Corporate Banner
Satellite Banner
Automation & Microfluidics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Harvard's Wyss Institute and AstraZeneca Announce Collaboration on Organs-on-Chips

Published: Wednesday, October 23, 2013
Last Updated: Wednesday, October 23, 2013
Bookmark and Share
Collaboration will leverage the Institute's Organs-on-Chips technologies to better predict safety of drugs in humans.

Human Organs-on-Chips are composed of a clear, flexible polymer about the size of a computer memory stick, and contain hollow microfluidic channels lined by living human cells -- allowing researchers to recreate the physiological and mechanical functions of the organ, and to observe what happens in real time. The goal is to provide more predictive and useful measures of the efficacy and safety of potential new drugs in humans -- which could represent an important step in reducing the need for traditional animal testing.

The collaboration with AstraZeneca will apply the Institute's advances in the development and validation of human Organs-on-Chips to develop new animal versions. These animal organs-on-chips will be tested alongside the human models to further understand the extent to which drug safety results in animals can predict how an investigational drug might impact humans. The testing of a potential new medicine on animals is a small but necessary step in bringing this medicine to market. Regulators require safety data from animal studies before giving the required approval to test a new medicine in humans. However, animal tests do not always accurately predict what will happen in humans.

"Comparing human and animal Organs-on-Chips is an exciting example of what we call 'predictive science,' in which we harness the power of technology to better understand how a medicine might ultimately impact patients and in some cases speed the delivery of innovative new medicines," said Stefan Platz, Vice President Drug Safety and Metabolism at AstraZeneca. "The Wyss Institute's technology could play a critical role in both improving patient safety and reducing the need for animal testing."

In February, Wyss Founding Director Don Ingber, M.D., Ph.D., who leads the Organs-on-Chips research program, received the prestigious 3Rs Prize from the UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research for the lung-on-a-chip. In March the Society of Toxicology awarded him the Leading Edge in Basic Science Award for his "seminal scientific contributions and advances to understanding fundamental mechanisms of toxicity."

"This collaboration with AstraZeneca will help us to validate this approach as a potential alternative to animal testing by carrying out direct comparisons between organ chips containing cells from animals versus humans in organ-mimicking environments," said Ingber. "If successful, this effort should lead to ways to streamline the drug development process and more effectively predict safety of drugs and chemicals in humans."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Wyss Institute Awarded DARPA Contract to Further Advance Sepsis Therapeutic Device
DARPA gives award to further advance a blood-cleansing technology and help accelerate its translation to humans as a new type of sepsis therapy.
Thursday, March 28, 2013
Wyss Institute Models a Human Disease in an Organ-on-a-Chip
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have mimicked pulmonary edema in a microchip lined by living human cells, as reported today in the journal Science Translation Medicine.
Friday, November 09, 2012
Scientific News
Analysing 10,000 Cells Simultaneously
New techniquethat traps 10,000 cells on a single chip has potential for cancer screening for individuals.
Puttng Cells Through Their Paces
An obstacle course for human lung cells could be the answer for better testing the effectiveness of potential new drugs.
Dolomite Bio’s Single Cell RNA-Seq System Enables High Speed Encapsulation
Dolomite Bio has developed the Single-Cell RNA-Seq System for efficient, high throughput single cell transcriptomics.
NASA's DNA Sequencing in Space is a Success
DNA has been sequenced in space for the first time ever for the Biomolecule Sequencer investigation, using the MinION sequencing device.
Lab-on-a-Stick: Miniaturised Clinical Testing For Fast Detection Of Antibiotic Resistance
A portable power-free test for the rapid detection of bacterial resistance to antibiotics has been developed by academics at Loughborough University and the University of Reading.
Breast Cancer Cells Found To Switch Molecular Characteristics
Spontaneous interconversion between HER2-positive and HER2-negative states could contribute to progression, treatment resistance in breast cancer.
Measuring Chemistry on a Chip
Researchers developing chemical sensor chip for sample analysis in a lab or monitoring air and water quality in the field.
Automating Genetic Analysis
Researchers are looking to have computers help perform genetic analysis when scientists study a patient's genome to diagnose a disease.
DNA Condensation on a Chip
Carriers of genetic information packed together on a biochip like in nature.
Microchip Tech Improves Nanomaterial Safety Screening
Platform developed at UCLA uses lab-on-a-chip technology to predict how hazardous engineered nanomaterials might be.
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!