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November 2012
Scientific News
Revalesio’s Drug Shows Promise in Treating Alzheimer’s
Multiple published research studies outline the potential for RNS60 to effectively treat Alzheimer’s disease by protecting neuronal function and restoring neuronal plasticity.
Getting Metabolism Right
Analysis of 89 models of metabolic processes finds flaws in 44 of them — but suggests corrections.
Persistent Pharmacokinetic Challenges to Pediatric Drug Development
Current knowledge of rational drug dose adjustments is limited, greater effort needs to be made to determine ontogenic factors that influence ADME.
‘Tissue Chip’ to Screen Neurological Toxins
UW-Madison team are developing a faster, more affordable way to screen for neural toxins.
Promise for Treatment of Pancreatic Cancer
Ultrasound microbubbles can improve tumor absorption of cancer drugs.
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Marijuana Compound May Offer Treatment for AD
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease.
New Advances in the Pre-clinical Evaluation of Hepatitis B Therapies
Imperial College London to present first public HBV Data from CN Bio in vitro liver model.
ADME of Antibody-Maytansinoid Conjugates
Continued understanding of the ADME properties of ADCs entering clinical evaluations should provide additional insight into attributes that may be necessary for clinical success.
Epigenetic Regulation of ADME-Related Genes
The promise of epigenetic research is its potential to identify additional sources of inter individual variability in drug disposition and response.
Cell Based Assays
05 Nov 2012 - 06 Nov 2012
London, UK
Cell Based Assays
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05 Nov 2012 - 07 Nov 2012
Boston, Massachusetts, USA
Simulations Plus Workshop on Computational Tools for Drug Discovery, Lead Optimization and ADMET Property Modeling & Estimation
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12 Nov 2012 - 14 Nov 2012
Johannes Gutenberg-University, Mainz, Germany
Introductory GastroPlus™ Simulation & Modeling Workshop for Drug Absorption, Pharmacokinetics and Pharmacodynamics
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27 Nov 2012 - 29 Nov 2012
Boston. USA
2nd Mitigation Strategies for Reactive Metabolites
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28 Nov 2012 - 29 Nov 2012
Frankfurt, Germany
World PK/PD Summit
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