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Direct On-chip Storage and Release of Liquid Reagents for Diagnostic Lab-on-a-Chip Devices
Daniel Czurratis*, Thomas Brettschneider*, Yvonne Beyl*, Sven Zinober*, Franz Lärmer*, Roland Zengerle**

We present a direct on-chip storage and release of liquid reagents for diagnostic lab-on-a-chip devices. Reagent release is pressure driven and realized by braking up a barrier film through a deflection of a flexible membrane.

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Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
Chad I. Rogers, Joseph B. Oxborrow, Long-Fang Tsai, Gregory P. Nordin, and Adam T. Woolley

Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated.

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Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
Chad I. Rogers, Joseph B. Oxborrow, Long-Fang Tsai, Gregory P. Nordin, and Adam T. Woolley

Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated.

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Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
Chad I. Rogers, Joseph B. Oxborrow, Long-Fang Tsai, Gregory P. Nordin, and Adam T. Woolley

Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated.

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Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system
Anne F Hammerstein, Diana Caracino, and Paul Wylie

The requirement for better in-vitro models that are compatible with high-throughput screening campaigns has led to the development of 3D cell cultures models, especially muliticellular spheroids, which retain many of the morphological and genetic traits of tumours.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.

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Combining low and high volume liquid handling capabilities for ADME screening
Joby Jenkins, Kevin Moore, Stephen Fowler, Pascal Schenk

In this study we demonstrate the integration of two liquid handlers to extend the volume dispensing range creating low-volume assay-ready plates with high accuracy and precision. This was then successfully applied to a CYP inhibition assay.

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A Distinctive Analysis of Fluid Flow Behaviour in an AC Electroosmotic Micropump
Nurul Amziah Md Yunus, Farideh Abhari, Mohd Nizar Hamidon, Zurina Zainal Abidin, Izhal Abdul Halin, Gerard H. Markx and Nicolas G. Green

Microfluidic systems are used for chemical and biological analyses, sensing, drug delivery and molecular separation.

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Low-cost “Plug & Play” On-Chip Valve and Pump for Thermoplastic Microfluidics
Mousavi Shaegh Seyed Ali, Wang Zhenfeng, Toh Guek Geok, Soh Yong Chear

Scientists have developed a novel on-chip valving solution for thermoplastic microfluidic devices, which is reliable, easy to implement, and has low-cost fabrication.

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A novel DNA amplification method based on silicon microring resonator for rapid detection of genetic alteration in the point-of care (POC) field of cancers

Nucleic acid testing plays a critical role in molecular diagnosis[1-2]. Due to the low amounts of DNA obtained in clinical samples, the amplification of DNA is an essential step in most NAT methods [3].

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Showing Results 91 - 100 of 227
Scientific News
Toxicity Testing With Cultured Liver Cells
Microreactor replaces animal testing.
Study Validates Analysis of Copy Number Variation in Miniaturized Reaction Volumes
Data shows that accurate and reproducible CNV results can be produced with IntelliQube using the Array Tape® consumable.
Organs on Chips
Combining 3D cell culture with microfluidics, organs-on-chips could revolutionize toxicology testing for pharmaceuticals, foods, cosmetics, pesticides, and industrial chemicals.
Finding the Needle in a Microbial Haystack
After developing a novel investigational technology called PathoChip that can rapidly identify elusive microorganisms, a team of Penn Medicine researchers recently succeeded for the first time in identifying a pathogen in a patient sample, demonstrating the proof of principle that this technology can be used to identify pathogens in human disease.
Organ-on-a-Chip
In a step toward personalized drug testing, researchers coax human stem cells to form complex tissues.
Diagnosing Cancer from a Single Drop of Blood
What if a physician could effectively diagnose cancer from one drop of a patient’s blood?
Study Reveals Shared Behavior of Microbes And Electrons
Bacteria streaming through a lattice behave like electrons in a magnetic material.
Study Reveals Shared Behavior of Microbes and Electrons
Bacteria streaming through a lattice behave like electrons in a magnetic material.
Detecting When and Why Deadly Blood Clots Form
New bioinspired blood coagulation assay is more sensitive than existing assays and could one day be used to diagnose rare bleeding disorders and prevent toxic effects of anticoagulant and antiplatelet drugs.
Tracing a Cellular Family Tree
New technique allows tracking of gene expression over generations of cells as they specialize.
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