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Biodegradable and Biocompatible Comb-Like Polymers for Biomedical Applications

In this work biocompatible and biodegradable NPs, with tunable hydrophobicity and biodegradation kinetics, were synthesized using novel Comb-Like Polymers (CLB). These NPs satisfy requirements for biological purpose for intravenous drug delivery in terms of size, between 20 and 300 nm, particle size distribution, biodegradability and biocompatibility. A number of obtained results for imaging (in vitro, ex vivo and in vivo), cell tracking (stem cells), cellular uptake studies, drug loading (antitumorals), toxicity studies, degradation and release studies are reported.

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