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Featured Products
Featured ProductReduce water consumption & risk of flooding in your laboratory with the NEW CondenSyn air condenser company logo
Reduce water consumption & risk of flooding in your laboratory with the NEW CondenSyn air condenser
Featured ProductThe New Reference HTS Microplate Reader from BMG LABTECH company logo
The New Reference HTS Microplate Reader from BMG LABTECH

Webcasts
Lab-on-Chip Platform Technologies for Point-of-Care Testing and Cell CulturingLab-on-Chip Platform Technologies for Point-of-Care Testing and Cell Culturing
This presentation focuses on recent advances in platform technologies developed at Micronit for applications within point-of-care diagnostics and cell culturing. A few examples developed within research projects are presented to illustrate the applicability of the developed technologies.
The Bru-seq Technology Platform for Nascent RNA analysisThe Bru-seq Technology Platform for Nascent RNA analysis
Mats Ljungman, Professor, University of Michigan will present a set of novel techniques to analyze many aspects of gene expression based on the capturing of nascent RNA.

Market Reports
High Throughput Assay Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on high throughput flow cytometry (HT flow) screening carried out in December 2014.
Mobile Technology In The Lab Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on the use of mobile technology to monitor and control of lab instruments and automated systems carried out in April 2015.
Epigenetic Proteins & Reagents Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on epigenetic proteins and reagents carried out in March 2015.
3D Spheroid Culture Trends 2015
HTStec Limited

This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on three dimensional (3D) spheroid culture carried out in May 2015.
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Cell-Based Label-Free Detection Trends 2014
HTStec Limited

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on cell-based label-free (LF) detection carried out in July and August 2014. The study also examined in detail the current market landscape, application areas and interest in purchasing new products/systems.
HTS Metrics & Future Direction Trends 2014
HTStec

This market report summarizes the results of HTStec’s global web-based benchmarking survey on high throughput screening (HTS) metrics and future directions carried out in July 2014. The survey was initiated by HTStec as part of its tracking of life science marketplaces and to update our previous report (April 2012). It followed an approach from Pharma to benchmark recent HTS metrics.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Epigenetic Modification Screening Trends 2014
HTStec

This market report summarizes the results of HTStec’s 3nd industry-wide global web-based benchmarking survey on epigenetic modification screening carried out in May 2014.
Multi-Channel Pipettor QC Trends 2014
HTStec

Multi-channel pipettors are essential tools in most life science laboratories today. Yet the impact of undertaking quality control (QC) measures on improving data quality, enhancing productivity/efficiency and reducing experimental failures has only relatively recently been recognized. Understanding how lab users approach the issue of pipettor QC is important as the industry struggles to adopt standards for automated pipetting.
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Scientific News
Head Injury Patients have Protein Clumps Associated with Alzheimer’s Disease
Scientists have revealed that protein clumps associated with Alzheimer's disease are also found in the brains of people who have had a head injury.
Exposure to Air Pollution 30 Years Ago Associated with Increased Risk of Death
Exposure to air pollution more than 30 years ago may still affect an individual's mortality risk today, according to new research from Imperial College London.
More Then 1 in 20 U.S. Children have Dizziness and Balance Problems
Researchers at NIH have found that girls have a higher prevalence of dizziness and balance problems compared to boys, 5.7 percent and 5.0 percent.
Biosensors on Demand
New strategy results in custom "designer proteins" for sensing a variety of molecules.
Low-Cost, Portable NQR Spectroscopy
A researcher at Case Western Reserve University is developing a low-cost, portable prototype designed to detect tainted medicines and food supplements that otherwise can make their way to consumers. The technology can authenticate good medicines and supplements.
Structure of Brain Plaques in Huntington's
Researchers at the University of Pittsburgh School of Medicine have shown that the core of the protein clumps found in the brains of people with Huntington's disease have a distinctive structure, a finding that could shed light on the molecular mechanisms underlying the neurodegenerative disorder.
Insights into the Function of the Main Class of Drug Targets
About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors.
Spero Therapeutics Announces $30 Million Series B Preferred Financing
Company has announced financing of $30 million to support development of novel therapies to treat gram-negative bacterial infections.
Unique Mechanism for a High-Risk Leukemia
Researchers uncovered the aberrant mechanism underlying a notoriously treatment-resistant acute lymphoblastic leukemia subtype; findings offer lessons for understanding all cancers.
Visualizing a Cancer Drug Target at Atomic Resolution
Using cryo-electron microscopy, researchers were able to view, in atomic detail, the binding of a potential small molecule drug to a key protein in cancer cells.
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Business News
Featured Article
Multi-Mode Microplate Reader Trends
In this article we explore end-user opinion of some the new features available on MM plate readers and their potential influence on purchasing decision for a new MM plate reader.

