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Webcasts
The First Discovery of a Single Digit Nanomolar Small Molecule Blocker of a Protein-protein Interaction TargetThe First Discovery of a Single Digit Nanomolar Small Molecule Blocker of a Protein-protein Interaction Target
Nils Hansen, Vipergen ApS, speaking at Discovery Chemistry Congress 2015.
Handling Slower Reactions in Flow Handling Slower Reactions in Flow
Robert Ashe, AM Technology, speaking at Flow Chemistry India 2015.

Market Reports
High Throughput Assay Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on high throughput flow cytometry (HT flow) screening carried out in December 2014.
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
Epigenetic Proteins & Reagents Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on epigenetic proteins and reagents carried out in March 2015.
3D Spheroid Culture Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on three dimensional (3D) spheroid culture carried out in May 2015.
Critical Care Therapeutics in Major Developed Markets to 2020
GBI Research

The report provides in-depth analysis of the critical care market in the US, UK, France, Germany, Italy, Spain, Japan and Canada with an estimation of market size for 2013, along with market forecasts to 2020.
Apheresis Market, Applications, Devices & Disposables - Forecasts to 2017
MarketsandMarkets

The research report categorizes this market into procedure, application, technology, product type and end-user. All these markets are broken down into segments and sub-segments, providing exhaustive value analysis for 2010, 2011 and 2012, as well as forecast up to 2017.
Inherited Orphan Blood Disorders Therapeutics Market to 2019
GBI Research

The report provides insights into the up-and-coming trends of a portion of the inherited orphan blood disorder pharmaceutical market by examining sickle cell anemia, thalassemia and Hereditary Angioedema (HAE) in seven major markets.
Global Molecular Cytogenetics Market 2014-2018
Technavio

This report covers the present scenario and the growth prospects of the Global Molecular Cytogenetics market for the period 2014-2018.
Tissue Diagnostics Market by Technology, Disease, Product, End-Users & Region - Trends & Forecast to 2018
MarketsandMarkets

The report provides qualitative insights about key market shares, growth rates, and market drivers for all important sub-segments. It maps the market sizes and growth rates of each sub-segment and identifies the segments poised for rapid growth in each of the 20 geographic and regional segments.
Digital Pathology Market by Slide Scanners, Analytics, Delivery Modes & by Whole Slide Image Storage - Global Forecasts & Trends to 2018
MarketsandMarkets

The global digital pathology market was valued at an estimated $250.2 million in 2013 and is expected to grow at a CAGR of 11.8%, to reach an estimated $437 million by 2018.
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Scientific News
Personalized Screening for Ovarian Cancer
With 60% of women diagnosed with ovarian cancer dying within five years of diagnosis there has been considerable efforts to try to detect the disease at an earlier stage.
Advancing Cancer Drug Design with Image of Key Protein
Scientists have pioneered the use of a high-powered imaging technique to picture in exquisite detail one of the central proteins of life – a cellular recycling unit with a role in many diseases.
Mould Unlocks New Route to Biofuels
Scientists at The University of Manchester have made an important discovery that forms the basis for the development of new applications in biofuels and the sustainable manufacturing of chemicals.
'Invisible' Protein Structure Explains the Power of Enzymes
A research group at Umeå University in Sweden has managed to capture and describe a protein structure that, until now, has been impossible to study.
Unraveling the Elusive Structure of HIV Protein
Snapshots of HIV virus’ proteins may help design new ways to fight the disease.
Visualizing RNAi at Work
Researchers have revealed the molecular mechanism of RNA interference by real time observation of target RNA cleavage at the single-molecule level.
Colitis in Infants Caused by Their Own Intestinal Flora?
Researchers uncover links between an imbalanced gut flora and Colitis in infants.
His and Hers Pain Circuitry in the Spinal Cord
New animal research reveals fundamental sex differences in how pain is processed.
Microfluidic Device Mixes And Matches DNA For Synthetic Biology
Researchers have developed a microfluidic device that quickly builds packages of DNA and delivers them into bacteria or yeast for further testing.
Gene Therapy for Cystic Fibrosis Shows Encouraging Trial Results
A therapy that replaces the faulty gene responsible for cystic fibrosis in patients' lungs has produced encouraging results in a major UK trial.
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Business News
Congenica's Andrea Haworth Selected as NHS Innovation Accelerator Fellow
Andrea Haworth, Head of Clinical Services at Congenica, has been selected as one of 17 new fellows by the recently established NHS Innovation Accelerator (NIA) to assist with the faster and more effective adoption of proven innovations within the NHS.
Audience Inspired at Laser and Accelerator Showcase
Students and researchers at Cockcroft Institute event inspired by talks from renowned scientists including Prof. Carsten P. Welsch, Prof. Victor Malka and Prof. Brian Cox.
Quest, Quintiles Launch Joint Venture
The companies have announced that they have launched their previously announced joint venture, a clinical trials lab business dubbed Q2 Solutions.
Sartorius Acquires Cellca
Sartorius Stedim Biotech (SSB) acquired Cellca, a Laupheim, Germany-based company that specializes in cell line and process development.
Crown Bioscience Strengthens Pre-Clinical Leadership Team with Senior Appointment
The company has appointed Laurie Heilmann as senior vice president.
Crown Bioscience Announces First European Symposium on Translational Oncology
Key opinion leaders to discuss the use of translational platforms in accelerating oncology drug discovery and the evaluation of novel treatment candidates into the clinic.
MEDIAN Announces a Private Placement of €19.8 Million at a €12 Share Price
This financing will allow MEDIAN Technologies to accelerate implementation of its global growth plans and further enhance customer offerings.
Crown Appoint New Business Development Manager
The drug discovery company welcomes Sebastian Dempe as Business Development Manager for central Europe.
Crown Bioscience Expands its Partnership with The National Resource Center for Mutant Mice
The expanded collaboration will focus on developing immuno-oncology mouse models and other disease-specific experimental models supporting translational medical research.
Arrowhead Begins Trial of ARC-AAT
The company has announced that it has dosed the first patient in Part B of a Phase 1 clinical trial of ARC-AAT.
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Events
Parallel Trade – Management St
07 Jul 2015
Parallel Trade – Management St ...
IP and the Generics Industry
08 Jul 2015
IP and the Generics Industry ...
Developing and Commercialising
08 Jul 2015
Developing and Commercialising ...
Testing Medicines With Childre
08 Jul 2015
Testing Medicines With Childre ...

