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Pharmacokinetics, Metabolism and Toxicity of Carbon Nanotubes for Biomedical Purposes
This study reviews the updated data of CNTs from the biomedical view with focus on the pharmacokinetics, metabolism and toxicity of CNTs in vivo. Fall in Deaths Following Withdrawal of Pain Killer Reduction in deaths after withdrawn of pain-relief drug co-proxamol in UK. Urinary Excretion of Platinum, Arsenic and Selenium of Cancer Patients Treated with Platinum-Based Drugs Arsenic exposure increases the risk of non-cancerous and cancerous diseases. This study characterised the short-term urinary excretion amounts of arsenic, selenium and platinum in 24-h urine samples from patients with lung cancer and those with other types of cancer. Urinary Excretion of Platinum, Arsenic and Selenium of Cancer Patients Treated with Platinum-Based Drugs Arsenic exposure increases the risk of non-cancerous and cancerous diseases. This study characterised the short-term urinary excretion amounts of arsenic, selenium and platinum in 24-h urine samples from patients with lung cancer and those with other types of cancer. Inroads to Predict in Vivo Toxicology—An Introduction to the eTOX Project The main barrier for a new drug to enter into clinical development is the preclinical evaluation of toxicity. This project aims to be a database consisting of preclinical toxicity data for drug compounds or candidates extracted from, previously unpublished, legacy reports. Real-Time Visualization and Quantitation of Vascular Permeability In Vivo: Implications for Drug Delivery This paper presents an integrated method to visualize and quantify the real-time dynamics of dextrans in a shell-less chick chorioallantoic (CAM) model. Preclinical Predictors of Anticancer Drug Efficacy: Critical Assessment with Emphasis on Nanomolar Potency This article looks at prediction of cancer drug efficacy in its ultimate user, the human patient and reviews current knowledge followed by illustrative examples that, in the absence of definitive data, provide an empirical perspective. Direct Drug Metabolism Monitoring in a Live Single Hepatic Cell by Video Mass Spectrometry This study of live single-cell level drug metabolism analysis opens the possibility of speedy, low-cost and site-specific monitoring of drug metabolism and a useful tool for single-cell tailored medicine using biopsied cells. Evaluation of Drug Administration Errors in a Teaching Hospital The evaluation and improvement of drug administration process are key elements in patient safety. Researchers directly observed the frequency, type, potential clinical significance and determinants of drug administration errors detected in adult in-patients, with the aim to overcome methodological limitations. Global Patterns of Genetic Diversity and Signals of Natural Selection for Human ADME Genes This study is the first to systematically investigate worldwide population differentiation and potential signals of natural selection in a comprehensive list of ADME genes. 
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