Thursday, May 17, 2012
Technology Networks
Technology Networks
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 | miRNA Replacement Therapy in Cancer through Polyplex-Mediated miRNA Delivery In Vivo Professor Achim Aigner, Institute of Pharmacology / bpc, Philipps-University Marburg, speaking at RNAi Europe 2011. |
 | Biotests for Hazard Characterization of Waste Dr Reinhilde Weltens, Vito, speaking at Advances in Biosensors and Biodetection. |
Emerging Pharmaceutical Markets 2012
Select Biosciences Ltd
The report covers all the key aspects of the various emerging pharmaceutical markets and has broadly outlined the factors that are affecting the industry. The report also provides current and predicted future performance of the pharmaceutical market in different regions of the world.
In Vivo Preclinical Imaging Trends 2011
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on in vivo preclinical imaging carried out in January 2011.
Adme/Tox Technologies
RI Technologies
This market insight report on ADME/Tox Technologies covers both products and services used in the ADME/Tox industry. Predictive technologies analyzed include In vivo, In vitro, and In silico. Related technologies such as High Throughput Screening (HTS), and cell based assays are also analyzed. Market projections and estimates are illustrated by region and by technology.
Preclinical Models: Innovative solutions to accelerate drug discovery and development
Business Insights
Preclinical models are developed to test lead compounds for toxicity and efficacy. They are valuable tools for minimizing development costs and reducing failures prior to the commencement of human trials. Problems with traditional animal models such as cost, ethics and suitability have prompted researchers to develop new models and systems to overcome these disadvantages.
Stem Cells Market Trends 2010: Drug Discovery/Toxicity Screening and Regenerative Medicine
Select Biosciences Ltd
This market trends report from Select Biosciences presents the results from our latest industry tracking completed in March 2010. The data presented herein are based on primary market surveys from a worldwide respondent pool of industry participants active in the stem cells field.
Select Biosciences Ltd
The report covers all the key aspects of the various emerging pharmaceutical markets and has broadly outlined the factors that are affecting the industry. The report also provides current and predicted future performance of the pharmaceutical market in different regions of the world.
In Vivo Preclinical Imaging Trends 2011
HTStec
This market report summarizes the results of HTStec’s industry-wide global web-based benchmarking survey on in vivo preclinical imaging carried out in January 2011.
Adme/Tox Technologies
RI Technologies
This market insight report on ADME/Tox Technologies covers both products and services used in the ADME/Tox industry. Predictive technologies analyzed include In vivo, In vitro, and In silico. Related technologies such as High Throughput Screening (HTS), and cell based assays are also analyzed. Market projections and estimates are illustrated by region and by technology.
Preclinical Models: Innovative solutions to accelerate drug discovery and development
Business Insights
Preclinical models are developed to test lead compounds for toxicity and efficacy. They are valuable tools for minimizing development costs and reducing failures prior to the commencement of human trials. Problems with traditional animal models such as cost, ethics and suitability have prompted researchers to develop new models and systems to overcome these disadvantages.
Stem Cells Market Trends 2010: Drug Discovery/Toxicity Screening and Regenerative Medicine
Select Biosciences Ltd
This market trends report from Select Biosciences presents the results from our latest industry tracking completed in March 2010. The data presented herein are based on primary market surveys from a worldwide respondent pool of industry participants active in the stem cells field.
Pharmacokinetics, Metabolism and Toxicity of Carbon Nanotubes for Biomedical Purposes
This study reviews the updated data of CNTs from the biomedical view with focus on the pharmacokinetics, metabolism and toxicity of CNTs in vivo.
Fall in Deaths Following Withdrawal of Pain Killer
Reduction in deaths after withdrawn of pain-relief drug co-proxamol in UK.
Urinary Excretion of Platinum, Arsenic and Selenium of Cancer Patients Treated with Platinum-Based Drugs
Arsenic exposure increases the risk of non-cancerous and cancerous diseases. This study characterised the short-term urinary excretion amounts of arsenic, selenium and platinum in 24-h urine samples from patients with lung cancer and those with other types of cancer.
