Corporate Banner
Satellite Banner
ADME Tox
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Computer Models More Accurate than Animal Trials

Published: Tuesday, May 21, 2013
Last Updated: Tuesday, May 21, 2013
Bookmark and Share
Expert systems estimate drug uptake in humans (bioavailability) more precisely than animal experiments.

In drug discovery today new drugs are tested on animals, such as rats, dogs and monkeys, to determine whether they are effective and possess sufficient oral bioavailability in these animals.

Up to now, it has been unclear whether animal studies are transferable to humans.

A detailed analysis of the bioavailability knowledge base PACT-F (Preclinical And Clinical Trials Knowledge Base on Bioavailability) from PharmaInformatic, Germany was conducted in order to compare experimental results from animal studies and from human clinical trials. The evaluation was based on more than a hundred approved and marketed drugs.

The research, carried out by PharmaInformatic, has shown that oral bioavailability in animals is inconsistent with the values reported for humans. For many drugs large differences in oral bioavailability were found between humans and animals.

Based on PACT-F, computational models were developed to predict oral bioavailability. The final expert system, called IMPACT-F, calculates human oral bioavailability much more precisely compared to animal trials.

The expert system is a highly reliable way of forecasting oral bioavailability of new drugs. Bioavailability predictions of IMPACT-F were as accurate as the common deviation between individual humans taking part in the same clinical trial.

'It has taken years to develop reliable models, since an excessive amount of clinical data had to be integrated and compared.' says Dr Wolfgang Boomgaarden, founder and CEO of PharmaInformatic. 'Now we have proof that they are significantly more efficient and reliable than animal trials and we hope they will replace useless animal trials soon.'

Every year, millions of animal experiments are carried out. Alternative methods are needed to reduce animal testing. Computational models such as IMPACT-F can replace animal trials. They require no experimental effort, are less expensive and results are almost immediately available. Since they are significantly more reliable than animal models, they will increase the prospects of successful clinical trials in humans.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,000+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Friday, September 12, 2014
Scientific News
The Rise of 3D Cell Culture and in vitro Model Systems for Drug Discovery and Toxicology
An overview of the current technology and the challenges and benefits over 2D cell culture models plus some of the latest advances relating to human health research.
Breakthrough Approach to Breast Cancer Treatment
Scripps scientists have designed a drug candidate that decreases growth of breast cancer cells.
Non-Toxic Approach to Treating Variety of Cancers
A team of researchers at Sylvester Comprehensive Cancer Center at the University of Miami Miller School of Medicine recently discovered a novel, non-toxic approach to treating a wide variety of cancers.
Making Injectable Medicine Safer
Researchers remove excess additives from drugs, which could reduce the odds of serious allergic reactions and other side effects.
An Old-New Weapon Against Emerging Chikungunya Virus
Researchers utilize existing drugs to interfere with host factors required for replication of Chikungunya virus.
Brazilian Zika Virus Strain Causes Birth Defects in Experimental Models
First direct experimental proof of causal effect, researchers say.
'Kidney on a Chip' Facilitates Safer Drug Dosing
University of Michigan researchers have used a "kidney on a chip" device to mimic the flow of medication through human kidneys and measure its effect on kidney cells.
Ketamine Metabolism Lifts Depression
NIH-funded team finds rapid-acting, non-addicting agent in mouse study.
Turning Skin Cells into Heart, Brain Cells
In a major breakthrough, scientists at the Gladstone Institutes transformed skin cells into heart cells and brain cells using a combination of chemicals.
Growing Stem Cells More Safely
Nurturing stem cells atop a bed of mouse cells works well, but is a non-starter for transplants to patients – Brown University scientists are developing a synthetic bed instead.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,000+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!