Following the launch of the manual assay systems for permeability and solubility, Tecan AG and pION INC have developed automated solutions for drug permeability and solubility screening.
The new automated application provides scalability from an upgradeable, entry-level manual system, to a fully automated system with medium or high throughput, according to changing requirements.
pION’s Double-Sink™ parallel artificial membrane permeability assay (PAMPA), a compound-sparing technique that helps to identify the most promising leads well in advance of cell-based methods, has been integrated with Tecan’s Freedom EVO® platform and Infinite® M200 plate reader in the PAMPA Evolution™.
The system offers enhanced walkaway time and high throughput for fully automated processing of permeability assays, while automated miniaturized shake-flask solubility assays can be done with the similarly configured µSOL Evolution™.
The flexibility of the Freedom EVO workstation also allows the same instrument to perform both permeability and solubility assays in a combined set-up, as well as other ADME assays.
The advanced Quad4 Monochromators™ technology in the Infinite M200 provides sensitivity and an optional MultiChannel Arm™ 96 in the Freedom EVO platform increases throughput with sample transfers.