Urinary Excretion of Platinum, Arsenic and Selenium of Cancer Patients Treated with Platinum-Based Drugs
Arsenic exposure increases the risk of non-cancerous and cancerous diseases. This study characterised the short-term urinary excretion amounts of arsenic, selenium and platinum in 24-h urine samples from patients with lung cancer and those with other types of cancer.
Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project
The main barrier for a new drug to enter into clinical development is the preclinical evaluation of toxicity. This project aims to be a database consisting of preclinical toxicity data for drug compounds or candidates extracted from, previously unpublished, legacy reports.
Real-Time Visualization and Quantitation of Vascular Permeability In Vivo: Implications for Drug Delivery
This paper presents an integrated method to visualize and quantify the real-time dynamics of dextrans in a shell-less chick chorioallantoic (CAM) model.
Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Nanomolar Potency
This article looks at prediction of cancer drug efficacy in its ultimate user, the human patient and reviews current knowledge followed by illustrative examples that, in the absence of definitive data, provide an empirical perspective.
Direct Drug Metabolism Monitoring in a Live Single Hepatic Cell by Video Mass Spectrometry
This study of live single-cell level drug metabolism analysis opens the possibility of speedy, low-cost and site-specific monitoring of drug metabolism and a useful tool for single-cell tailored medicine using biopsied cells.
Evaluation of Drug Administration Errors in a Teaching Hospital
The evaluation and improvement of drug administration process are key elements in patient safety. Researchers directly observed the frequency, type, potential clinical significance and determinants of drug administration errors detected in adult in-patients, with the aim to overcome methodological limitations.
Global Patterns of Genetic Diversity and Signals of Natural Selection for Human ADME Genes
This study is the first to systematically investigate worldwide population differentiation and potential signals of natural selection in a comprehensive list of ADME genes.
This study reviews the updated data of CNTs from the biomedical view with focus on the pharmacokinetics, metabolism and toxicity of CNTs in vivo.
Fall in Deaths Following Withdrawal of Pain Killer
Reduction in deaths after withdrawn of pain-relief drug co-proxamol in UK.
Urinary Excretion of Platinum, Arsenic and Selenium of Cancer Patients Treated with Platinum-Based Drugs
Arsenic exposure increases the risk of non-cancerous and cancerous diseases. This study characterised the short-term urinary excretion amounts of arsenic, selenium and platinum in 24-h urine samples from patients with lung cancer and those with other types of cancer.
Urinary Excretion of Platinum, Arsenic and Selenium of Cancer Patients Treated with Platinum-Based Drugs
Arsenic exposure increases the risk of non-cancerous and cancerous diseases. This study characterised the short-term urinary excretion amounts of arsenic, selenium and platinum in 24-h urine samples from patients with lung cancer and those with other types of cancer.
Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project
The main barrier for a new drug to enter into clinical development is the preclinical evaluation of toxicity. This project aims to be a database consisting of preclinical toxicity data for drug compounds or candidates extracted from, previously unpublished, legacy reports.
Real-Time Visualization and Quantitation of Vascular Permeability In Vivo: Implications for Drug Delivery
This paper presents an integrated method to visualize and quantify the real-time dynamics of dextrans in a shell-less chick chorioallantoic (CAM) model.
Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Nanomolar Potency
This article looks at prediction of cancer drug efficacy in its ultimate user, the human patient and reviews current knowledge followed by illustrative examples that, in the absence of definitive data, provide an empirical perspective.
Direct Drug Metabolism Monitoring in a Live Single Hepatic Cell by Video Mass Spectrometry
This study of live single-cell level drug metabolism analysis opens the possibility of speedy, low-cost and site-specific monitoring of drug metabolism and a useful tool for single-cell tailored medicine using biopsied cells.
Evaluation of Drug Administration Errors in a Teaching Hospital
The evaluation and improvement of drug administration process are key elements in patient safety. Researchers directly observed the frequency, type, potential clinical significance and determinants of drug administration errors detected in adult in-patients, with the aim to overcome methodological limitations.
Global Patterns of Genetic Diversity and Signals of Natural Selection for Human ADME Genes
This study is the first to systematically investigate worldwide population differentiation and potential signals of natural selection in a comprehensive list of ADME genes.
