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Highly Efficient Activated Carbon From Palm Shell as an Adsorbent of Toxin/Poison
M.M. Rahman, B. S. Mohsina, K.M. Sharif, B. Y. Kamaruzzaman, M. B. Awang

Highly efficient activated carbon as an adsorbent of toxins has been successfully produced from palm shell through chemical activation process using phosphoric acid as activating agents.

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Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies
Dos Santos G, Mergaert A and Clarke E.

This study aimed to assess if the CFC assay could also be useful at predicting the increased toxicity of drug combinations relative to the toxicity caused by the relevant single agent.

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Digital Dispensing for Direct Dilution: New Flexibility in Dose-Response Analyses
Jeff Nielsen, Ken Ward, Christie Dudenhoefer, David Ochs, Joshua Yu, and Kevin

In addition to the economic advantages of improving speed, precision, compound usage and waste, digital dispensing offers scientific advantages. This includes making the execution of complicated experiments easy and fast.

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Novel Antimalarial Drug Candidates Generated In Silico by Analysis of Public HTS Data
Robert Fraczkiewicz, Michael S. Lawless, Robert D. Clark, and Walter S. Woltosz

This research aims to provide proof-in-principle that in silico tools could be applied to public data so as to efficiently identify active chemistry with good ADMET properties.

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Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops
S. Ray Chaudhuri, V. Lukacova, W.S. Woltosz

A serious disadvantage of ocular timolol therapy is the amount of drug getting into systemic circulation that adversely affects vital organ functions in elderly patients.

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Physiologically-based pharmacokinetic (PBPK) model for prediction of midazolam pharmacokinetics after intranasal administration in children
Viera Lukacova,Siladitya Ray Chaudhuri, Walter S. Woltosz , Michael B. Bolger

Study predicts midazolam absorption and pharmacokinetics (PK) after intranasal (i.n.) administration in young children.

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Physiologically-based pharmacokinetic (PBPK) models for prediction of saquinavir effect on midazolam pharmacodynamics
Viera Lukacova, Haiying Zhou, Walter S. Woltosz, Michael B. Bolger

Purpose: To predict the drug-drug interaction effect of saquinavir on midazolam pharmacodynamics (PD).

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Transporter-based In Vitro-In Vivo Extrapolation (IVIVE)
Viera Lukacova, Michael B. Bolger, Walter S. Woltosz, Neil J. Parrott, Agnès Poirier and T. Lavè

Mechanistic analysis of in vitro measurements to obtain values of kinetic parameters for drug interactions with transporters, as well as for passive diffusion through cell membranes.

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Classification of Drugs by CNS Access: An Insight from Quantitative Blood-Brain Transport Characteristics
Kiril Lanevskij, Pranas Japertas and Remigijus Didziapetris, Advanced Chemistry Development Inc.

Aim of this study was to identify relationships between quantitative blood-brain transport parameters and qualitative data indicating whether the compound penetrates into the brain efficiently enough to exhibit action in the CNS.

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An In Silico Test Battery for Rapid Evaluation of Genotoxic and Carcinogenic Potential of Chemicals
Kiril Lanevskij, Liutauras Juska, Justas Dapkunas, Andrius Sazonovas, Pranas Japertas and Remigijus Didziapetris, of ACD/Labs and Vilnius University

The FDA guidance for industry states impurities under the ICH threshold may be exaluated for genotoxicity and carcinogenicity. This study uses an expert system to detect mutagens and compounds labeled as potent carcinogens by the FDA.

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Showing Results 1 - 10 of 99
Scientific News
Molecular Modelling to Help Create Better, Safer Drugs
How our bodies break down the common drugs ibuprofen, diclofenac and warfarin is the subject of a new study from the University of Bristol.
Computer Simulations Reveal the Energy Landscape of Ion Channels
A team of researchers have investigated the opening and closing mechanisms of these channels: for the first time the full energy landscape of such a large protein could be calculated.
Schmidt Fund Awards to Advance Innovations in Drug Therapy and Search for Planets
Two Princeton University research projects have been selected to receive grants from Princeton's Eric and Wendy Schmidt Transformative Technology Fund.
Side Effects to be Discovered more Quickly, Leading to Safer Prescribing
BMJ Learning has teamed up with the MHRA to launch a new, interactive and multimedia learning module on pharmacovigilance.
Researchers Discover New Therapy for Fragile X Chromosome Syndrome
Researchers at the University of the Basque Country (UPV/EHU) and the Achucarro neurosciences centre have discovered a new therapy for the fragile X chromosome syndrome.
Onconova Announces Positive Data of Oral Rigosertib in Advanced Head and Neck Cancer
Oral rigosertib progresses to phase 2 clinical trial in squamous cell head and neck cancers.
Startup Launched from Georgia Tech-Emory University Research Receives $7.9 Million
Clearside Biomedical, Inc. has received $7.9 million in funding to continue drug and technology development for treatment of ocular diseases.
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic Cells
By genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Yale Researchers Trick Bacteria to Deliver a Safer Vaccine
Yale researchers have developed a new trick, using bacteria’s own cellular mistakes to deliver a safe vaccine.
Trackable Drug-Filled Nanoparticles - a Potential Weapon against Cancer
Tiny particles filled with a drug could be a new tool for treating cancer in the future.
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