Corporate Banner
Satellite Banner
Automation & Microfluidics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Microarray-on-a-Chip Test for Cystic Fibrosis

Published: Wednesday, July 06, 2011
Last Updated: Tuesday, July 05, 2011
Bookmark and Share
Pre-launch phase of microarray technology based test for rapid simultaneous detection of 25 of the most common mutations causing cystic fibrosis.

Astra Biotech GmbH is in the pre-launch phase of its newly developed test, based on microarray technology, for rapid simultaneous detection of 25 of the most common mutations causing cystic fibrosis in pan-European populations.

This initiative supports Astra Biotech’s aim of facilitating early diagnosis of individuals’ risk factors through innovative assays. In this way long-term effects of a disease can be minimized and patient healthcare standards can be improved.

Cystic fibrosis (CF) is a life-threatening recessive genetic disease which causes severe malfunctioning of the exocrine glands, respiratory system and gastrointestinal tract.

Diagnosis frequently takes place only once symptoms are already obvious, thereby delaying disease management and risking irreversible damage to the vital organs. The median age of survival is around 30 years, with death most commonly due to cardio-respiratory complications.

At present, CF is routinely diagnosed by newborn screening using a blood test and a sweat test, though these can lead to both false positive and false negative results.

For example, carriers of a single mutated copy of the relevant CFTR (cystic fibrosis transmembrane conductance regulator) gene, who will not develop the disease, may test positive; while individuals with mild mutations in both copies of the CFTR gene, who will develop CF, may have a near-normal sweat test.

Astra Biotech has developed a platform providing a much more reliable CF diagnosis, based on best-practice guidelines for molecular genetic diagnosis of cystic fibrosis and CFTR-related disorders. Over 1,500 mutations can contribute to development of these disorders; 4-5 per cent of Caucasian populations carry one or more CF alleles.

Using microarray technology and a microchip designed according to the newest clinical genetic data, the Astra Biotech test enables rapid simultaneous detection of a panel of 25 mutations in the CFTR gene.

These include the most common mutations identified as leading to CF disease in Western European populations, together with 9 mutations most frequently found in Eastern European ethnic groups.

The new cystic fibrosis microarray test ensures reliable detection with high specificity and sensitivity. Applications include CF newborn screening, prenatal diagnostics, carrier testing, and testing of couples with a personal or close family history of CF as recommended by the World Health Organization.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Microarray-on-a-Chip Test for Cystic Fibrosis
Astra Biotech GmbH is in the pre-launch phase of its newly developed test, based on microarray technology, for rapid simultaneous detection of 25 of the most common mutations causing cystic fibrosis in pan-European populations.
Tuesday, December 06, 2011
Scientific News
Measuring Chemistry on a Chip
Researchers developing chemical sensor chip for sample analysis in a lab or monitoring air and water quality in the field.
Automating Genetic Analysis
Researchers are looking to have computers help perform genetic analysis when scientists study a patient's genome to diagnose a disease.
DNA Condensation on a Chip
Carriers of genetic information packed together on a biochip like in nature.
Microchip Tech Improves Nanomaterial Safety Screening
Platform developed at UCLA uses lab-on-a-chip technology to predict how hazardous engineered nanomaterials might be.
Four Key Dynamics Driving Effective Outsourcing Decision Making for Lab Automation OEMs
Laboratory automation device manufacturers need to stay flexible in their outsourcing strategies because their make-versus-buy decisions may change over time.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
'Fixing' Blood Vessel Cells To Diagnose Blood Clotting Disorders
A novel microfluidic device detects how endothelial cells that line vessels contribute to hemostasis.
Replicating the Connection Between Muscles and Nerves
New chip could help test drugs for ALS, other neuromuscular disorders.
Lab-on-a-Chip to Detect Cancer and Diseases at the Nanoscale
IBM scientists will collaborate with the Icahn School of Medicine at Mt. Sinai to test on prostate cancer.
Diagnostic Thread - Weaving the Future?
Researchers have created diagnostic threads that could pave the way for next-gen implantable and wearable diagnostics.
Scroll Up
Scroll Down
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!