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Direct On-chip Storage and Release of Liquid Reagents for Diagnostic Lab-on-a-Chip Devices
Daniel Czurratis*, Thomas Brettschneider*, Yvonne Beyl*, Sven Zinober*, Franz Lärmer*, Roland Zengerle**

We present a direct on-chip storage and release of liquid reagents for diagnostic lab-on-a-chip devices. Reagent release is pressure driven and realized by braking up a barrier film through a deflection of a flexible membrane.

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Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
Chad I. Rogers, Joseph B. Oxborrow, Long-Fang Tsai, Gregory P. Nordin, and Adam T. Woolley

Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated.

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Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
Chad I. Rogers, Joseph B. Oxborrow, Long-Fang Tsai, Gregory P. Nordin, and Adam T. Woolley

Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated.

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Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
Chad I. Rogers, Joseph B. Oxborrow, Long-Fang Tsai, Gregory P. Nordin, and Adam T. Woolley

Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated.

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Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system
Anne F Hammerstein, Diana Caracino, and Paul Wylie

The requirement for better in-vitro models that are compatible with high-throughput screening campaigns has led to the development of 3D cell cultures models, especially muliticellular spheroids, which retain many of the morphological and genetic traits of tumours.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.

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Combining low and high volume liquid handling capabilities for ADME screening
Joby Jenkins, Kevin Moore, Stephen Fowler, Pascal Schenk

In this study we demonstrate the integration of two liquid handlers to extend the volume dispensing range creating low-volume assay-ready plates with high accuracy and precision. This was then successfully applied to a CYP inhibition assay.

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A Distinctive Analysis of Fluid Flow Behaviour in an AC Electroosmotic Micropump
Nurul Amziah Md Yunus, Farideh Abhari, Mohd Nizar Hamidon, Zurina Zainal Abidin, Izhal Abdul Halin, Gerard H. Markx and Nicolas G. Green

Microfluidic systems are used for chemical and biological analyses, sensing, drug delivery and molecular separation.

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Low-cost “Plug & Play” On-Chip Valve and Pump for Thermoplastic Microfluidics
Mousavi Shaegh Seyed Ali, Wang Zhenfeng, Toh Guek Geok, Soh Yong Chear

Scientists have developed a novel on-chip valving solution for thermoplastic microfluidic devices, which is reliable, easy to implement, and has low-cost fabrication.

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A novel DNA amplification method based on silicon microring resonator for rapid detection of genetic alteration in the point-of care (POC) field of cancers

Nucleic acid testing plays a critical role in molecular diagnosis[1-2]. Due to the low amounts of DNA obtained in clinical samples, the amplification of DNA is an essential step in most NAT methods [3].

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Showing Results 91 - 100 of 227
Scientific News
The Changing Tides of the In Vitro Diagnostics Market
With the increasing focus in personalized medicine, diagnostics plays a crucial role in patient monitoring.
Capturing Cell Growth in 3-D
Spinout’s microfluidics device better models how cancer and other cells interact in the body.
Device May Detect Urinary Tract Infections Faster
A Lab-on-a-Disc platform developed by a German and Irish team of researchers dramatically cut the time to detect bacterial species that cause urinary tract infections -- a major cause of sepsis.
Automation Abound at AACC in Atlanta
Discover the latest breakthroughs, trends and products from the AACC Annual Meeting & Clinical Lab Expo.
Real-Time Data for Cancer Therapy
Biochemical sensor implanted at initial biopsy could allow doctors to better monitor and adjust cancer treatments.
Lab-on-a-Chip Offers Promise for TB and Asthma Patients
A device to mix liquids using ultrasonics is the first and most difficult component in a miniaturized system for low-cost analysis of sputum from patients with pulmonary diseases such as tuberculosis and asthma.
Paving the way to Better Ovarian Cancer Diagnosis
Aïcha BenTaieb will present her invention for automated identification of ovarian cancer’s many subtypes at an international conference this fall.
New Tech Enables Epigenomic Analysis with a Mere 100 Cells
A new technology that will dramatically enhance investigations of epigenomes, the machinery that turns on and off genes and a very prominent field of study in diseases such as stem cell differentiation, inflammation and cancer has been developed by researchers at Virginia Tech.
Futuristic Brain Probe Allows for Wireless Control of Neurons
NIH-funded scientists developed an ultra-thin, minimally invasive device for controlling brain cells with drugs and light.
Microfluidic Device Mixes And Matches DNA For Synthetic Biology
Researchers have developed a microfluidic device that quickly builds packages of DNA and delivers them into bacteria or yeast for further testing.
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