Corporate Banner
Satellite Banner
Automation & Microfluidics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Harvard's Wyss Institute and AstraZeneca Announce Collaboration on Organs-on-Chips

Published: Wednesday, October 23, 2013
Last Updated: Wednesday, October 23, 2013
Bookmark and Share
Collaboration will leverage the Institute's Organs-on-Chips technologies to better predict safety of drugs in humans.

Human Organs-on-Chips are composed of a clear, flexible polymer about the size of a computer memory stick, and contain hollow microfluidic channels lined by living human cells -- allowing researchers to recreate the physiological and mechanical functions of the organ, and to observe what happens in real time. The goal is to provide more predictive and useful measures of the efficacy and safety of potential new drugs in humans -- which could represent an important step in reducing the need for traditional animal testing.

The collaboration with AstraZeneca will apply the Institute's advances in the development and validation of human Organs-on-Chips to develop new animal versions. These animal organs-on-chips will be tested alongside the human models to further understand the extent to which drug safety results in animals can predict how an investigational drug might impact humans. The testing of a potential new medicine on animals is a small but necessary step in bringing this medicine to market. Regulators require safety data from animal studies before giving the required approval to test a new medicine in humans. However, animal tests do not always accurately predict what will happen in humans.

"Comparing human and animal Organs-on-Chips is an exciting example of what we call 'predictive science,' in which we harness the power of technology to better understand how a medicine might ultimately impact patients and in some cases speed the delivery of innovative new medicines," said Stefan Platz, Vice President Drug Safety and Metabolism at AstraZeneca. "The Wyss Institute's technology could play a critical role in both improving patient safety and reducing the need for animal testing."

In February, Wyss Founding Director Don Ingber, M.D., Ph.D., who leads the Organs-on-Chips research program, received the prestigious 3Rs Prize from the UK's National Centre for the Replacement, Refinement and Reduction of Animals in Research for the lung-on-a-chip. In March the Society of Toxicology awarded him the Leading Edge in Basic Science Award for his "seminal scientific contributions and advances to understanding fundamental mechanisms of toxicity."

"This collaboration with AstraZeneca will help us to validate this approach as a potential alternative to animal testing by carrying out direct comparisons between organ chips containing cells from animals versus humans in organ-mimicking environments," said Ingber. "If successful, this effort should lead to ways to streamline the drug development process and more effectively predict safety of drugs and chemicals in humans."


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Wyss Institute Awarded DARPA Contract to Further Advance Sepsis Therapeutic Device
DARPA gives award to further advance a blood-cleansing technology and help accelerate its translation to humans as a new type of sepsis therapy.
Thursday, March 28, 2013
Wyss Institute Models a Human Disease in an Organ-on-a-Chip
Researchers at the Wyss Institute for Biologically Inspired Engineering at Harvard University have mimicked pulmonary edema in a microchip lined by living human cells, as reported today in the journal Science Translation Medicine.
Friday, November 09, 2012
Scientific News
Automated Low Volume Dispensing Trends
Gain a better understanding of the current and future market requirements for fully automated LVD systems.
Blood-brain Barrier on a Chip
Researchers from Vanderbilt University have developed a microfluidic device to study the blood-brain barrier.
'Lab on the Skin' for Sweat Analysis
Northwestern University researchers develop a low-cost wearable electronic device that collects and analyzes sweat for health monitoring.
Peer Review is in Crisis, But Should be Fixed, Not Abolished
After the time to get the science done, peer review has become the slowest step in the process of sharing studies, and some scientists have had enough.
Making Every Cell Matter
New method for encapsulating single cells within microgels could boost efficacy of cell-based therapies and tissue engineering.
Modelling Cigarette Effects with Airway-on-a-Chip
An instrument that smokes cigarettes like a human, and delivers whole smoke to the air space of microfluidic human airway chips, enables new insights into how non-smokers and COPD patients respond to smoke.
Robotic Cleaning Technique Could Automate Neuroscience Research
New robotic cleaning technique allows pipettes used in patch-clamping to be re-used up to 11 or more times.
Lab-on-a-Chip to Help Detect Cancer
In this podcast, we speak to Gustavo Stolovitsky to learn about his career and the work he is doing at IBM Research.
First Entirely 3D-printed Organ-on-a-Chip with Integrated Sensors
New approach to manufacturing may allow researchers to rapidly design organs-on-chips that match the properties of a specific disease or individual patient's cells.
3D-Printing in Science: Conference Co-Staged with LABVOLUTION
LABVOLUTION 2017 will have an added highlight of a simultaneous conference, "3D-Printing in Science".
Scroll Up
Scroll Down
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!