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Wednesday, September 17, 2014
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Scientific News
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Marijuana Compound May Offer Treatment for AD
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease.
New Advances in the Pre-clinical Evaluation of Hepatitis B Therapies
Imperial College London to present first public HBV Data from CN Bio in vitro liver model.
ADME of Antibody-Maytansinoid Conjugates
Continued understanding of the ADME properties of ADCs entering clinical evaluations should provide additional insight into attributes that may be necessary for clinical success.
Epigenetic Regulation of ADME-Related Genes
The promise of epigenetic research is its potential to identify additional sources of inter individual variability in drug disposition and response.
NIST Instrument Enables High-speed Chemical Imaging of Tissues
Researchers have demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures."
Finding Could Revolutionize Drug Discovery
A study by researchers at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Researchers Develop ‘Onion’ Vesicles for Drug Delivery
University of Pennsylvania researchers have shown that dendrimer-based vesicles self-assemble with concentric layers of membranes, much like an onion.
Validation of Drug Toxicity Prediction using DiscoveRx Model
BioMAP® Systems was shown to identify important safety aspects of drugs and chemicals more efficiently and accurately than can be achieved by animal testing.
System 'Prints' Precise, Tailored Drug Dosages
The new approach uses a combination of data and mathematics to determine the precise dosage.

Tumour Regression after Intravenous Administration of Novel Tumour-targeted Nanomedicines
Christine Dufes, University of Strathclyde, speaking at Nanomedicine 2014.

Nanomedicines to Improve the Therapeutic Index of Drugs in Modern Drug Design
Marianne Ashford, AstraZeneca, speaking at Nanomedicine 2014.

Using In vitro and In vivo Models to Assess the Local and Systemic Responses to Nanomaterial Exposure
Vicki Stone, Heriot-Watt University, speaking at Nanomedicine 2014.

Improved Oral Delivery of Antiretroviral Drugs Via A Novel Synthesis of Solid Drug Nanoparticle Formulations
Andrew Owen, University of Liverpool, speaking at Nanomedicine 2014.

Biodegradable and Biocompatible Comb-Like Polymers for Biomedical Applications
Davide Moscatelli, Politecnico di Milano, speaking at Nanomedicine 2014.

TagLite® 2 cell assay - the next dimension to discovering new antibody drugs
Sandra Grau-Richards, Senior Scientist/Team Leader Roche-Glycart

Worried about your cell-based assays? Remote monitoring with CNS offers complete peace of mind!
Michael Fejtl, Market Manager, Tecan Austria

Biotransformation: Still a Bottleneck for in Vitro Kinetic and Dynamic Approaches
Sandra Coecke, European Centre for the Validation of Alternative Methods, speaking at ADME & Predictive Toxicology Europe

Streamlining Routine Chromatography Analyses using eWorkflows
Darren Barrington-Light, Product Specialist, Thermo Scientific

Technology Spotlight: microRNA Biomarkers in Biofluids: Challenges and Solutions
Ditte Andreasen, Exiqon, speaking at Genomics Research Europe 2013.

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