Plexpress Announces Collaboration with Admescope
CRO to offer TRAC gene expression analysis for pre-clinical ADME-Tox studies.
Plexpress and SBW Partner to Offer TRAC Gene Expression Analysis
CRO adds TRAC to service portfolio for pre-clinical ADME-Tox studies.
Astex Pharmaceuticals Reports 2012 First Quarter Financial Results
Reports first quarter net income of $4.2 million.
Seward Recruits European Sales Manager for Laboratory Sample Preparation Products
Seward’s European customers and distribution network to benefit from enhanced support.
ELRIG Announces Speaker Programme for Drug Discovery 2012 Conference
The 6th Annual Drug Discovery Conference, in collaboration with SLAS, will be held at Manchester Central Convention Complex on 5th – 6th September 2012.
Luminex Corporation Expands Life Science and Biodefense Groups
Two dedicated groups advance Luminex leadership in scientific research and public safety.
Plexpress Secures $2.3M to Commercialize TRAC High-Content Gene Expression Analysis Platform
Company targets applications including companion diagnostics and ADMET.
Takeda and Metabolon Initiate Research Collaboration
Multiyear research alliance to discover novel targets and biomarkers.
GSK Provides Update on Corporate Responsibility Commitments in 2011 Report
Company publishes its Corporate Responsibility Report, in which it reiterates its commitment to operate responsibly, openly and transparently and sets out advances made on this agenda during 2011.
Astex Pharmaceuticals Announces Subcutaneous SGI-110 Interim Phase 1/2 Data
Phase 1/2 MDS and AML data was presented at AACR 2012 annual meeting in Chicago.
CRO to offer TRAC gene expression analysis for pre-clinical ADME-Tox studies.
Plexpress and SBW Partner to Offer TRAC Gene Expression Analysis
CRO adds TRAC to service portfolio for pre-clinical ADME-Tox studies.
Astex Pharmaceuticals Reports 2012 First Quarter Financial Results
Reports first quarter net income of $4.2 million.
Seward Recruits European Sales Manager for Laboratory Sample Preparation Products
Seward’s European customers and distribution network to benefit from enhanced support.
ELRIG Announces Speaker Programme for Drug Discovery 2012 Conference
The 6th Annual Drug Discovery Conference, in collaboration with SLAS, will be held at Manchester Central Convention Complex on 5th – 6th September 2012.
Luminex Corporation Expands Life Science and Biodefense Groups
Two dedicated groups advance Luminex leadership in scientific research and public safety.
Plexpress Secures $2.3M to Commercialize TRAC High-Content Gene Expression Analysis Platform
Company targets applications including companion diagnostics and ADMET.
Takeda and Metabolon Initiate Research Collaboration
Multiyear research alliance to discover novel targets and biomarkers.
GSK Provides Update on Corporate Responsibility Commitments in 2011 Report
Company publishes its Corporate Responsibility Report, in which it reiterates its commitment to operate responsibly, openly and transparently and sets out advances made on this agenda during 2011.
Astex Pharmaceuticals Announces Subcutaneous SGI-110 Interim Phase 1/2 Data
Phase 1/2 MDS and AML data was presented at AACR 2012 annual meeting in Chicago.
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Classification of Drugs by CNS Access: An Insight from Quantitative Blood-Brain Transport Characteristics
Advanced Chemistry Development
Aim of this study was to identify relationships between quantitative blood-brain transport parameters and qualitative data indicating whether the compound penetrates into the brain efficiently enough to exhibit action in the CNS.
An In Silico Test Battery for Rapid Evaluation of Genotoxic and Carcinogenic Potential of Chemicals
Advanced Chemistry Development Inc
The FDA guidance for industry states impurities under the ICH threshold may be exaluated for genotoxicity and carcinogenicity. This study uses an expert system to detect mutagens and compounds labeled as potent carcinogens by the FDA.
A Systematic Review of Lifestyle Modification in Adults with Non-Alcoholic Fatty Liver Disease
Newcastle University
This study reviews the causes of non-alcoholic fatty liver disease and the associated risk factor for type 2 diabetes and cardiovascular disease.
Cytotoxicity Screen of Mangiferin and its Major Metabolite Norathyriol in Human Tumor Cell Lines
DKFZ
Many natural products are available worldwide as potential chemoprotective agents against commonly occurring cancers, for example Mangiferin which has low bioavailability and is thought to be mainly available in the colon.
Nanoliter Volume Pin Tool Transfers as Measured by a Dual-Dye Absorbance Method
V&P Scientific Inc.
Increasing costs of chemical compounds and commonly used solvents has pushed high throughput screening labs towards lower working volumes, specifically in the nanoliter range. The ability to controllably dispense “known” nanoliter aliquots of samples is desired, which can readily be achieved using Pin Tools.
Why Is My Assay Failing? An Approach to Assay Equipment Optimization
Artel
Assays can produce unexpected or failing results for a multitude of reasons. Variability may be introduced at any point within the assay process.
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments
TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
Modeling Disposition of Sotalol following Intravenous and Oral Administration in Healthy Adult Subjects
Simulations Plus
Sotalol is a non specific adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmia. Its absorption, distribution and systemic PK or, collectively, ‘disposition’ was modeled and simulated using GastroPlus™ v7.0. Biopharmaceutical properties were obtained from in silico predictions and in vitro measurements.
Predicting hERG Potassium Channel Affinity with Artificial Neural Network Ensembles
Simulations Plus
Modeling hERG inhibition has gained significant popularity since 2005, when the FDA recognized the correlation between hERG inhibition and a prolonged QT interval by issuing guidance for the evaluation of new non-antiarrythmic drugs against the hERG channel.Long QT syndrome or LQTS is a risk factor for ventricular tachyarrhythmias and sudden death.
Predicting Sites of Metabolism with Artificial Neural Network Ensembles
Simulations Plus
Hepatic first-pass metabolism of many drugs and pro drugs plays a key role in their oral bioavailability. The human cytochrome P450 enzymes are responsible for the metabolism of most drugs. Knowledge of likely sites of metabolic attack in a drug molecule can aid in designing out unwanted metabolic liabilities early on in the drug discovery process, as well as in the design of pro drugs where metabolic transformation is desired.
Advanced Chemistry Development
Aim of this study was to identify relationships between quantitative blood-brain transport parameters and qualitative data indicating whether the compound penetrates into the brain efficiently enough to exhibit action in the CNS.
An In Silico Test Battery for Rapid Evaluation of Genotoxic and Carcinogenic Potential of Chemicals
Advanced Chemistry Development Inc
The FDA guidance for industry states impurities under the ICH threshold may be exaluated for genotoxicity and carcinogenicity. This study uses an expert system to detect mutagens and compounds labeled as potent carcinogens by the FDA.
A Systematic Review of Lifestyle Modification in Adults with Non-Alcoholic Fatty Liver Disease
Newcastle University
This study reviews the causes of non-alcoholic fatty liver disease and the associated risk factor for type 2 diabetes and cardiovascular disease.
Cytotoxicity Screen of Mangiferin and its Major Metabolite Norathyriol in Human Tumor Cell Lines
DKFZ
Many natural products are available worldwide as potential chemoprotective agents against commonly occurring cancers, for example Mangiferin which has low bioavailability and is thought to be mainly available in the colon.
Nanoliter Volume Pin Tool Transfers as Measured by a Dual-Dye Absorbance Method
V&P Scientific Inc.
Increasing costs of chemical compounds and commonly used solvents has pushed high throughput screening labs towards lower working volumes, specifically in the nanoliter range. The ability to controllably dispense “known” nanoliter aliquots of samples is desired, which can readily be achieved using Pin Tools.
Why Is My Assay Failing? An Approach to Assay Equipment Optimization
Artel
Assays can produce unexpected or failing results for a multitude of reasons. Variability may be introduced at any point within the assay process.
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments
TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
Modeling Disposition of Sotalol following Intravenous and Oral Administration in Healthy Adult Subjects
Simulations Plus
Sotalol is a non specific adrenergic beta-antagonist that is used in the treatment of life-threatening arrhythmia. Its absorption, distribution and systemic PK or, collectively, ‘disposition’ was modeled and simulated using GastroPlus™ v7.0. Biopharmaceutical properties were obtained from in silico predictions and in vitro measurements.