ePosters
Tools for studying and using small RNAs: from pathways to functions to therapies
Cold Spring Harbor Laboratory, Watson School of Biological Sciences

This poster provides an overview of the tools that have been developed to understand the functions of small RNAs and, conversely, the use of small RNAs as tools. Tools that are based on small RNAs have been exploited to investigate gene function in cultured cells and in living animals. Small RNA biogenesis, discovery and functional roles are explored in detail. Screening approaches to functional genomics, in vivo methods and potential therapeutic applications are discussed.
An HTS-Compatible Plate For Highly Miniaturized Cultures Of Primary Human Bronchial Epithelial Cells At Air-Liquid Interface
1BellBrook Labs, Madison, WI, USA 2UAB Cystic Fibrosis Research Center, Birmingham, AL, USA

Primary human bronchial epithelial cells (HBE) cultured at air liquid interface (ALI) exhibit striking similarity to the in vivo situation, including both tissue architecture and ion channel functionality. Cultures of this type serve as a gold standard for predicting therapeutic activity in airway diseases such as cystic fibrosis.
Increasing gene editing efficiencies in eukaryotic cell lines by selection of appropriate CRISPR-Cas9 reagents
GE Healthcare Dharmacon, Inc.

Overview of various CRISPR-Cas9 reagents to provide the highest efficiency of gene editing in your experiments.
Knockdown of p53 by Accell self-delivering siRNA causes inhibition of p53-dependent DNA damage response in IMR-32 neuroblastoma cell line and β-amyloid toxicity in rat cortical neurons
GE Healthcare Dharmacon, Inc.

Here we describe how application of Accell siRNA enabled the development of a high content screening assay in IMR-32 neuroblastoma cells and a whole culture cell viability assay in primary rat cortical neurons.
An Efficient Method for the Incorporation of Molecular Probes at Multiple/Specific sites in RNA: Levulinyl Protection for 2'-ACE ® , 5'-Silyl Oligoribonucleotide Synthesis
GE Healthcare Dharmacon, Inc.

