Corporate Banner
Satellite Banner
ADME Tox
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Curie-Cancer and Meiogenix Sign Two Partnership Agreements

Published: Tuesday, November 19, 2013
Last Updated: Tuesday, November 19, 2013
Bookmark and Share
Curie-Cancer and Meiogenix will develop the SpiX technology in yeast and in mice to unlock unexplored genetic diversity.

Curie-Cancer announces two three-year partnership agreements with Meiogenix. Meiogenix develops SpiX technology under license from Institut Curie and Institut National de la Recherche Agronomique (INRA).

This technology will be deployed in yeast and mice to exploit the unexplored natural biodiversity of organisms.

The process of homologous recombination enables the exchange of nucleotide sequences between two similar or identical DNA strands. It occurs naturally in every cell. In somatic cells, it is mostly involved in the repair of genotoxic lesions, while in germline cells, it is involved in the exchange of genetic material between the parental chromosomes, with the outcome that the traits of a descendant are a ‘mixture’ of traits from its parents. 

Meiotic recombination occurs at numerous places along the chromosome, generating the genetic diversity transmitted by the gametes, but not everywhere and not at the same rate. Some chromosomal regions frequently recombine, but others are ‘cold’, resulting in the fact that they remain in parental configuration in the vast majority of gametes for many generations.

Alain Nicolas, CNRS Research Director at Institut Curie and his team developed this technology to target and enhance meiotic recombination in cold regions. The technology is based on Spo11, an evolutionary conserved endonuclease that naturally catalyzes the formation of meiotic double-strand breaks. SpiX(R) technology is based on the use of Spo11. It modulates the process of homologous recombination in the genome by increasing its frequency in cold regions. By stimulating the process in ‘regions of rare exchange’, SpiX can unlock unexplored genetic diversity.

"Our goals are twofold. Firstly, to investigate the possibilities offered by SpiX in an animal model, in this case mice. A validation in mice could lead to other possible applications in close species such as rats, which are  widely used animal models for studying many diseases such as cancer for example,” said Alain Nicolas “The other objective is to investigate a second generation of the technology and new techniques to control meiotic recombination in yeast, an organism in which we have extensively validated the technology.”

“As an SME, it is not always easy to access academic expertise,” said Giacomo Bastianelli, CEO of Meiogenix. “However, in Curie-Cancer we have found a partner who understands our need to develop the technology and to create industrial value from day one. We anticipate that the results of all our on-going research programs will be of enormous interest in major industrial fields, ranging from agrobiotech, biofuels, industrial yeasts, or animal breeding.”

“These agreements may ultimately help with the treatment of cancer, but they are also touching on other subject areas such as agriculture. This is why we are delighted to be able to contribute to the development of a French SME like Meiogenix,” said Damien Salauze, director of Curie-Cancer. “This partnership embodies the principles of the Institut Carnot label which we were awarded by the French government in 2011 in recognition of our drive to provide genuine solutions for industry and ultimately for patients.”

New perspectives in plants and agronomy
The original focus in the development of the technology was to treat cancer. However, Meiogenix also identified major applications for plants or for  yeast which have been widely used in food production processes for bread, cheese, wine and beer. SpiX technology can be used to target meiotic recombination in specific cold regions of genomes by fusing Spo11 to highly specific binding domains (ZFNs, TALENs). This can help breeders to unlock the genetic diversity that is hard to obtain with current techniques or that will require long breeding cycles.

The current research programs at Meiogenix aim to demonstrate that SpiX is able to increase the frequency of meiotic recombination in cold regions of plant genomes (rice, corn, wheat, etc), resulting in new commercial varieties of plants with interesting traits (resistance to dryness for example). This may have  the potential to meet the food needs of the growing worldwide population.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Novel Technique for Kidney Research Developed
To better understand how the treatment leads to kidney damage, and possibly prevent it, a team of researchers at Yale School of Medicine developed a new 3D-imaging technique to peer deep into these vital organs.
Microscopic Fish are 3D-Printed to do More Than Swim
Researchers demonstrate a novel method to build microscopic robots with complex shapes and functionalities.
Promising Class of New Cancer Drugs Cause Memory Loss in Mice
New findings from The Rockefeller University suggest that the original version of BET inhibitors causes molecular changes in mouse neurons, and can lead to memory loss in mice that receive it.
A Better Way to Personalize Bladder Cancer Treatments
Researchers at UC Davis, in collaboration with colleagues at Jackson Laboratory, have developed a new way to personalize treatments for aggressive bladder cancer.
Breath of Fresh Air for Asthmatics
Researchers hope to develop a platform that will allow a range of drugs to be delivered by inhalation.
Capturing Cell Growth in 3-D
Spinout’s microfluidics device better models how cancer and other cells interact in the body.
Elastic Patch Releases Drugs in a Stretch
Researchers from have developed a drug delivery technology that consists of an elastic patch that can be applied to the skin and will release drugs whenever the patch is stretched.
New Extra ‘Sticky’ Microgel Could Revolutionise Bladder Cancer Treatment
Researchers have designed a new super-efficient way of delivering an anti-cancer drug which could extend and improve the quality of life for bladder cancer patients - and perhaps save lives.
Liposomes: A Basis for Drugs of the Future
An international group of scientists have recently presented a review of liposomes, microscopic capsules widely used all over the world in the development of new drugs.
Common Medications Could Delay Brain Injury Recovery
Drugs used to treat common complaints could delay the recovery of brain injury patients according to research by University of East Anglia (UEA) and University of Aberdeen scientists, published today in Brain Injury.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!