Predicting hERG Potassium Channel Affinity with Artificial Neural Network Ensembles
Simulations Plus
Modeling hERG inhibition has gained significant popularity since 2005, when the FDA recognized the correlation between hERG inhibition and a prolonged QT interval by issuing guidance for the evaluation of new non-antiarrythmic drugs against the hERG channel.Long QT syndrome or LQTS is a risk factor for ventricular tachyarrhythmias and sudden death.
Predicting Sites of Metabolism with Artificial Neural Network Ensembles
Simulations Plus
Hepatic first-pass metabolism of many drugs and pro drugs plays a key role in their oral bioavailability. The human cytochrome P450 enzymes are responsible for the metabolism of most drugs. Knowledge of likely sites of metabolic attack in a drug molecule can aid in designing out unwanted metabolic liabilities early on in the drug discovery process, as well as in the design of pro drugs where metabolic transformation is desired.
BlueScreen HC - A Luminescence Based, High-Throughput, In Vitro Genotoxicity Assay
BMG LABTECH
The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.
A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition
BMG Labtech
Pgp expression has been linked to the effl ux of chemotherapeutic drugs in human cancers leading to multidrug resistance. Pgp activity can also result in low oral absorption and poor brain penetration. Interaction of drugs with the Pgp may also cause an increase in toxicity of co-administered compounds.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific
The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Using a Thermo Scientific Microplate Photometer to Choose an Optimum Reagent for Cytotoxicity Assays
Thermo Fisher Scientific
A number of different reagents can be used to perform photometric cell proliferation and viability assays. A microplate photometer can quickly determine which reagent is the best choice for an assay and then optimize the assay. Significant time savings and productivity gains can be achieved with this tool.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific
The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Antimicrobial Properties of Thermo Scientific Finnpipette F1 Compared to Traditional Pipettes
Thermo Fisher Scientific
In this application note the antimicrobial properties of the Thermo Scientific Finnpipette F1 were compared to traditional pipettes without antimicrobial treatment. The experiments were performed by an independent laboratory (Institut für Biotechnische Forschung und Entwicklung Graf GmbH, Kirkel-Limbach, Germany).
Reproducible Dispensing of Live Cells with the Thermo Scientific Multidrop Combi Reagent Dispenser
Thermo Fisher Scientific
High throughput cell-based assays are an important part of drug screening, and successfully dispensing viable cells is a key step in the process. Automated reagent dispensers are used to achieve higher throughput in the screening laboratories. Dispense must not only be quick, it must also be gentle enough to ensure cell viability.
Device Qualification of the Thermo Scientific Finnpipette Novus Electronic Pipette (IQ/OQ/PQ)
Thermo Fisher Scientific
During device qualification, one verifies and documents whether the equipment, in this case a pipette, is reliable and capable of fulfilling the requirements of its intended use. All qualification activities are fully documented according to pertinent quality and regulatory requirements and signed by authorized personnel.
Use of Thermo Scientific Finnpipette Novus Electronic Pipettes for Accurate and Efficient Preparation of Standard Curves
Thermo Fisher Scientific
This application note discusses the use of a Thermo Scientific Finnpipette Novus Electronic Pipette for the preparation of standard curves. With 10 different functions, the versatile Novus Electronic pipette can perform most every standard curve required. The pipette’s performance was compared to a manual Thermo Scientific Finnpipette model to determine if there were appreciable differences in pipetting speed and accuracy during curve preparation.
MycoAlert Mycoplasma Detection Assay (Lonza) on the SpectraMax® L Microplate Luminometer
Molecular Devices
Mycoplasma infections are costly to the cell culturist as they change the morphology, viability and metabolism of the contaminated cells. Mycoplasmas are the smallest and simplest prokaryotes and depend entirely on their hosts for many nutrients due to their limited biosynthetic capabilities. Cell culture contamination by mycoplasma is difficult to detect as it does not produce pH changes or turbidity, and culture with antibiotics does little to deter this “invisible” menace.