A unique method that uses a levulinate ester as a protecting group to introduce conjugates or molecular probes to virtually any location in a synthetic RNA molecule is discussed. The Levulinyl protecting group is stable in RNA synthesis conditions and can be removed without affecting the other parts of the synthesized RNA. We show the capabilities of this approach with three high-complexity synthesis examples.
Acoustophoretic microfluidic device for high throughput DNA sequencing
Dept. of Biomedical Engineering IIT Hyderabad

Multiphysics modelling for acoustic standing wave technology combined with micro-technology which can be used for manipulation and concentration on typical Lab-on-Chip devices for DNA sequencing.
Development of a Paper-Based Fluidic Device for Phosphorus Detection
Saginaw Valley State University (SVSU)

This poster displays the successful beginning stages of an innovative way to detect phosphorus in standing bodies of water by minimizing the quantity of chemicals used, reducing the cost of analysis instrumentation, allowing the potential for real-time monitoring, and producing consistent and reliable results.
Assessment of the efficiency of encapsulation of a fluorescent drug using Nanoparticle Tracking Analysis
Malvern Instruments Ltd

This poster outlines an example where the methodology of Nanoparticle Tracking Analysis (NTA) is used to characterise nanoparticles for drug delivery purposes.
Single Cell Whole Genome Amplification
GE Global Research

The analysis of genomes at the single cell level offers unprecedented biological insights in diverse fields such as cancer research, immunology & microbiology. This poster discusses the a technology for amplification of genomic DNA form a single cell, that provides utmost sensitivity, accuracy & robustness. GE Healthcare Life Sciences had previously developed method of multiple strand displacement amplification (MDA) by Phi29 DNA polymerase
The Prestwick Chemical Library (R), A Valuable Tool for Screening
1. Prestwick Chemical, 220 Blvd Gonthier d'Andernach, 67400 Strasbourg-Illkirch, FRANCE 2. University of Strasbourg, Therapeuthic Innovation Laboratory, UMR7200 CNRS, Faculty of Pharmacy, 74 route du

The Prestwick Chemical Library® (PCL) is Prestwick’s flagship product dedicated to screening. It is a collection of 1280 molecules comprising 100% approved drugs (FDA, EMEA and other agencies) selected for their high chemical and pharmacological diversity. The PCL was designed to reduce the risk of "low quality" hits and therefore the cost of the initial screening, and appears to be an efficient smart library for hit discovery. The PCL comes with an extended fully-annotated database.
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Application Notes
Determination of Pressure Sensitive Tack and Adhesion Using Axial Measurements on a Rotational Rheometer
EKF Diagnostics

This application note relates to a test which is commonly used in the adhesives industry, known as the inverted probe test. In this test an inverted probe is brought in to contact with the adhesive at a fixed speed, contact pressure and contact time. The tack is then recorded as the maximum force required to break the resultant bond.
Assessing Tackiness and Adhesion Using a Pull Away Test on a Rotational Rheometer
Malvern Instruments Limited

This application note relates to a test which is commonly used in the adhesives industry, known as the inverted probe test. In this test an inverted probe is brought in to contact with the adhesive at a fixed speed, contact pressure and contact time. The tack is then recorded as the maximum force required to break the resultant bond.
Quantifying Shear Thickening Behaviour Using the Power Law Model on a Rotational Rheometer
Malvern Instruments Limited

This note discusses an experiment run on the shear thickening behavior of a 75% w/w corn starch/water suspension mixture which was evaluated by performing a table of shear rate test and analyzing the resultant curve by fitting a power law model.
NanoSight NTA Concentration Measurement Upgrade
Malvern Instruments Limited

This note discusses how the NTA concentration measurement has been modified to provide improved accuracy,precision and reproducibility of concentration measurements on a range of nanoparticle types, covering a broad size and concentration range.
Determining the Fluorescence Limit of Detection for a Given Flourophore
Malvern Instruments Limited

This note works through an experiment to approximately establish a baseline in terms of the fluorescence limit of detection for a given fluorophore.
The Investigative Power of Multiple Detectors: a Case Study of a Semi-Pure ß-Amylase Extract
Malvern Instruments Limited

This note discusses the analysis of a semi-purified protein mixture containing ß-amylase. Step-by-step, we show how different properties of the proteins elicit a specific response in each detector and how the coupling this data can be qualitatively and quantitatively evaluated.
Utilization of kinITC in AFFINImeter
Malvern Instruments Limited

This note discusses how and when can kinetic information be retrieved from ITC power curves.
Assessing Product Stability During Transportation Using A Rotational Rheometer
Malvern Instruments Limited

This note discusses a simple rheological test for assessing product stability during transportation.
Dependance of Viscosity and Foam Consistency on Gas Volume Fraction
Malvern Instruments Limited

This note describes an empirical method for correlating foam rheology with gas volume fraction.
Predicting the Compounding Performance of Pressure Sensitive Adhesives (PSA’s)
Malvern Instruments Limited

This note discusses a method for assessing pump-ability and mix-ability of Pressure Sensitive Adhesives during manufacture.
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