Corporate Banner
Satellite Banner
ADME Tox
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Plexpress Launches Dedicated Canine ADME-Tox Service

Published: Friday, July 05, 2013
Last Updated: Friday, July 05, 2013
Bookmark and Share
TRACPACK DOG INDUCTION for preclinical drug candidate screening.

Plexpress has launched a specific ADME-Tox service for canine preclinical drug candidate screening, in collaboration with Admescope.

The new TRACPACK DOG INDUCTION screening service provides canine cytochrome P450 (CYP) mRNA analysis using primary dog hepatocytes followed by CYP enzyme activity measurements.

Hepatocytes from three separate donors are used, generating CYP mRNA expression and protein activity data produced in line with the FDA recommendations for human hepatocytes.

Reliable canine-specific CYP analysis is important in order to improve predictions for human pharmaceutical development.

The validated Dog ADME-Tox mRNA panel from Plexpress includes all relevant CYP targets and reference genes, ready-to-analyze in a single well for high throughput multiplexing.

Additional genes can also be included according to study needs.

The combination of high sample throughput with gene multiplexing increases assay speed while minimizing technical variation, making TRAC highly cost- and time-efficient, boosting efficiency in CRO and Pharma laboratories.

In addition to mRNA analysis, TRACKPACK DOG INDUCTION also offers subsequent CYP activity measurements thanks to Plexpress’ collaboration with Admescope.

To investigate metabolites, study compounds are exposed for 72h, after which substrates for CYP-specific model reactions are added, and the samples analyzed.

TRACPACK DOG INDUCTION provides a single, integrated service for all canine CYP induction analysis, ensuring consistent and reliable data.

All TRACPACK results are delivered electronically, in an easy-to-use, summarized report for quick and easy data analysis.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,900+ scientific posters on ePosters
  • More than 4,200+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Plexpress Announces ADME-Tox Programs for CRO’s
EMA and FDA recommend mRNA testing in ADME-Tox studies for superior sensitivity.
Friday, May 03, 2013
Plexpress and Admescope Expand TRACPACK ADME-Tox Screening Services
Efficient, accurate drug discovery that works alongside FDA recommendations.
Monday, November 05, 2012
Plexpress Announces Collaboration with Admescope
CRO to offer TRAC gene expression analysis for pre-clinical ADME-Tox studies.
Thursday, May 17, 2012
Plexpress and SBW Partner to Offer TRAC Gene Expression Analysis
CRO adds TRAC to service portfolio for pre-clinical ADME-Tox studies.
Tuesday, May 08, 2012
Plexpress Secures $2.3M to Commercialize TRAC High-Content Gene Expression Analysis Platform
Company targets applications including companion diagnostics and ADMET.
Thursday, April 19, 2012
Scientific News
Advancing Synthetic Biology
Living systems rely on a dizzying variety of chemical reactions essential to development and survival. Most of these involve a specialized class of protein molecules — the enzymes.
Insights into the Function of the Main Class of Drug Targets
About thirty percent of all medical drugs such as beta-blockers or antidepressants interact with certain types of cell surface proteins called G protein coupled receptors.
Honey’s Potential to Save Lives
The healing powers of honey have been known for thousands of years.
Muscles on-a-Chip
This study may help explain why stem cell-based therapies have so far shown limited benefits for heart attack patients in clinical trials.
3-D Printed Lifelike Liver Tissue for Drug Screening
A team led by engineers at the University of California, San Diego has 3D-printed a tissue that closely mimics the human liver's sophisticated structure and function. The new model could be used for patient-specific drug screening and disease modeling.
Envigo Rat Models Proven to be Susceptible to Intra-Vaginal HSV-2 Infection and Protectable
Scientific findings establish the effectiveness of new approach to investigate the protective effects of vaccine candidates and anti-viral microbodies and to study asymptomatic primary genital HSV-2 infection.
Valvena, GSK Sign New R&D Collaboration
Valneva to supply process development services for EB66® -based Influenza vaccines.
Food Triggers Creation of Regulatory T Cells
IBS researchers document how normal diet establishes immune tolerance conditions in the small intestine.
Counting Cancer-busting Oxygen Molecules
Researchers from the Centre for Nanoscale BioPhotonics (CNBP), an Australian Research Centre of Excellence, have shown that nanoparticles used in combination with X-rays, are a viable method for killing cancer cells deep within the living body.
Crowdfunding the Fight Against Cancer
From budding social causes to groundbreaking businesses to the next big band, crowdfunding has helped connect countless worthy projects with like-minded people willing to support their efforts, even in small ways. But could crowdfunding help fight cancer?
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,900+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,200+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!