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New White Paper: “Don’t Be Thrown off Balance – Safer Operations in Biofermentation”

Published: Tuesday, September 25, 2012
Last Updated: Tuesday, September 25, 2012
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The white paper explains how recent developments in process analytics can reduce the risk of operator error during fermentation runs, ensure operator safety and increase production process efficiency through simplifying analytical measurements.

METTLER TOLEDO Process Analytics announced the publication of a white paper entitled “Don’t Be Thrown off Balance – Safer Operations in Biofermentation,” discussing how recent developments in process analytics can reduce the risk of operator error during fermentation runs.

 Active Pharmaceutical Ingredients (APIs) produced via biofer­mentation are extremely sensitive to the manufactur­ing process. Whether continuous or fed-batch mode, biofermentation requires careful control of analytical parameters in order to minimize batch inconsistency and prevent batch loss. The goal is to keep parameters such as pH and dissolved oxygen at a constant level or following a predefined course. Howev­er, as a run progresses, cell metabolism and accumula­tion of metabolic side prod­ucts may alter the fermenta­tion medium in an unpre­dictable way, necessitating corrective action. Bioreactors on which several analytical parameters are being monitored can be complex for technicians to operate and therefore carry risks of human error.

METTLER TOLEDO's white paper shows how recent developments in process analytics have simplified analytical measurements on bioreactors and reduced the possibility of mistakes being made. The white paper is available for download at www.mt.com


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