Corporate Banner
Satellite Banner
Automation & Microfluidics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Fluxion Biosciences Launches the F1 Giga-Ohm Seal Plates for the IonFlux™ System

Published: Monday, November 14, 2011
Last Updated: Sunday, November 13, 2011
Bookmark and Share
Single-cell, high seal resistance plates provide increased flexibility for kinetic studies and other demanding applications on the IonFlux automated patch clamp system.

Fluxion Biosciences has announced that it has introduced F1 giga-ohm seal plates for the IonFlux automated patch clamp system.

The newly launched F1 plates complement Fluxion’s existing 20-cell ensemble recording plates and are fully compatible with all IonFlux systems.

Users can operate both plate formats interchangeably on either the IonFlux 16 or HT systems.

IonFlux F1 plates are the industry’s first polymeric patch plates to deliver giga-ohm seal performance. This breakthrough, utilizing Fluxion’s expertise in material science, surface treatments, and microfluidics, results in a tight “glass-like” patch seal that approximates traditional manual patch approaches.

The introduction of this new plate format is intended to broaden the utility of the IonFlux System for applications where high fidelity recordings from individual cells are preferred.

These include kinetic analysis, heterogeneous cell populations, endogenous expression systems (i.e. ex-vivo primary cells), and low-expression cells.

The IonFlux system provides functional characterization of ion channels by automating the traditional “patch clamp” technique. This allows compound screening for the promising yet challenging ion channel drug target class in a physiologically relevant context.

The IonFlux automated patch clamp system combines flexibility and simplicity with time and cost savings, and is ideal for a range of ion channel assays requiring 10 to 10,000 or more assays per day.

The IonFlux system utilizes an extremely compact plate reader format, making it ideal for users in both individual research labs and high throughput screening centers.

A broad range of leading academic institutions and biopharmaceutical companies has adopted the IonFlux system globally, including Cornell University, University of Melbourne, University of Michigan, Pfizer, Novartis, Genentech, and Sanofi-Aventis.

With the introduction of F1 giga-ohm seal plates, adoption of the IonFlux system into new applications and laboratories is anticipated to grow significantly.

“The IonFlux system with the original ensemble recording plates is a great solution for a wide range of screening and pharmacology studies”, noted Dr. Cristian Ionescu-Zanetti, Fluxion’s CTO.

Ionescu-Zanetti continued, “However, there are certain applications where individual cell recordings and giga-ohm seals are preferable. We listened to our customers and have responded with the development and introduction of these new F1 plates, which provide high fidelity single-cell recordings for the most demanding applications. Examples are fast voltage gated channel kinetics, leaky channels with weak voltage dependence, and current distributions for heterogeneous cell populations such as stem cell derived cardiomyocytes and ex vivo primary cells. These new plates are fully compatible with all IonFlux systems and users can switch between the two plate formats as their application needs dictate. This really makes the IonFlux system the most versatile automated patch clamp system available.”

Detailed information about Fluxion’s new F1 plates will be available at Fluxion’s product exhibit (Booth #613) at the Society for Neuroscience 2011 conference (November 12-16, Washington, D.C.).


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Research Team from Fred Hutchinson Cancer Center Wins 2010 BioFlux Innovation Award
Group will use BioFlux System for advanced screening applications applicable to women’s reproductive health.
Saturday, September 18, 2010
Ohio State University Researchers Adopt IonFlux 16 Automated Patch Clamp System
First of kind high throughput instrument for research applications enables ion channel studies.
Monday, August 16, 2010
Scientific News
Automated Low Volume Dispensing Trends
Gain a better understanding of the current and future market requirements for fully automated LVD systems.
Blood-brain Barrier on a Chip
Researchers from Vanderbilt University have developed a microfluidic device to study the blood-brain barrier.
'Lab on the Skin' for Sweat Analysis
Northwestern University researchers develop a low-cost wearable electronic device that collects and analyzes sweat for health monitoring.
Peer Review is in Crisis, But Should be Fixed, Not Abolished
After the time to get the science done, peer review has become the slowest step in the process of sharing studies, and some scientists have had enough.
Making Every Cell Matter
New method for encapsulating single cells within microgels could boost efficacy of cell-based therapies and tissue engineering.
Modelling Cigarette Effects with Airway-on-a-Chip
An instrument that smokes cigarettes like a human, and delivers whole smoke to the air space of microfluidic human airway chips, enables new insights into how non-smokers and COPD patients respond to smoke.
Robotic Cleaning Technique Could Automate Neuroscience Research
New robotic cleaning technique allows pipettes used in patch-clamping to be re-used up to 11 or more times.
Lab-on-a-Chip to Help Detect Cancer
In this podcast, we speak to Gustavo Stolovitsky to learn about his career and the work he is doing at IBM Research.
First Entirely 3D-printed Organ-on-a-Chip with Integrated Sensors
New approach to manufacturing may allow researchers to rapidly design organs-on-chips that match the properties of a specific disease or individual patient's cells.
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!