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Evaluation of Compound Cytotoxicity using the Opera
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PerkinElmer

In vitro cytotoxicity assays involving tissue specific cell cultures are considered valuable predictors for human drug toxicity, especially as several cytotoxic effects in a variety of relevant pathways can be assessed simultaneously. Here, we describe an image-based study of Tacrine, FCCP and Acetaminophen impact on mitochondrial mass, cell count, membrane permeability and nuclear area in the human hepatocellular carcinoma cell line HepG2, using the Opera High Content Screening system.

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