Transgene and ABL Announce the Acquisition
Company has announced the acquisition of its production asset in Illkirch by ABL Europe.
Rigaku Announces the NANOPIX, its Latest Small Angle and Wide Angle X-ray Scattering (SAXS/WAXS) Measurement System
Company has announced the Nanopix measurement system for both small angle scattering (SAXS) and wide angle scattering (WAXS) measurements, which makes it possible to evaluate multiscale structures from sub-nanometer to nano-order (0.1 nm to 100 nm).
With $3M Award, HSU Generates Stem Cell Scholars
Humboldt State’s cutting-edge program to prepare the next generation of stem cell and regenerative medicine professionals has received a major boost.
VBI, GSK Collaborate
VBI Vaccines has entered into a research collaboration with GlaxoSmithKline Biologicals SA (“GSK”) to evaluate VBI’s LPV™ Platform. VBI’s LPV Platform is a proprietary formulation and process that enables the development of vaccines and biologics with improved stability and preserved potency.
A Quantitative View of Flexible Electronics
The latest Olympus application note details how observing in situ mechanical testing of flexible electronic devices with the Olympus LEXT OLS4100 confocal laser scanning microscope is providing valuable quantitative information for optimising interconnect design.
Quotient Clinical Celebrates its 100th RapidFACT® Program
Quotient Clinical, the Translational Pharmaceutics® company, has announced that it has completed its 100th RapidFACT (Rapid Formulation development And Clinical Testing) program – a significant milestone in the growth of this service, which addresses drug R&D productivity issues.
Inside Raman 2016 is to be held at the Renishaw Innovation Centre
Renishaw's Raman spectroscopy team will be hosting its next Inside Raman UK event on 19th April 2016. It will be held, for the very first time, at Renishaw's New Mills headquarters in Gloucestershire.
Magritek Benchtop Spinsolve Used to Teach Students How to Apply NMR for Spectroscopic Characterization
Magritek report on the use of their Spinsolve Benchtop NMR spectrometer in the practical teaching of organic chemistry students at Tarrant County College in Fort Worth, Texas.
BAP Pharma Opens US Headquarters
The company has announced the opening of its new US headquarters in Landing, New Jersey for clinical trial services.
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Events
IoT Tech Expo Europe
10 Feb 2016
IoT Tech Expo Europe ...
World Generic Medicines Congre
10 Feb 2016
World Generic Medicines Congre ...
Biosimilar Drug Development Wo
10 Feb 2016
Biosimilar Drug Development Wo ...
Human Microbiome Congress 2016
10 Feb 2016
Human Microbiome Congress 2016 ...

ePosters
Design considerations for highly specific and efficient synthetic crRNA molecules
GE Healthcare Dharmacon, Inc.

An overview of our rational design algorithm for picking highly functional crRNA sequences in combination with comprehensive specificity analysis.
A New Dual Luciferase Assay Using NanoLuc® Enables a Second Generation Coincidence Reporter System to Reduce False Hits in HTS Poster
Promega Corporation

Luciferase-based reporter-gene assays remain a cornerstone of high-throughput screening of compounds because of their high sensitivity and dynamic range. However, a substantial number of non-relevant hits can be generated due to direct interaction of compounds with the luciferase reporter.
A Novel Bioluminescent HTS Method for Rapid NAD(P)/NAD(P)H Detection Poster
Promega Corporation

Nicotinamide adenine dinucleotides (NAD+, NADH, NADP+ and NADPH) are fundamental co-factors of cellular energy metabolism. These dinucleotides are essential for macromolecule biosynthesis and the maintenance of the cellular redox potential. Our new rapid, easy-to-use assays for measuring dinucleotides are convenient tool for investigating their role in these processes.
A Simple Plate Based Assay Using pH Sensor Dye to Screen for Internalizing Antibody
Promega Corporation

Receptor mediated internalization is a key mechanism of action (MOA) for antibody drug conjugates (ADCs). However, current methods of studying antibody internalization have several limitations including: 1) A multistep process not suitable for screening; 2) Low signal-to-background ratios; 3) Not suitable for kinetic measurements. We have developed a method that mitigates problems associated with traditional internalization assays.
An IgG Cleaving Protease from S equi with Improved Activity Against Mouse IgGs
Promega Corporation

Here we have expressed and purified a modified recombinant IdeZ, and show that it has significantly improved activity against mouse IgG2a and IgG3 subclasses when compared to IdeS. We also demonstrate the use of IdeZ in LC-MS workflows for human and mouse IgG characterization.
Better Cell-Based Assays for Anti-CTLA-4, Anti-PD-1/PD-L1, and Bispecific Immunotherapy Drug Studies
Promega Corporation

