Corporate Banner
Satellite Banner
Automation & Microfluidics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

New Lab-on-a-Chip Device Overcomes Miniaturisation Problems

Published: Thursday, May 01, 2014
Last Updated: Thursday, May 01, 2014
Bookmark and Share
The novel technique involves printing a pattern of miniscule droplets of a special solvent onto a gold-coated or glass surface.

UNSW chemists have invented a new type of tiny lab-on-a-chip device that could have a diverse range of applications, including to detect toxic gases, fabricate integrated circuits and screen biological molecules.

 “We use a class of ‘green’ solvents called ionic liquids, which are salts that are liquid at room temperature.  They are non-volatile, so this overcomes one of the main problems in making useful miniaturised devices - rapid evaporation of the solvents on the chip,” says Dr Chuan Zhao, senior author of the study.

“The versatility of our chips means they could have a wide range of prospective functions, such as for use in fast and accurate hand-held sensors for environmental monitoring, medical diagnosis and process control in manufacturing.”

The research is published in the journal Nature Communications. It was carried out by Dr Zhao, Christian Gunawan and Mengchen Ge from the UNSW School of Chemistry.

Lab-on-a- chip devices, where chemical reactions are carried out on a miniature scale, are under intensive development because they offer the promise of faster reaction times, reduced use of materials and high yields of product.

Evaporation of solvents on the chip, however, is a big problem because this can affect the concentration of substances and disrupt the reactions. Attempted solutions include containing the solvents within tiny channels or “walls”, and having reservoirs to store extra solvent on the chip.

The “wall-less” design developed by the UNSW team - using non-volatile ionic liquids as solvents to fabricate a microarray of droplets chemically anchored to the chip - has several significant advantages.

“Ionic liquids are designer solvents and have wide application. We can now carry out many reactions or analytical procedures in ionic liquids at the micro-scale on a chip with enhanced yields and efficiency,” says Dr Zhao.

“These microarray chips can be easily produced in high numbers and are very stable. They can survive being turned upside down and heated to 50 degrees and some can even survive being immersed in another liquid. These properties will be important for commercial applications, including storage and transportation of microchips.”

The droplets of ionic liquid are about 50 micrometres across (about half the width of a human hair) and 10 micrometres high.

The UNSW researchers demonstrated several potential uses of the microarrays.

They showed the tiny droplets can act as rapid, sensitive monitors of the presence of a gas, due to their small volume.

They also demonstrated that metal salts dissolved in the droplets could be electrically deposited as microstructures, a technique which could be of use in fabrication of integrated circuits.

Some biological molecules added to the droplets also remained stable and active, opening up the possibility of using the microarrays for diagnostic purposes.



Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
Capturing Cell Growth in 3-D
Spinout’s microfluidics device better models how cancer and other cells interact in the body.
Device May Detect Urinary Tract Infections Faster
A Lab-on-a-Disc platform developed by a German and Irish team of researchers dramatically cut the time to detect bacterial species that cause urinary tract infections -- a major cause of sepsis.
Automation Abound at AACC in Atlanta
Discover the latest breakthroughs, trends and products from the AACC Annual Meeting & Clinical Lab Expo.
Real-Time Data for Cancer Therapy
Biochemical sensor implanted at initial biopsy could allow doctors to better monitor and adjust cancer treatments.
Lab-on-a-Chip Offers Promise for TB and Asthma Patients
A device to mix liquids using ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Paving the way to Better Ovarian Cancer Diagnosis
Aïcha BenTaieb will present her invention for automated identification of ovarian cancer’s many subtypes at an international conference this fall.
New Tech Enables Epigenomic Analysis with a Mere 100 Cells
A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer has been developed by researchers at Virginia Tech.
Futuristic Brain Probe Allows for Wireless Control of Neurons
NIH-funded scientists developed an ultra-thin, minimally invasive device for controlling brain cells with drugs and light.
Microfluidic Device Mixes And Matches DNA For Synthetic Biology
Researchers have developed a microfluidic device that quickly builds packages of DNA and delivers them into bacteria or yeast for further testing.
Scroll Up
Scroll Down
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!