Corporate Banner
Satellite Banner
ADME Tox
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine

Published: Thursday, February 28, 2013
Last Updated: Thursday, February 28, 2013
Bookmark and Share
We present a case of a young female patient taking atomoxetine irregularly whose urine drug screen returned as a false-positive amphetamine result that was not confirmed.

Abstract

The aim of this paper is to report the first case of atomoxetine leading to false-positive urine drug screen. An otherwise healthy 27-year-old female with a history of attention deficit hyperactivity disorder (ADHD) treated with atomoxetine had an acute onset tonic-clonic seizure. On arrival to the hospital, a urine toxicological drug screen with immunochemical cloned enzyme donor immunoassay (CEDIA) was performed. Results were positive for amphetamines; however, the presence of these substances could not be confirmed with urine gas chromatography-mass spectrometry (GC-MS). She denied any illicit drug use, herbal medications, or supplements, and her other prescription medications have not been previously known to cause a false-positive result for amphetamines. While stimulant treatments for ADHD could certainly result in a positive result on urine screen for amphetamines, there have been no reports of false-positive results for amphetamines secondary to patients using atomoxetine. We implicate atomoxetine, and/or its metabolites, as a compound or compounds which may interfere with urine drug immunoassays leading to false-positive results for amphetamines CEDIA assays.

This article was published online in Case Reports in Psychiatry and is free to access.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 4,900+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Proteomics for Systems Toxicology
MS-based proteomics is maturing into a robust technology for the measurement of proteome-wide exposure effects.
Monday, November 24, 2014
Persistent Pharmacokinetic Challenges to Pediatric Drug Development
Current knowledge of rational drug dose adjustments is limited, greater effort needs to be made to determine ontogenic factors that influence ADME.
Wednesday, October 08, 2014
ADME of Antibody-Maytansinoid Conjugates
Continued understanding of the ADME properties of ADCs entering clinical evaluations should provide additional insight into attributes that may be necessary for clinical success.
Wednesday, August 20, 2014
Epigenetic Regulation of ADME-Related Genes
The promise of epigenetic research is its potential to identify additional sources of inter individual variability in drug disposition and response.
Monday, August 04, 2014
Development and Validation of LC/MS/MS Method and its Application to a Pharmacokinetic Study
Researchers aimed to develop a LC/MS/MS method to monitor plasma levels of montelukast, gliclazide, and nifedipine for application in pharmacokinetic studies and routine clinical practice.
Monday, March 17, 2014
Gathering and Exploring Scientific Knowledge in Pharmacovigilance
The holistic assessment of widespread electronic medical records empowers valuable insights over adverse drug events.
Monday, February 24, 2014
Efficient Hepatic Delivery of Drugs: Novel Strategies and Their Significance
Significant advances have been made in the development of plant-based hepatoprotective drugs mostly because of their lower toxicity.
Tuesday, December 03, 2013
Recent Advances in 2D and 3D in vitro Systems
The possibilities and limitations of the most useful liver in vitro systems are summarized, including 3D culture techniques, co-cultures with non-parenchymal cells.
Sunday, October 06, 2013
Epigenetic Regulation of ADME-Related Genes: Focus on Drug Metabolism and Transport
As research in epigenetic regulation of ADME genes progresses, there are many opportunities and challenges in understanding the epigenetic mechanisms in drug metabolism and disposition.
Monday, September 23, 2013
A Toxicokinetic Model for Thiamethoxam in Rats: Implications for Higher-Tier Risk Assessment
Toxicokinetic models are promising for wildlife risk assessments, but good understanding of feeding patterns is needed for accurate estimation of chronic risk.
Monday, June 17, 2013
In-solution Hybrid Capture of Bisulfite-converted DNA for Targeted Bisulfite Sequencing of 174 ADME Genes
The aim of this study was to develop a method for the analysis of DNA methylation patterns in 174 ADME genes.
Monday, February 11, 2013
Alcohol ADME in Primates Studied with Positron Emission Tomography
This study aimed to use C-11 labeled alcohol, and C-11 and deuterium dual labeled alcohol, as a pair of PET tracers to study alcohol ADME in the baboon including its metabolism within the various organs.
Monday, January 28, 2013
Using Chimeric Mice with Humanized Livers to Predict Human Drug Metabolism and a Drug-Drug Interaction
Scientists have developed chimeric mice, in which mouse liver is replaced by transplanted human liver cells or tissue-engineered human liver.
Friday, November 16, 2012
Dendrimer Pharmacokinetics: The Effect of Size, Structure and Surface Characteristics on ADME Properties
This article explores the relationship between dendrimer structure and systemic disposition, and looks at the challenges of nonparental administration.
Thursday, October 04, 2012
FAF-Drugs2: FREE ADME/TOX FILTERING TOOL to Assist Drug Discovery and Chemical Biology Projects
Researchers have developed FAF-Drugs2 to facilitate compound collection preparation, prior to (or after) experimental screening or virtual screening computations.
Thursday, September 27, 2012
Scientific News
Breakthrough Flu Vaccine Inhibited by Pre-existing Antibodies
Universal truths – how existing antibodies are sabotaging the most promising new human flu vaccines.
Gene Therapy for Metabolic Liver Diseases
Researchers have tested gene therapy in pigs from hereditary tyrosinemia type 1, with corrected liver cells being transplanted into the diseased liver.
Zika Vaccine Candidates Show Promise
Two experimental vaccines have shown promise against a major viral strain responsible for the Brazilian Zika outbreak.
Testing Nanoparticle Drug Delivery in Dogs
Scientists have tested a nanoparticle drug delivery against bone cancer in dogs with promising results.
Targeting Autoimmunity
Researchers have developed a strategy to treat a rare autoimmune disease which could lead to treatments of other autoimmune diseases.
Colon Cancer Blocked in Mice
Case Western Reserve University Researchers block common type of colon cancer tumour in mice, laying groundwork for human clinical trial.
Protein Nanocages Could Improve Drug Design and Delivery
HHMI scientists have designed and built 10 large protein icosahedra that are similar to viral capsids that carry viral DNA.
Development in Preventing Macular Degeneration
Following macular degeneration insight, promising drugs to prevent vision loss have been identified.
Improving Tumour Therapy with Nanoparticles
UHN nanoparticle called PEARLs is a promising utilisation of photo-thermal therapy for cancer treatment.
New Antidepressant Treatment Discovered
Scientists have demonstrated how gene therapy could lead to new treatments for depression.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,900+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!