Absorption, Tolerability and Safety Study for Novel Antibacterial Compound Completed Friday, October 19, 2012 Ferrer announced it has successfully completed a clinical trial, in adult and juvenile patients with impetigo, involving Ozenoxacin formulated as a topical treatment. Charles River Laboratories Enters Strategic Partnership with AstraZeneca Friday, October 19, 2012 Global CRO partners with global biopharmaceutical company to accelerate drug development. SAGE® Labs, Ekam Imaging, Inc. Partner on Preclinical Imaging Assays Friday, October 19, 2012 Companies to develop a suite of preclinical services based on the advanced translational power of genetically engineered rat models from SAGE Labs and Ekam's expertise in functional magnetic resonance imaging (fMRI) technology. Synthetic Liver Enzyme Could Result in More Effective Drugs with Fewer Side Effects Tuesday, October 16, 2012 Medicines could be made to have fewer side effects and work in smaller doses with the help of a new technique that makes drug molecules more resistant to breakdown by the human liver. Tissue of Origin Determines Cancer-associated CpG Island Promoter Hypermethylation Patterns Friday, October 05, 2012 Meehan, Sproul and co-workers conclude that general aberrant promoter hypermethylation in cancer does not promote tumorigenesis, but instead reinforces transcription repression inherited from pre-cancerous tissue. Non-Genotoxic Carcinogen Exposure Induces Defined Changes in the 5-Hydroxymethylome Friday, October 05, 2012 In a genome wide study Meehan, Moggs and MARCAR co-authors examined 5mC and 5hmC profiles of liver in control and phenobarbital treated mice. They observe dynamic and reciprocal changes in the 5mC/5hmC patterns over genes promoters that are transcriptionally up-regulated. New Study Says Nanoparticles Don’t Penetrate the Skin Thursday, October 04, 2012 Research by scientists at the University of Bath is challenging claims that nanoparticles in medicated and cosmetic creams are able to transport and deliver active ingredients deep inside the skin. Dendrimer Pharmacokinetics: The Effect of Size, Structure and Surface Characteristics on ADME Properties Thursday, October 04, 2012 This article explores the relationship between dendrimer structure and systemic disposition, and looks at the challenges of nonparental administration. Gentronix Signs First Japanese Contracted Screening Collaboration with Kowa Thursday, October 04, 2012 Gentronix Ltd. has announced the company's first contracted screening project in Japan, with a major Japanese pharmaceutical manufacturer, Kowa Company, Ltd.
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