Here we report the development of a panel of robust reporter assays to measure the potencies for biologics in immunotherapy. These assays reflect mode of action and can serve as valuable tools in immunotherapy drug development and discovery.
CellTiter-Glo® 2.0: A Novel Luminescent Cell Viability Assay with Greatly Enhanced Storage Stability
Promega Corporation

Here we report on the attributes of a novel ATP detection reagent for cell viability with all of the assay performance of the previous CellTiter-Glo® Reagent, but now with markedly enhanced stability as a single component in a liquid format. These new features provide for much greater ease-of-use in that storage of the reagent at 4°C eliminates the requirement for reagent thawing and minimizes temperature equilibration time.
Design and Validation of Bioluminescent Assays for 3D Cell Culture Models Poster
Promega Corporation

Cells cultured in 3D model systems often acquire relatively large in vivo-like structures compared to the thickness of a 2D monolayer of cells grown on standard plastic plates.
Development of a Robust Reporter-based T cell Activation Assay for Therapeutic Biologics in Immunotherapy
Promega Corporation

Jurkat T-cells stably expressing luciferase reporter driven by IL2 promoter or NFAT-RE, are used as effector cells. Tumor cell lines endogenously expressing cancer antigen are used as antigen presenting cells (APC). By co-cultivating the two cell lines in the presence of CD3 bispecific antibody, TCR/CD3 is activated in Jurkat effector cells. Luciferase activity is up regulated through IL-2 promoter or NFAT-RE activation.
iPSC-Derived Cardiomyocytes and Luciferase Reporters: A Robust Reporting Platform for Monitoring Cardioprotection and Pathway Biology in Endogenous Human Tissue Cells
Promega Corporation

Pathophysiological conditions, medical interventions, and off-target toxicities can all result in cellular oxidative stress. In cardiac myocytes, prolonged and/or excessive oxidative stress can lead to cardiotoxicity: a primary cause of developmental delays, black-box warnings, and post-launch withdrawal of pharmaceuticals.
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Application Notes
Muliplex SNP Genotyping of Field Corn Crude Samples with Probe-Based Assays using the IntelliQube® from Douglas Scientific®
Douglas Scientific

This study evaluated multiplex genotyping on the IntelliQube, a PCR instrument optimized for 1.6 µL reaction volumes in Array Tape®. It demonstrates the feasibility of achieving two SNP genotyping results in a single reaction well. IntelliQube provides cost savings through miniaturized PCR reaction volumes, shorter thermal cycling times, and multiplex reactions without compromising data quality.
Rapid point of use Grouper Chek™ assay using the Douglas Scientific® AmpliFire® detects seafood fraud
Douglas Scientific

The AmpliFire by Douglas Scientific along with GrouperChek isothermal amplification chemistry from PureMolecular, LLC provide a simple and portable tool to perform genetic analysis at the point of use. This paper demonstrates the ability of the AmpliFire combined with the GrouperChek assay to differentiate the highly prized grouper from tilapia, a common illegal substitute.
ENRICHMENT AND PURIFICATION OF CD3+ T-CELLS FROM HUMAN UMBILICAL CORD BLOOD
Quad Technologies

Quad Technologies’ has partnered with the University of Massachusetts Medical School (Worcester, MA, USA) to evaluate the performance of the MagCloudz™ Streptavidin cell separation kit.
Using the Morphologi G3 for evaluating ceramic granules produced by a spray drying process
Malvern Instruments Limited

From the humble cereal bowl to the intricate electronic components in your mobile phone and even body armour, ceramics are found in a diverse range of industries and applications.
Application of microcalorimetry in drug discovery at Exelixis
Malvern Instruments Limited

Understanding the molecular details of drug-target protein interactions is a critical component of the drug discovery process in the modern pharmaceutical industry.
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
Malvern Instruments Limited

The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure and in understanding the factors that affect the function and the stability of antibodies.
Monitoring structure rebuild (thixotropy) following extrusion from a bottle, tube or spray head
Malvern Instruments Limited

A three-step strain/shear rate test was performed on a toothpaste and hair gel to evaluate the rate and extent of elasticity recovery following extrusion from a tube.
Analysis of Demicellization Data from Isothermal Titration Calorimetry
Malvern Instruments Limited


Optimizing Fluid Rheology for Enhanced Oil Recovery Applications: A Case Study
Malvern Instruments Limited

In this case study we present elements of the work carried out by Rafael Hincapie as part of his PhD project at TU Clausthal to better understand how viscoelastic properties of EOR polymers influence oil recovery performance.
Characterization of IgG Monomers & Their Aggregates
Malvern Instruments Limited

A comparison between column calibration & multi-detection SEC.
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