protein used by embryo cells during early development, and recently found in many different types of cancer, apparently serves as a switch regulating metastasis.

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Scientists Coax Brain to Regenerate Cells Lost in Huntington’s Disease
The study appears in the journal Cell Stem Cell.

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Major Funding for Dairy Cow Research
Researchers have received a major funding award to develop a project that could ultimately lead to an early warning system for poor health and welfare in dairy cattle.

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Rothamsted Research Plants Autumn-sown Wheat as Part of its GM Field Trial
The extension of the current trial will allow scientists to also study the effects of autumn aphid infestations on their experimental 'aphid repelling' wheat.

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Plankton Genome Sheds Light into Making Fish Oils
Rothamsted Research scientists have sequenced the whole genome and started characterizing the genes of the ecologically important marine alga Ehux.

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Bringing Out the Usual – and Unusual – Cancer Genomics Suspects
Several years ago, researchers sequencing lung cancer genomes encountered a number of red herrings.

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Experimental Vaccine Shows Promise against TB Meningitis
Study in animals lays groundwork for new prevention strategies in brain TB.

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Yale Researchers Unravel Genetics of Dyslexia and Language Impairment
A new study of the genetic origins of dyslexia and other learning disabilities could allow for earlier diagnoses and more successful interventions.

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Circuitry of Cells Involved in Immunity, Autoimmune Diseases Exposed
Connections point to interplay between salt and genetic factors.

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Genetically Modified Stem Cells are Effective Against Acute Respiratory Diseases
Administration of genetically modified mesenchymal stem cells regenerates lung tissue and stops the inflammatory process in mice with acute lung injury.

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Successful Scale-Up in the Production of CodeXol® Detergent Alcohols
Codexis and Chemtex achieve key milestone in commercial development of bio-based chemicals from non-food cellulosic biomass.

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UroSens Receives Funding and Enters into Clinical Trials
Board of directors strengthened with key appointments.

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AMRI Promotes Susan Collins to Director, Business Development
Ms. Collins is responsible for leading AMRI’s North American Discovery Business Development team.

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ChemAxon Provides Chemistry Informatics Platform for the European Lead Factory
ChemAxon will provide the core tools to support the pan European initiative.

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Horizon Establishes Two New Centers of Excellence in Cambridge, UK
Leading researchers Steve Jackson and David Rubinsztein to apply rAAV gene editing technology in studies of oncology and neurodegenerative disease.

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Horizon Discovery and Hisun Pharmaceuticals Partner on Bioproduction Cell Line
Precisely engineered CHO cell line will enable faster, more efficient development in production of therapeutic antibodies.

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Lab Innovations 2013 Programme of Talks Includes New Test for Horsemeat DNA
New safe DNA electrophoresis to be shared at Lab Innovations on 6 & 7 November 2013.

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Almac Announces Further Expansion and 229 New Jobs
Dual expansion with completion of a new non-GMP drug development facility.

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New Book Chapter from CEM on Microwave Peptide Synthesis
Contribution of new chapter appears in Microwaves in Organic Synthesis, Volume 2.

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Proteome Sciences to Develop Cancer Pathway Profiling Assays
New MS3 TMT® mass spectrometry technique to determine relative quantitation of proteins in multiple samples simultaneously.

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Function of Protein Kinase C-1 in memory in Caenorhabditis elegans
Routtenberg Labs

To study long lasting olfactory memory in C. elegans, we conditioned the nematodes to form an association between the odorant benzaldehyde and starvation.

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Microfluidic Sample Extraction Device with an Integrated Pressure Measurement
IMTEK, University of Freiburg

Bioanalytical applications, like the monitoring of metabolic processes, often require a continuous sample extraction. In this work we describe a microfluidic device which is able to subsequently extract samples in microliter range out of a continuous sample stream and provides an optional integrated channel for the measurement of the fluid pressure.

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Concentration and Mixing Effects on the Production of Amine Hydrochloride Salts in a Confined Impinging Jet Reactor
University of Alberta

Results show that different AHC salts can be formed under different process conditions.

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Cytosolic Delivery of Anticancer Drug Using Endosomolytic Peptide Bearing Nanoparticles Against Solid Tumor
Dr. Hari Singh Gour University, Sagar

The objective of the present project is to develop transferrin coupled biodegradable nanoparticles (NPs) with high encapsulation efficiency (Doxorubicin). GALA (Glutamic acid-alanine-leucine alanine) a pH sensitive fusogenic endosomolytic peptide is added to the formulation to enhance the endosomal lysis that will further potentiate the delivery of anticancer drug inside tumor cell as well as prevent loss of drug via endosomes.

