Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Innovation May Mean Collaborations for Drug Development in Future

Published: Wednesday, September 26, 2012
Last Updated: Wednesday, September 26, 2012
Bookmark and Share
Research collaborations and shared data will mark a change in the fiercely competitive pharmaceutical world, states a new report by healthcare experts GBI Research.

The new report states that academics, industry giants, regulators and patients’ organizations must work together in collaborative research projects in order for modern medicine to flourish.

Over the past decade, the number of New Drug Applications (NDAs) and Biologics License Applications (BLAs) approved by the US Food and Drug Administration (FDA) has fallen steadily, despite ever-increasing R&D expenditure. This gap between investment and success has led the pharmaceutical industry to rethink its business strategies, with industry professionals now working together in order to explore improved pathways for drug discovery and development.

Collaboration and open innovation through Public-Private Partnerships (PPPs) enables research that would not be possible for companies to undertake individually. The consortia tackle precompetitive research – fields of activity in which large companies agree to collaborate and invest in jointly, despite their rivalry in the drug market. Most companies agree that disease biology is a precompetitive science, but that once disease targets are identified, research becomes competitive. These projects aim to eliminate duplication of research, which would waste funding and resources, and also develop competition for samples and clinical trial participation within a single patient population.

The Alzheimer’s Disease Neuroimaging Initiative (ADNI) is a huge PPP, funded by the National Institutes of Health as well as private contributions from pharmaceutical partners through the Foundations for National Institutes of Health. Alzheimer’s disease is difficult to target, as it can progress for many years before symptoms become evident. The path of disease progression is unclear, and clinical trials for any new drug have to be very lengthy, and the failure of a drug to demonstrate efficacy represents both a huge loss of investments for pharma companies, and an ongoing lack of treatment options for patients.

The initiative has produced results which have fundamentally challenged the way in which clinical trials in Alzheimer’s disease should be conducted. Previously, the length of time over which the disease can progress without symptoms was not fully appreciated, and it has become clear that anti-amyloid treatments under investigation may prove far more effective in patients with the disease at an earlier stage than those currently included in clinical trials.

The ADNI represents one of the earliest large PPPs of its type, and stakeholders worked together to decide how to manage data and intellectual property. The decision to place all data into the public domain ensured there were no intellectual property issues, and opened the newly discovered research up to the world. Though is it still uncertain how commercial companies will deal with public access to their research, increased data leveraging undoubtedly makes more sense in the eyes of a scientist or patient.

The ADNI PPP has created a sense of shared responsibility in understanding Alzheimer’s disease and has improved the landscape for clinical research in the future. This could represent a major change to the way in which pharmaceuticals are researched and value created, setting the stage for future collaborations.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,600+ scientific posters on ePosters
  • More than 3,800+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Struggling Pharma Companies to Outsource Clinical Trial Research
Falling revenue in some healthcare sectors means companies are making huge efforts to reduce R&D expenditure and increase profitability.
Monday, April 23, 2012
Scientific News
Developing a Gel that Mimics Human Breast for Cancer Research
Scientists at the Universities of Manchester and Nottingham have been funded to develop a gel that will match many of the biological structures of human breast tissue, to advance cancer research and reduce animal testing.
Lung Repair and Regeneration Gene Discovered
New role for hedgehog gene offers better understanding of lung disease.
New Gene Therapy for Vision Loss From a Mitochondrial Disease
NIH-funded study shows success in targeting mitochondrial DNA in mice.
Self-Propelled Powder to Stop Bleeding
UBC researchers have created the first self-propelled particles capable of delivering coagulants against the flow of blood to treat severe bleeding, a potentially huge advancement in trauma care.
Tension Helps Heart Cells Develop Normally in the Lab
Stanford engineers have uncovered the important role tension plays in growing heart cells out of the body.
Controlling Body Temperature in Response to 'Fight or Flight'
New research in The FASEB Journal suggests that blocking TRPV1 protein causes an increased release of noradrenaline, leading to an increase in core body temperatures.
Inroads Against Leukaemia
Potential for halting disease in molecule isolated from sea sponges.
Researchers Disguise Drugs As Platelets to Target Cancer
Researchers have for the first time developed a technique that coats anticancer drugs in membranes made from a patient’s own platelets.
A Fundamental Protection Mechanism Against Formalin In Mammals is Revealed
Formaldehyde, or formalin, is well known to all of us as a common chemical used in many industrial processes and also as a preservative, remarkably we also produce formaldehyde in our bodies.
Drug Used To Treat HIV Linked to Lower Bone Mass in Newborns
NIH study finds mothers’ use of tenofovir tied to lower bone mineral content in babies.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,600+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,800+ scientific videos