|Determination of Metabolically Unstable Drugs in Blood by Heat-Stabilized DBS and LC-MS/MS|
Charlotta Göransson; Karl Sköld; David Zeeberg; Gunnar Hägglund; Eskil Hermansson; Peter Abrahamsson and Martin Ahnoff
The aims of this work were to investigate drug stability prior to, during and after blood spot sampling, using procaine, prulofloxacine, esmolol, and acetylsalisylic acid as examples of drug compounds with limited stability and to compare conventional DBS sampling procedure with DBS sampling including heat stabilization.
|Pharmacokinetic Delivery and Metabolizing Rate of Nicardipine Incorporated in Hydrophilic and Hydrophobic Cyclodextrins using Two-Compartment Model|
Sergey Shityakov and Carola Förster.
The dispersion routes of cyclodextrin complexes with nicardipine (NC), such as hydrophilic hydroxypropyl-ß-cyclodextrin (NC/HPßCD) and hydrophobic triacetyl-ß-cyclodextrin (NC/TAßCD), through the body for controlled drug delivery and sustained release have been examined.
|Molecular Dynamics Simulation Study of Pulmonary Surfactant Interacting With Nanoparticles|
Syed Kashif Zafar, Syed Tarique Moin and Zaheer-ul-Haq
MD simulation studies using NAMD of lipid bilayers supported on alpha-quartz (nanoparticles) and kaolinite with explicit water molecules will be presented to understand the physiochemical effects of nanoparticles on pulmonary surfactant.
|Highly Efficient Activated Carbon From Palm Shell as an Adsorbent of Toxin/Poison|
M.M. Rahman, B. S. Mohsina, K.M. Sharif, B. Y. Kamaruzzaman, M. B. Awang
Highly efficient activated carbon as an adsorbent of toxins has been successfully produced from palm shell through chemical activation process using phosphoric acid as activating agents.
|Colony Forming Cell (CFC) Assays Predict for Increased Clinical Neutrophenia with Combination Therapies|
Dos Santos G, Mergaert A and Clarke E.
This study aimed to assess if the CFC assay could also be useful at predicting the increased toxicity of drug combinations relative to the toxicity caused by the relevant single agent.
|Digital Dispensing for Direct Dilution: New Flexibility in Dose-Response Analyses|
Jeff Nielsen, Ken Ward, Christie Dudenhoefer, David Ochs, Joshua Yu, and Kevin
In addition to the economic advantages of improving speed, precision, compound usage and waste, digital dispensing offers scientific advantages. This includes making the execution of complicated experiments easy and fast.
|Novel Antimalarial Drug Candidates Generated In Silico by Analysis of Public HTS Data|
Robert Fraczkiewicz, Michael S. Lawless, Robert D. Clark, and Walter S. Woltosz
This research aims to provide proof-in-principle that in silico tools could be applied to public data so as to efficiently identify active chemistry with good ADMET properties.
|Modeling Drug Disposition of Timolol in Ocular Tissues of Rabbit following Topical Eye Drops|
S. Ray Chaudhuri, V. Lukacova, W.S. Woltosz
A serious disadvantage of ocular timolol therapy is the amount of drug getting into systemic circulation that adversely affects vital organ functions in elderly patients.
|Physiologically-based pharmacokinetic (PBPK) model for prediction of midazolam pharmacokinetics after intranasal administration in children|
Viera Lukacova,Siladitya Ray Chaudhuri, Walter S. Woltosz , Michael B. Bolger
Study predicts midazolam absorption and pharmacokinetics (PK) after intranasal (i.n.) administration in young children.