BMG LABTECH
The BlueScreen HC assay from Gentronix utilizes a luminescence-based reporter system to measure genotoxicity. The assay generates positive results e.g for direct-acting mutagens and clastogens and correct negative results for non-carcinogens. In addition, reduced cell proliferation, a measure of cytotoxicity, is assessed, too. Using the FLUOstar Omega microplate reader from BMG LABTECH the BlueScreen HC assay has been shown to be fast, accurate and reproducible.
A Fast and Simple Method For Measuring P-Glycoprotein (Pgp) Inhibition
BMG Labtech
Pgp expression has been linked to the effl ux of chemotherapeutic drugs in human cancers leading to multidrug resistance. Pgp activity can also result in low oral absorption and poor brain penetration. Interaction of drugs with the Pgp may also cause an increase in toxicity of co-administered compounds.
Pipetting performance of Thermo Scientific Finnpipette F2 in combination with Thermo Scientific Finntip Flex
Thermo Fisher Scientific
The Finnpipette® F2 product family has been designed by taking into account the demands of today´s laboratory work and the require¬ments of the end users. It offers superior comfort, performance, reliability and repeatability in one of the lightest pipettes available.
Using a Thermo Scientific Microplate Photometer to Choose an Optimum Reagent for Cytotoxicity Assays
Thermo Fisher Scientific
A number of different reagents can be used to perform photometric cell proliferation and viability assays. A microplate photometer can quickly determine which reagent is the best choice for an assay and then optimize the assay. Significant time savings and productivity gains can be achieved with this tool.
Ergonomics and Usability Study of Thermo Scientific Finnpipette F1 and F2 Pipettes
Thermo Fisher Scientific
The objective of the study was to evaluate the ergonomics and usability of six manual, singlechannel pipettes. This was done by measuring the load and strain symptoms exhibited by workers’ muscles and joints, and evaluating the usability features of pipettes in a simulated work situation.
Antimicrobial Properties of Thermo Scientific Finnpipette F1 Compared to Traditional Pipettes
Thermo Fisher Scientific
In this application note the antimicrobial properties of the Thermo Scientific Finnpipette F1 were compared to traditional pipettes without antimicrobial treatment. The experiments were performed by an independent laboratory (Institut für Biotechnische Forschung und Entwicklung Graf GmbH, Kirkel-Limbach, Germany).
Reproducible Dispensing of Live Cells with the Thermo Scientific Multidrop Combi Reagent Dispenser
Thermo Fisher Scientific
High throughput cell-based assays are an important part of drug screening, and successfully dispensing viable cells is a key step in the process. Automated reagent dispensers are used to achieve higher throughput in the screening laboratories. Dispense must not only be quick, it must also be gentle enough to ensure cell viability.
Device Qualification of the Thermo Scientific Finnpipette Novus Electronic Pipette (IQ/OQ/PQ)
Thermo Fisher Scientific
During device qualification, one verifies and documents whether the equipment, in this case a pipette, is reliable and capable of fulfilling the requirements of its intended use. All qualification activities are fully documented according to pertinent quality and regulatory requirements and signed by authorized personnel.
Use of Thermo Scientific Finnpipette Novus Electronic Pipettes for Accurate and Efficient Preparation of Standard Curves
Thermo Fisher Scientific
This application note discusses the use of a Thermo Scientific Finnpipette Novus Electronic Pipette for the preparation of standard curves. With 10 different functions, the versatile Novus Electronic pipette can perform most every standard curve required. The pipette’s performance was compared to a manual Thermo Scientific Finnpipette model to determine if there were appreciable differences in pipetting speed and accuracy during curve preparation.
MycoAlert Mycoplasma Detection Assay (Lonza) on the SpectraMax® L Microplate Luminometer
Molecular Devices
Mycoplasma infections are costly to the cell culturist as they change the morphology, viability and metabolism of the contaminated cells. Mycoplasmas are the smallest and simplest prokaryotes and depend entirely on their hosts for many nutrients due to their limited biosynthetic capabilities. Cell culture contamination by mycoplasma is difficult to detect as it does not produce pH changes or turbidity, and culture with antibiotics does little to deter this “invisible” menace.
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