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Highly Efficient Activated Carbon From Palm Shell as an Adsorbent of Toxin/Poison
International Islamic University Malaysia

Highly efficient activated carbon as an adsorbent of toxins has been successfully produced from palm shell through chemical activation process using phosphoric acid as activating agents.

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Oral Health Management of a Patient with 47 XYY Syndrome
College of Dentistry, Salman bin Abdulaziz University

The 47XYY syndrome is an aneuploidy of sex chromosomes, where a human male receives an extra Y-chromosome making a total of 47 instead of the usual 46.

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The Challenges of Relieving Cancer Pain: A Literature Review
NHS

This study aims to explore the discrepancy between the increasing array of treatments for cancer pain, as well as the evidence that it can be managed effectively in the majority of cases, and its persisting prevalence.

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Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies
ReachBio LLC

This study aimed to assess if the CFC assay could also be useful at predicting the increased toxicity of drug combinations relative to the toxicity caused by the relevant single agent.

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Predictive in silico Screening to Determine Vector-Mediated Transport Properties for the Blood-Brain Barrier Choline Transporter
University of Wurzburg

An attempt to analyze vector-mediated transport properties for the blood-brain barrier choline transporter (BBBCHT) was made to assess and improve drug delivery to the central nervous system.

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Comparison of Dissociated Phoria Measuring Methods. Repeatability and Reliability
CBO

The aim of this study is to determine the reliability and compare reproducibility of different dissociated phoria measure tests.

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Validating the Expression Consistency of a Housekeeping Protein
Bio-Rad Laboratories

Housekeeping proteins (HKP) are typically used as loading controls because it is assumed that the HKP expression level remains consistent across samples. However, there is evidence that HKP expression levels change in many scenarios, including siRNA treatment, cell death, cell differentiation, etc.

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A Method for Greater Reliability in Western Blot Loading Controls: Stain-Free Total Protein Quantitation
Bio-Rad Laboratories

Reliable assessment of changes in target protein levels by western blot requires measurement of both the target and loading control proteins in the linear dynamic range. Stain-free technology is a novel method introduced by Bio-Rad to visualize and quantify proteins in gels and blots.

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General V3 Western Blotting Protocol
Bio-Rad Laboratories

Western blotting is a very useful and widely adopted lab technique, but the traditional procedure can be long and tedious. Researchers can assess only whether a blot image is captured at the end of the long procedure and the quality of western blot data is sometimes challenged due to poor loading controls.

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Determining the Appropriate Sample Load When Using a Stain-Free V3 Western Workflow™
Bio-Rad Laboratories

Traditional western blot workflows require an appropriate sample load to detect both target proteins and loading control proteins. The discrepancy between these quantities often leads to oversaturated protein bands, forcing researchers to sometimes run two duplicate gels or titrate down the antibody concentration in order to get quantitative results.

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Determining the Appropriate Film Exposure Time
Bio-Rad Laboratories

Film has a limited linear dynamic range for light detection and is often easily saturated by the chemiluminescent signals from the blot.

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Determining the Appropriate Sample Load for Western Blots
Bio-Rad Laboratories

Reliable western blot data can be generated only when the proper sample amount of protein is used. Loading too much protein leads to signal saturation in western blots, yet too little produces weak signals.

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Avoiding Housekeeping Protein Detection Saturation
Bio-Rad Laboratories

Reliable western blot data require detection of the target and loading control proteins in the linear dynamic range. Many published western blot images show saturated protein bands, indicating that they were not measured in the linear dynamic range. Quantitative analysis based on this type of data is not reliable.

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Improved cell viability assay performance using PrestoBlue® Reagent
Tecan Trading AG

Cell proliferation and viability assays are widely used in academic and life science laboratories, and are becoming increasingly common in the pharmaceutical industry. Assessment of cellular viability markers in cell-based applications is mandatory for laboratories working with in vitro systems.

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Automation of a Homogeneous Proximity Assay for Immunogenicity Testing of Biological Drug Products
BioTek Instruments

Several challenges have surfaced during clinical evaluation of biological drug products due to a commonly associated immune response in patients. Anti-drug antibodies (ADA) are known to be frequently generated during administration of humanized monoclonal antibody therapeutics. A commonly used technology platform for assessment of immunogenicity relies on the bridging immunogenicity assay format typical of the ELISA.

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Molecular indexing for improved RNA-Seq analysis
Bioo Scientific

Most modern methods for nucleic acid analysis require the use of enzyme processing, such as DNA polymerase reactions, in the sample preparation or measurement steps. Although necessary, these enzymatic steps introduce errors in the form of incorrect sequence and misrepresented copy number. NEXTflex™ qRNA-Seq™ Kit from Bioo Scientific adds no additional steps to the work flow, costs no more than a conventional library preparation kit and increases the precision of downstream analysis.

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