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Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
Chad I. Rogers, Joseph B. Oxborrow, Long-Fang Tsai, Gregory P. Nordin, and Adam T. Woolley

Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated.

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Polymerized Poly(ethylene glycol) Diacrylate Microfluidic Membrane Valves
Chad I. Rogers, Joseph B. Oxborrow, Long-Fang Tsai, Gregory P. Nordin, and Adam T. Woolley

Polymerized poly(ethylene glycol) diacrylate (poly-PEGDA) was fabricated into pneumatically controlled, non-elastomeric membrane valves as a nonspecific adsorption resistant alternative to polydimethylsiloxane valves. Temporal response, valve closure, and long-term durability of these poly-PEGDA valves were evaluated.

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Rapid analysis of 3D tumour spheroids in soft agar and on ultra-low attachment plates using a laser scanning imaging system
Anne F Hammerstein, Diana Caracino, and Paul Wylie

The requirement for better in-vitro models that are compatible with high-throughput screening campaigns has led to the development of 3D cell cultures models, especially muliticellular spheroids, which retain many of the morphological and genetic traits of tumours.
Here we describe the formation of such spheroids by two methods: on ultra-low attachment plates and in semi-solid agarose. Both methods are compatible with 96- and 384-well microplate formats.

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Combining low and high volume liquid handling capabilities for ADME screening
Joby Jenkins, Kevin Moore, Stephen Fowler, Pascal Schenk

In this study we demonstrate the integration of two liquid handlers to extend the volume dispensing range creating low-volume assay-ready plates with high accuracy and precision. This was then successfully applied to a CYP inhibition assay.

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A Distinctive Analysis of Fluid Flow Behaviour in an AC Electroosmotic Micropump
Nurul Amziah Md Yunus, Farideh Abhari, Mohd Nizar Hamidon, Zurina Zainal Abidin, Izhal Abdul Halin, Gerard H. Markx and Nicolas G. Green

Microfluidic systems are used for chemical and biological analyses, sensing, drug delivery and molecular separation.

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Low-cost “Plug & Play” On-Chip Valve and Pump for Thermoplastic Microfluidics
Mousavi Shaegh Seyed Ali, Wang Zhenfeng, Toh Guek Geok, Soh Yong Chear

Scientists have developed a novel on-chip valving solution for thermoplastic microfluidic devices, which is reliable, easy to implement, and has low-cost fabrication.

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A novel DNA amplification method based on silicon microring resonator for rapid detection of genetic alteration in the point-of care (POC) field of cancers

Nucleic acid testing plays a critical role in molecular diagnosis[1-2]. Due to the low amounts of DNA obtained in clinical samples, the amplification of DNA is an essential step in most NAT methods [3].

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Rapid Concentration of Particles in Microfluidics using AC Electrothermal Effect with Laser Illumination

In this study, the formation of a toroidal microvortex by AC electrothermal (ACET) effect was numerically visualized using COMSOL v4.2a multiphysics software. AC voltage was applied to the two parallel electrodes in a microchannel to generate temperature gradient in the fluids.

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Microfluidic analysis of amino acids using aminoacyl-tRNA synthetase coupled with spectrophotometric detection

Analyses of free amino acids in biological fluids?—?such as urine and plasma?—?can be useful in determining disease status in clinical diagnoses [1]. In the food industry, unique changes in amino acid concentrations are useful markers of freshness, nutrition, and taste.

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Showing Results 101 - 110 of 235
Scientific News
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Releasing Cancer Cells for Better Analysis
A new device developed at the University of Michigan could provide a non-invasive way to monitor the progress of an advanced cancer treatment.
Lab-on-a-Chip for Detecting Glucose
By integrating microfluidic chips with fiber optic biosensors, researchers in China are creating ultrasensitive lab-on-a-chip devices to detect glucose levels.
Soy Shows Promise as Natural Anti-Microbial Agent
Soy isoflavones and peptides may inhibit the growth of microbial pathogens that cause food-borne illnesses, according to a new study from University of Guelph researchers.
Soy Shows Promise as Natural Anti-Microbial Agent
Researchers from University of Guelph show that soy isoflavones and peptides could be used to reduce microbial contamination of food.
Parsortix Demonstrates Benefits Over Marker-Based Systems
Research published online in the International Journal of Cancer, shows the ParsortixTM System efficiently captures and harvests intact, viable circulating tumour cells (CTCs), including EpCAM-negative CTCs, to allow for broader downstream CTC analysis.
Experimental Therapy For Brain Cancer Could Prevent Drug Resistance
Information from penny-sized microfluidic chips allowed researchers to anticipate resistance to cancer treatment.
3D Printing of Lego Fluidics
Study shows how 3D printing can open up microfluidic technology to a wider audience.
New Method to Preserve Device to Monitor HIV Treatment
Inspired by pregnancy tests, scientists have developed a method to store microfluidic devices for months without refrigeration, giving developing countries an inexpensive and reliable way to treat patients.
Migration Creates Cancer Cell Vulnerabilities
Scientists found that migration can damage cancer cells’ nuclei and DNA, requiring repairs for their survival. The results may open new avenues for targeting metastatic cancer.
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