Corporate Banner
Satellite Banner
ADME Tox
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Customized Pharmacokinetics Studies with Knockout Rat Models

Published: Tuesday, July 03, 2012
Last Updated: Monday, July 02, 2012
Bookmark and Share
SAGE™ knockout rats used to investigate the Blood Brain Barrier.

NoAb BioDiscoveries, in collaboration with SAGE Labs, is introducing the use of SAGE™ knockout rats with its tools to investigate the Blood Brain Barrier including micro dialysis and serial CSF collection, as a service to drug discovery researchers.

Rats provided by SAGE (Sigma Advanced Genetic Engineering) Labs are available with knockouts of the specific drug transporter genes Mdr1a, Mrp1, Mrp2, Bcrp, or Oct1.

These advanced animal models are designed to study and characterize the drug-like properties of compounds in vivo.

Dan Lichtman, President and CEO of NoAb BioDiscoveries, said “This partnership with SAGE Labs strengthens our service offering in drug discovery research. Preclinical researchers will benefit from the combined expertise and leadership of NoAb and SAGE.”

NoAb BioDiscoveries is a preclinical Contract Research Organization that offers a wide range ADME-PK Discovery services, specializing in in vivo models, in vitro assays and bioanalytical support.

In addition to standard drug disposition studies, specific surgical catheterization points available at NoAb BioDiscoveries include Jugular Vein, Carotid Artery, Hepatoportal Vein, Bile Duct, and Intestinal Subsections.

Such customized models form an important component of the tools that an investigator can use to address unique and specific questions about their compounds.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 4,000+ scientific posters on ePosters
  • More than 5,300+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

NoAb BioDiscoveries and VigiCell Enter into a Collaboration and Co-Distribution Agreement
The companies have signed an agreement in principle to collaborate and co-distribute each other’s complementary drug discovery services.
Thursday, August 19, 2010
Scientific News
Unique Visual Stimulation May Be New Treatment for Alzheimer’s
Noninvasive technique reduces beta amyloid plaques in mouse models of Alzheimer’s disease.
Genetics Control Regenerative Properties Of Stem Cells
Researchers define how genetic factors control regenerative properties of blood-forming stem cells.
Gene-Editing Improves Vision in Blind Rats
Scientists developed a targeted gene-replacement technique that can modify genes in both dividing and non-dividing cells in living animals.
Uncovering Cerebral Malaria’s Deadly Agents
NIH scientists film inside mouse brains to uncover biology behind the disease.
Blood-brain Barrier on a Chip
Researchers from Vanderbilt University have developed a microfluidic device to study the blood-brain barrier.
Immune-Cell Traps May Aid Cancer Metastasis
Study suggests cancer cells can induce neutrophils to release traps which the cells use to capture pathogens.
Inspiring Futuristic Innovation: Brain ‘Organoids’
Scientists create artificial brains, providing an advanced model for studying brain tumour development.
Parkinson's Disease Linked to Microbiome
Scientists have discovered a link between intestinal bacteria and Parkinson's disease.
Making Personalized Medicine a Reality
Groundbreaking technique developed at McMaster University is helping to pave the way for advances in personalized medicine.
Top 10 Life Science Innovations of 2016
2016 has seen the release of some truly innovative products. To help you digest these developments, The Scientist have listed their top picks for the year.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
4,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,300+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!