Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Dendrimer Pharmacokinetics: The Effect of Size, Structure and Surface Characteristics on ADME Properties

Published: Thursday, October 04, 2012
Last Updated: Thursday, October 04, 2012
Bookmark and Share
This article explores the relationship between dendrimer structure and systemic disposition, and looks at the challenges of nonparental administration.

Dendrimers show increasing promise as drug-delivery vectors and can be generated with a wide range of scaffold structures, sizes and surface functionalities. To this point, the majority of studies of dendrimer-based drug-delivery systems have detailed pharmacodynamic outcomes, or have followed the pharmacokinetics of a solubilized or conjugated drug. By contrast, detailed commentary on the in vivo fate of the dendrimer carrier is less evident, even though the pharmacokinetics of the carrier will likely dictate both pharmacodynamic and toxicokinetic outcomes. In the current article, the influence of size, structure and surface functionality on the absorption, distribution, metabolism and elimination (ADME) properties of dendrimers have been examined and the implications of these findings for delivery system design are discussed.

This article was published online in the journal Nanomedicine and is free to access.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Proteomics for Systems Toxicology
MS-based proteomics is maturing into a robust technology for the measurement of proteome-wide exposure effects.
Monday, November 24, 2014
Persistent Pharmacokinetic Challenges to Pediatric Drug Development
Current knowledge of rational drug dose adjustments is limited, greater effort needs to be made to determine ontogenic factors that influence ADME.
Wednesday, October 08, 2014
ADME of Antibody-Maytansinoid Conjugates
Continued understanding of the ADME properties of ADCs entering clinical evaluations should provide additional insight into attributes that may be necessary for clinical success.
Wednesday, August 20, 2014
Epigenetic Regulation of ADME-Related Genes
The promise of epigenetic research is its potential to identify additional sources of inter individual variability in drug disposition and response.
Monday, August 04, 2014
Development and Validation of LC/MS/MS Method and its Application to a Pharmacokinetic Study
Researchers aimed to develop a LC/MS/MS method to monitor plasma levels of montelukast, gliclazide, and nifedipine for application in pharmacokinetic studies and routine clinical practice.
Monday, March 17, 2014
Gathering and Exploring Scientific Knowledge in Pharmacovigilance
The holistic assessment of widespread electronic medical records empowers valuable insights over adverse drug events.
Monday, February 24, 2014
Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance
Significant advances have been made in the development of plant-based hepatoprotective drugs mostly because of their lower toxicity.
Tuesday, December 03, 2013
Recent Advances in 2D and 3D in vitro Systems
The possibilities and limitations of the most useful liver in vitro systems are summarized, including 3D culture techniques, co-cultures with non-parenchymal cells.
Sunday, October 06, 2013
Epigenetic Regulation of ADME-Related Genes: Focus on Drug Metabolism and Transport
As research in epigenetic regulation of ADME genes progresses, there are many opportunities and challenges in understanding the epigenetic mechanisms in drug metabolism and disposition.
Monday, September 23, 2013
A Toxicokinetic Model for Thiamethoxam in Rats: Implications for Higher-Tier Risk Assessment
Toxicokinetic models are promising for wildlife risk assessments, but good understanding of feeding patterns is needed for accurate estimation of chronic risk.
Monday, June 17, 2013
Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine
We present a case of a young female patient taking atomoxetine irregularly whose urine drug screen returned as a false-positive amphetamine result that was not confirmed.
Thursday, February 28, 2013
In-solution Hybrid Capture of Bisulfite-converted DNA for Targeted Bisulfite Sequencing of 174 ADME Genes
The aim of this study was to develop a method for the analysis of DNA methylation patterns in 174 ADME genes.
Monday, February 11, 2013
Alcohol ADME in Primates Studied with Positron Emission Tomography
This study aimed to use C-11 labeled alcohol, and C-11 and deuterium dual labeled alcohol, as a pair of PET tracers to study alcohol ADME in the baboon including its metabolism within the various organs.
Monday, January 28, 2013
Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction
Scientists have developed chimeric mice, in which mouse liver is replaced by transplanted human liver cells or tissue-engineered human liver.
Friday, November 16, 2012
FAF-Drugs2: FREE ADME/TOX FILTERING TOOL to Assist Drug Discovery and Chemical Biology Projects
Researchers have developed FAF-Drugs2 to facilitate compound collection preparation, prior to (or after) experimental screening or virtual screening computations.
Thursday, September 27, 2012
Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
Personalized Drug Screening for Multiple Myeloma Patients
A personalized method for testing the effectiveness of drugs that treat multiple myeloma may predict quickly and more accurately the best treatments for individual patients with the bone marrow cancer.
Nanocarriers May Carry New Hope for Brain Cancer Therapy
Berkeley lab researchers develop nanoparticles that can carry therapeutics across the brain blood barrier.
Cancer-Fighting Tomato Component Traced
The metabolic pathway associated with lycopene, the bioactive red pigment found in tomatoes, has been traced by researchers at the University of Illinois.
Batten Disease may Benefit from Gene Therapy
NIH-funded animal study suggests one-shot approach to injecting genes.
Shedding Light on “Dark” Cellular Receptors
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.
Molecule Proves Key to Brain Repair After Stroke
Scientists found that a molecule known as growth and differentiation factor 10 (GDF10) plays a key role in repair mechanisms following stroke.
Towards Patient-Specific Drug Screening
A new breakthrough by the 3D stem cell printing team at Heriot-Watt could pave the way to individually tailored drug testing regimes, both reducing the need for animal testing and ensuring that patients receive drugs which are most effective for their individual needs.
Antibody Targets Key Cancer Marker
University of Wisconsin-Madison researchers have created a molecular structure that attaches to a molecule on highly aggressive brain cancer and causes tumors to light up in a scanning machine.
Gut Bacteria Can Dramatically Amplify Cancer Immunotherapy
Manipulating microbes maximizes tumor immunity in mice.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos