Cholinesterases, a Target of Pharmacology and ToxicologyThis review’s main focus is on cholinesterases as targets of toxins and drugs. The biochemistry of AChE and BuChE is also discussed. Drugs and toxins are divided in chapters according to target sites.
Estimation of drug-metabolizing capacity by CYP-genotyping and CYP-expressionThe lack of therapeutic effect of drugs or the appearance of undesired side-effects is partly caused by differences or changes in drug metabolism. This work aims to introduce an approach of combining CYP-genotyping and CYP-phenotyping tools to estimate patients’ drug-metabolizing capacity.
Positive Data on AEOL 11207 in Pre-Clinical Epilepsy ModelAeolus Pharmaceuticals compound significantly decreases both the frequency and duration of spontaneous seizures; increase in average life span; protected against neuronal death.
NanoInk Announces Launch of Contract Services Program for Live Single Cell Assay WorkService offering expected to advance research programs involved with toxicity assessment, high content screening, and cell-cell communication.
Anacor Pharmaceuticals Announces Its Partner GSK Voluntarily Paused Clinical TrialsTrials paused due to a recently identified microbiological finding in a small number of patients in the Phase 2b trial of GSK '052 for the treatment of complicated urinary tract infections (cUTI).
UT Southwestern Research Suggests New Way to Ensure Effectiveness of TB TreatmentBy using a “glass mouse” research model study founds that multidrug-resistant TB is caused in patients by speedy drug metabolism.
Quantum Genomics gets Approval from the Patients' Protection CommitteeThe "Comité de Protection des Personnes (Ile de France VIII)" has approved the first clinical trial in humans of Quantum’s leading compound QGC001; trials are expected to start in early 2012.
The Economist Accused of Inaccurate Coverage of Cell Phone and Wireless RisksSpecialists in public health, oncology, neurosurgery, electronic engineering, toxicology, cardiology and epidemiology have published a critique of an opinion piece published in The Economist (9/3/11), “Worrying about Wireless”.
Companies, Regulatory Authorities Can Spare Millions of Animals in Labs with New OECD Test Method“Two-generation” animal test for reproductive toxicity replaced with a new “extended one-generation” method.
US Tox21 to begin screening 10,000 chemicalsA high-speed robotic screening system, aimed at protecting human health by improving how chemicals are tested in the United States, has begun testing the compounds for potential toxicity.
