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Drug Discovery

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Determination of Cell Colony Formation in a High Content Screening Assay

Poster

Published: March 13, 2006

Determination of Cell Colony Formation in a High Content Screening Assay content piece image

Abstract

Here, laser scanning microplate cytometry has been used to provide an automated high content readout of the effects of cytostatic agents on colony formation. This approach determines colony number through the application of a spherical volume algorithm. This permits the differentiation of cytostatic effects where the number of colonies and size remains constant and cytotoxic effects where the size and number may be reduced.