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Comparison of Three Methods for the Evaluation of Cytokine Storm Risk in Early and Clinical Stage Biopharmaceutical Development
Gary dos Santos and Emer Clarke

Objective: To identify an assay that can accurately predict the risk of CRS and CS associated with investigational biotherapeutics. A comparison of three methods were used: (a) immobilization of test antibody on plastic, (b) co-culture of PBMC's on HUVEC's and (c) pre-culture of PBMC's at high cell density.

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Isolation, Identification, and Determination of Designer Anabolic Steroids Commonly Found in Dietary Supplements
Sarah E. Voelker, M.S.; Travis M. Falconer, Ph.D.; Jonathan J. Litzau; Mary B. Jones; Lisa M. Lorenz

A general analytical approach in identifying emerging steroid-like compounds is presented, including analysis by GC-MS, LC-MS, and/or HPLC-UV. Isolation of unknown compounds was achieved by high performance liquid chromatography with fraction collection. Isolated compounds were characterized by Nuclear Magnetic Resonance spectroscopy and high resolution accurate mass-mass spectrometry to elucidate their structure.

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A Mass Spectrometer for Elemental Analysis based on Fieldable Technologies
Hilary Brown, Jennifer Speer, John Gerling, and Kenyon Evans-Nguyen

Laser ablation and a Microwave Plasma Torch (MPT) were coupled in order to obtain elemental information from solid samples. The MPT was incorporated as a less costly and more portable alternative to the ICP. MPT was also added to help improve the signal from just the laser ablation alone.

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Combining low and high volume liquid handling capabilities for ADME screening
Joby Jenkins, Kevin Moore, Stephen Fowler, Pascal Schenk

In this study we demonstrate the integration of two liquid handlers to extend the volume dispensing range creating low-volume assay-ready plates with high accuracy and precision. This was then successfully applied to a CYP inhibition assay.

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Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model

The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-ß-cyclodextrin (NC/HPßCD) and hydrophobic triacetyl-ß-cyclodextrin (NC/TAßCD), through the body for controlled drug delivery and sustained release have been examined.

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Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS

The aims of this work were to investigate drug stability prior to, during and after blood spot sampling, using procaine, prulofloxacine, esmolol, and acetylsalisylic acid as examples of drug compounds with limited stability and to compare conventional DBS sampling procedure with DBS sampling including heat stabilization.

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Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS
Charlotta Göransson; Karl Sköld; David Zeeberg; Gunnar Hägglund; Eskil Hermansson; Peter Abrahamsson and Martin Ahnoff

The aims of this work were to investigate drug stability prior to, during and after blood spot sampling, using procaine, prulofloxacine, esmolol, and acetylsalisylic acid as examples of drug compounds with limited stability and to compare conventional DBS sampling procedure with DBS sampling including heat stabilization.

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Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model
Sergey Shityakov and Carola Förster.

The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-ß-cyclodextrin (NC/HPßCD) and hydrophobic triacetyl-ß-cyclodextrin (NC/TAßCD), through the body for controlled drug delivery and sustained release have been examined.

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Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles
Syed Kashif Zafar, Syed Tarique Moin and Zaheer-ul-Haq

MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.

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Scientific News
3-D Engineered Bone Marrow Makes Functioning Platelets
Scalable model supports patient-specific treatments, advanced study of blood disorders.
Single-Cell, 42-plexed Protein Analysis Achieved with a New Microchip Technology
A novel microdevice capable of detecting 42 unique immune effector proteins has been developed.
Mini Synthetic Organism Instead Of Test Animals
Using a compact multi-organ chip, and those of three separate microcircuits, researchers can study the regeneration of certain kidney cells.
Novel Organoid Matrix Enables Long-Term Culture of Human Hepatocytes
Organoid growth matrix to enable long-term culture of genome-stable bipotent stem cells from adult human liver.
First Contracting Human Muscle Grown in Laboratory
Researchers at Duke University report the first lab-grown, contracting human muscle, which could revolutionize drug discovery and personalized medicine.
Antriabio Announces Completion Of PK/PD Studies Of AB101
AB101 positioned to be the first once-weekly basal insulin for diabetes patients.
Anti-Diabetic Drug Springs New Hope for Tuberculosis Patients
Drug for treating diabetes can double up as adjunct treatment for tuberculosis.
A Poisonous Cure
Toxic fungi may hold the secrets to tackling deadly diseases.
Antibiotic Resistance Threatens Future of Modern Medicine
Overuse and misuse of antibiotics, one of the key contributors to antimicrobial resistance (AMR).
Bacterial Toxin Targets Discovered
Understanding how bacterial toxins target human cells is set to have major implications for the development of novel drugs.
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