Corporate Banner
Satellite Banner
ADME Tox
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

NIH-Funded Tissue Chips would Predict Drug Safety

Published: Friday, August 31, 2012
Last Updated: Friday, August 31, 2012
Bookmark and Share
Researchers from Cornell University will develop microphysiological modules to model the nervous, circulatory and gastrointestinal tract systems.

Cornell's Michael Shuler  has received National Institutes of Health (NIH) funding to make 3-D chips with living cells and tissues that model the structure and function of human organs and help predict drug safety.

Shuler, the James and Marsha McCormick Chair of the Department of Biomedical Engineering, and James Hickman of the University of Central Florida (UCF) jointly received one of 17 NIH grants for tissue chip projects.

Shuler and Hickman's grant of approximately $9 million over five years includes subcontracts to UCF, RegenMed, GE, Sanford-Burnham and Walter Reed Army Institute. It will support their work in microphysiological systems with functional readouts for drug candidate analysis during preclinical testing.

The researchers also plan to build a 10-organ system designed to be low-cost yet highly functional to use in drug discovery, toxicity and preclinical studies.

With the funds, the NIH is supporting bio-engineered devices that will be functionally relevant and will accurately reflect the complexity of a particular tissue, including genomic diversity, disease complexity and pharmacological response.

The NIH tissue chip projects will be tested with compounds known to be safe or toxic in humans to help identify the most reliable drug safety signals -- ultimately advancing research to help predict the safety of drugs in a faster, more cost-effective way.

The initiative marks the first interagency collaboration, with the Defense Advanced Research Projects Agency, launched by the NIH's recently created National Center for Advancing Translational Sciences. The NIH plans to commit up to $70 million over five years to the program.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,600+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Proteins Seek, Attack, Destroy Tumor Cells in Bloodstream
Using white blood cells to ferry potent cancer-killing proteins through the bloodstream virtually eliminates metastatic prostate cancer in mice, Cornell researchers have confirmed.
Friday, January 15, 2016
Three-Photon Microscopy Improves Biological Imaging
Scientists may be a step closer to cracking one of the world's most compelling mysteries: the impossible complexity of the brain and its billions of neurons.
Tuesday, January 22, 2013
Scientific News
Rates of Nonmedical Prescription Opioid Use Disorder Double in 10 Years
Researchers at NIH have found that the nonmedical use of prescription opioids has more than doubled among adults in the United States from 2001-2002 to 2012-2013.
Self-Assembling Protein Shell for Drug Delivery
Made-to-order nano-cages open possibilities of shipping cargo into living cells or fashioning small chemical reactors.
Guided Chemotherapy Missiles
Latching chemotherapy drugs onto proteins that seek out tumors could provide a new way of treating tumors in the brain or with limited blood supply that are hard to reach with traditional chemotherapy.
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
‘Human-on-a-Chip’ Could Replace Animal Testing
Researchers are developing a “human-on-a-chip,” a miniature external replication of the human body, integrating biology and engineering with a combination of microfluidics and multi-electrode arrays.
A New Approach to Chemical Synthesis
Communesins, originally found in fungus, could hold potential as cancer drugs.
‘Missing Tooth’ Hydrogels Handle Hard-to-Deliver Drugs
Rice University’s custom hydrogel traps water-avoiding molecules for slow delivery.
Copper is Key in Burning Fat
Berkeley Lab scientist says results could provide new target for obesity research.
Better Animal Model to Improve HIV Vaccine Development
Penn study identifies a new tool to produce better HIV vaccine designs.
Identifying Side-Effects At Early Stages Of Drug Development
An approach that could reduce the chances of drugs failing during the later stages of clinical trials has been demonstrated by a collaboration between the University of Cambridge and pharmaceutical company GlaxoSmithKline (GSK).
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,600+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!