Corporate Banner
Satellite Banner
Scientific Community
Become a Member | Sign in
Home>News>This Article

Neuroptis Biotech Announces the Preclinical Results for its Dry Eye Product ML7

Published: Wednesday, November 13, 2013
Last Updated: Wednesday, November 13, 2013
Bookmark and Share
Human clinical trials are planned for mid 2014.

Neuroptis Biotech has announced positive results in preclinical trials of the eye-drop formulation of its ML7 product. ML7 is intended for use in the treatment of eye surface diseases, particularly dry eye.

The candidate molecule, ML7, is the first in a new therapeutic class. It has the potential to bring an effective, targeted therapeutic response to the millions of people who suffer from dry eye syndromes.

This can affect patients' lachrymal apparatus, manifesting as insufficient quality or quantity of tears and a feeling of dry eyes.

The syndrome may be idiopathic, or it may be associated with allergies, inflammation of the anterior segment or Gougerot-Sjogren syndrome. It may also occur following cataract surgery.

Studies in animals have shown excellent local tolerance of the product, very low systemic absorption (less than one per cent) and superior efficacy to the placebo, which uses the same eye drops, but without the ML7.

In the preclinical trials ML7 was used in the form of preservative-free, stable eye drops in single-unit doses.

The preclinical results were published in the medical journal IOVS (Investigative Ophthalmology and Visual Science):

"The completion of preclinical work and studies marks the culmination of efforts by the team at Neuroptis Biotech and their partners, Provence Technologies, Octalia, Cerep and Iris Pharma," said Dr Eric Belot, CEO of Neuroptis Biotech. "We will start phases I and II in the next few months, as soon as the EMA has given its approval for trials on human subjects.”

Treatment for dry eye syndromes is a growth market with an estimated value of USD 1.2 billion worldwide. The company will begin production of clinical batches to launch the clinical trials through a subcontractor.

They will also submit the requisite applications for approval by the European Medicines Agency (EMA) and local patient protection committees.

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Scientific News
High Throughput Mass Spectrometry-Based Screening Assay Trends
Dr John Comley provides an insight into HT MS-based screening with a focus on future user requirements and preferences.
Non-Disease Proteins Kill Brain Cells
Scientists at the forefront of cutting-edge research into neurodegenerative diseases such as Alzheimer’s and Parkinson’s have shown that the mere presence of protein aggregates may be as important as their form and identity in inducing cell death in brain tissue.
Potential Treatment for Life-Threatening Viral Infections Revealed
The findings point to new therapies for Dengue, West Nile and Ebola.
Gut Microbes Signal to the Brain When They're Full
Don't have room for dessert? The bacteria in your gut may be telling you something.
Personalized Drug Screening for Multiple Myeloma Patients
A personalized method for testing the effectiveness of drugs that treat multiple myeloma may predict quickly and more accurately the best treatments for individual patients with the bone marrow cancer.
Nanocarriers May Carry New Hope for Brain Cancer Therapy
Berkeley lab researchers develop nanoparticles that can carry therapeutics across the brain blood barrier.
Cancer-Fighting Tomato Component Traced
The metabolic pathway associated with lycopene, the bioactive red pigment found in tomatoes, has been traced by researchers at the University of Illinois.
Batten Disease may Benefit from Gene Therapy
NIH-funded animal study suggests one-shot approach to injecting genes.
Shedding Light on “Dark” Cellular Receptors
UNC and UCSF labs create a new research tool to find homes for two orphan cell-surface receptors, a crucial step toward finding better therapeutics and causes of drug side effects.
Molecule Proves Key to Brain Repair After Stroke
Scientists found that a molecule known as growth and differentiation factor 10 (GDF10) plays a key role in repair mechanisms following stroke.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos