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In silico Identification of Metabolic Soft Spots: Case Study Using ACD/ADME Suite Software

Metabolic stability, determined in liver microsomes, is one of the primary assays used in early drug discovery. A key factor limiting compound half-life is the cytochrome P450 mediated metabolism. High clearance by these enzymes implies a higher and more frequent dosing as well as poses a risk for individual variations in exposure.

Date Posted: 05/05/2011

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