New White Paper: “Don’t Be Thrown off Balance – Safer Operations in Biofermentation”
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METTLER TOLEDO Process Analytics announced the publication of a white paper entitled “Don’t Be Thrown off Balance – Safer Operations in Biofermentation,” discussing how recent developments in process analytics can reduce the risk of operator error during fermentation runs.
Active Pharmaceutical Ingredients (APIs) produced via biofermentation are extremely sensitive to the manufacturing process. Whether continuous or fed-batch mode, biofermentation requires careful control of analytical parameters in order to minimize batch inconsistency and prevent batch loss. The goal is to keep parameters such as pH and dissolved oxygen at a constant level or following a predefined course. However, as a run progresses, cell metabolism and accumulation of metabolic side products may alter the fermentation medium in an unpredictable way, necessitating corrective action. Bioreactors on which several analytical parameters are being monitored can be complex for technicians to operate and therefore carry risks of human error.
METTLER TOLEDO's white paper shows how recent developments in process analytics have simplified analytical measurements on bioreactors and reduced the possibility of mistakes being made. The white paper is available for download at www.mt.com
Active Pharmaceutical Ingredients (APIs) produced via biofermentation are extremely sensitive to the manufacturing process. Whether continuous or fed-batch mode, biofermentation requires careful control of analytical parameters in order to minimize batch inconsistency and prevent batch loss. The goal is to keep parameters such as pH and dissolved oxygen at a constant level or following a predefined course. However, as a run progresses, cell metabolism and accumulation of metabolic side products may alter the fermentation medium in an unpredictable way, necessitating corrective action. Bioreactors on which several analytical parameters are being monitored can be complex for technicians to operate and therefore carry risks of human error.
METTLER TOLEDO's white paper shows how recent developments in process analytics have simplified analytical measurements on bioreactors and reduced the possibility of mistakes being made. The white paper is available for download at www.mt.com
