Corporate Banner
Satellite Banner
Automation & Microfluidics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Recent Progress in Lab-on-a-Chip Technology and Its Potential Application to Clinical Diagnoses

Published: Friday, June 21, 2013
Last Updated: Friday, June 21, 2013
Bookmark and Share
This study presents the construction of the lab-on-a-chip (LOC) system for the miniaturization of conventional laboratory apparatuses.

Abstract
We present the construction of the lab-on-a-chip (LOC) system, a state-of-the-art technology that uses polymer materials (i.e., poly[dimethylsiloxane]) for the miniaturization of conventional laboratory apparatuses, and show the potential use of these microfluidic devices in clinical applications. In particular, we introduce the independent unit components of the LOC system and demonstrate how each component can be functionally integrated into one monolithic system for the realization of a LOC system. In specific, we demonstrate microscale polymerase chain reaction with the use of a single heater, a microscale sample injection device with a disposable plastic syringe and a strategy for device assembly under environmentally mild conditions assisted by surface modification techniques. In this way, we endeavor to construct a totally integrated, disposable microfluidic system operated by a single mode, the pressure, which can be applied on-site with enhanced device portability and disposability and with simple and rapid operation for medical and clinical diagnoses, potentially extending its application to urodynamic studies in molecular level.

This article was published online in the International Neurourology Journal and is free to access.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Integration of Enabling Methods for Automated Flow Preparation of Piperazine-2-Carboxamide
This work describes the application of automation to performing routine research tasks and how the application of remote monitoring can improve safety and efficiency.
Monday, May 19, 2014
All-Aqueous Multiphase Microfluidics
This paper reviews recent progress in the generation of all-aqueous emulsions and jets in microfluidic systems.
Thursday, February 06, 2014
Rapid Sub-attomole MicroRNA Detection on a Portable Microfluidic Chip
Researchers describe two key technologies to solve one of the major issues for point of care testing application.
Thursday, February 06, 2014
Microfluidics for Synthesis of Peptide-Based PET Tracers
Microfluidics is a very promising technology to meet the increased demand for peptide-based PET tracers.
Thursday, January 09, 2014
Microfluidic Separation of Live and Dead Yeast Cells using Reservoir-Based Dielectrophoresis
Cell separation is an essential step in biological research and has important applications in many areas such as environmental monitoring, food production, and pharmaceutical industry.
Friday, September 06, 2013
The Future of Microfluidics for Biomarker Detection
This article outlines the present status of microfluidics for biomarker detection.
Friday, September 06, 2013
Electron Beam Fabrication of a Microfluidic Device for Studying Submicron-Scale Bacteria
This study presents an EBL and poly(dimethylsiloxane) (PDMS) [28] soft-lithography [29] protocol for the fabrication of a micro?uidic device for microbial studies.
Friday, April 26, 2013
Simple Filter Microchip for Rapid Separation of Plasma and Viruses from Whole Blood
Scientists have developed a disposable, pump-free, size exclusion–based filter microchip that can be used for plasma and virus separation from unprocessed whole blood samples in resource-constrained settings.
Wednesday, October 17, 2012
Microfluidics Based Phantoms of Superficial Vascular Network
This paper presents a method for fast prototyping of phantoms simulating a superficial vasculature network, based on microfluidics.
Wednesday, July 11, 2012
Density-Dependent Separation of Encapsulated Cells in a Microfluidic Channel
Cell encapsulation is a highly promising method for forming spherical cell bodies, which can mimic a multi-cellular in-vivo environment, for use as a three-dimensional cell culture model.
Wednesday, June 13, 2012
Sheathless Size-based Acoustic Particle Separation
The separation of particles or cells is critical for many biological and biomedical applications, including cell biology, diagnostics and therapeutics. This paper presents a novel sheathless SSAW based particle separation technique in a microfluidic channel.
Wednesday, May 16, 2012
Fluorescence Detection Methods for Microfluidic Droplet Platforms
This article reports the entire experimental process for detection of single cells and the mapping of mixing processes inside picoliter-volume droplets, including microfluidic chip fabrication, the optical setup and the process of droplet generation and detection.
Wednesday, May 16, 2012
Lipid-based Passivation in Nanofluidics
This study demonstrates the use of lipid bilayers as a passivation layer in nanofluidic networks, consisting of nanochannels and nanoslits, fabricated in fused silica.
Wednesday, May 16, 2012
Microfluidic Chip for Molecular Amplification of Influenza A RNA in Human Respiratory Specimens
This paper demonstrates a proof-of-concept microfluidic chip using clinical specimens collected over a two-year period from patients with suspected influenza.
Wednesday, April 11, 2012
Single-Cell Chemical Lysis on Microfluidic Chips with Arrays of Microwells
This study looks at the looks at a way of accurately analysing individual cells in order to investigate cellular content.
Thursday, March 08, 2012
Scientific News
New Tech Enables Epigenomic Analysis with a Mere 100 Cells
A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer has been developed by researchers at Virginia Tech.
Futuristic Brain Probe Allows for Wireless Control of Neurons
NIH-funded scientists developed an ultra-thin, minimally invasive device for controlling brain cells with drugs and light.
Microfluidic Device Mixes And Matches DNA For Synthetic Biology
Researchers have developed a microfluidic device that quickly builds packages of DNA and delivers them into bacteria or yeast for further testing.
Artificial Pancreas Controls Diabetes
Scientists are reporting the development of an implantable “artificial pancreas” that continuously measures a person’s blood sugar, or glucose, level and can automatically release insulin as needed.
Major Step for Implantable Drug-Delivery Device
MIT spinout signs deal to commercialize microchips that release therapeutics inside the body.
Smart Insulin Patch Could Replace Painful Injections for Diabetes
A joint effort between diabetes doctors and biomedical engineers could revolutionize how people with diabetes keep their blood sugar levels in check.
The Secrets of Secretion
Researchers have hacked nature's blueprints to create a new technology that could have broad-reaching impact on drug delivery systems and self-healing and anti-fouling materials.
New Tool on Horizon for Surgeons Treating Cancer Patients
Surgeons could know while their patients are still on the operating table if a tissue is cancerous, according to researchers.
Heartbeat on a Chip Could Improve Pharmaceutical Tests
A gravity-powered chip that can mimic a human heartbeat outside the body could advance pharmaceutical testing and open new possibilities in cell culture because it can mimic fundamental physical rhythms.
Unravelling the Mysteries of Carbonic Acid
Researchers have shown how gaseous carbon dioxide molecules are solvated by water to initiate the proton transfer chemistry that produces carbonic acid and bicarbonate.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!