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Scientific News
Computer Simulations Reveal the Energy Landscape of Ion Channels
A team of researchers have investigated the opening and closing mechanisms of these channels: for the first time the full energy landscape of such a large protein could be calculated.
Schmidt Fund Awards to Advance Innovations in Drug Therapy and Search for Planets
Two Princeton University research projects have been selected to receive grants from Princeton's Eric and Wendy Schmidt Transformative Technology Fund.
Side Effects to be Discovered more Quickly, Leading to Safer Prescribing
BMJ Learning has teamed up with the MHRA to launch a new, interactive and multimedia learning module on pharmacovigilance.
Researchers Discover New Therapy for Fragile X Chromosome Syndrome
Researchers at the University of the Basque Country (UPV/EHU) and the Achucarro neurosciences centre have discovered a new therapy for the fragile X chromosome syndrome.
Onconova Announces Positive Data of Oral Rigosertib in Advanced Head and Neck Cancer
Oral rigosertib progresses to phase 2 clinical trial in squamous cell head and neck cancers.
Startup Launched from Georgia Tech-Emory University Research Receives $7.9 Million
Clearside Biomedical, Inc. has received $7.9 million in funding to continue drug and technology development for treatment of ocular diseases.
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic Cells
By genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Yale Researchers Trick Bacteria to Deliver a Safer Vaccine
Yale researchers have developed a new trick, using bacteria’s own cellular mistakes to deliver a safe vaccine.
Trackable Drug-Filled Nanoparticles - a Potential Weapon against Cancer
Tiny particles filled with a drug could be a new tool for treating cancer in the future.
Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine
We present a case of a young female patient taking atomoxetine irregularly whose urine drug screen returned as a false-positive amphetamine result that was not confirmed.

Regulation of Cytochrome P450s and Nuclear Receptor by microRNAs and its Toxicological Implications
Tsuyoshi Yokoi, Kanazawa University, speaking at ADME & Predictive Toxicology Europe

New Insights in Cell Cultures Continuous Monitoring by Nano-Bio-Technology for Sensing and Imaging
Sandro Carrara, University of Genoa, speaking at Cell Culture 2012

Contactless Impedance Analysis for Real-Time Cell Monitoring
Tim Cox, Research Director, Institute of Bio-sensing Technology, speaking at Advances in Biodetection and Biosensors 2012.

Defence and Adaptation in Drug-Mediated Liver Toxicity
Christopher Goldring, University of Liverpool, speaking at ADME & Predictive Toxicology Europe 2012

Rationalizing ADME in the Current Regulatory and Business Environment
Robert Guttendorf, Aclairo Pharmaceutical Development Group, speaking at ADME & Predictive Toxicology Europe

Metabolites and Safety, the MIST and ICH-M3 GUIDANCE and their Impact on ADME
Gerhard Gross, Lundbeck Pharma, speaking at ADME & Predictive Toxicology Europe 2012

In Vitro, Ex Vivo and in Models to Develop New Therapies for Renal Diseases
Frederick W. K. Tam, Imperial College London, speaking at ADME & Predictive Toxicology Europe 2012

Biotransformation: Still a Bottleneck for in Vitro Kinetic and Dynamic Approaches
Sandra Coecke, European Centre for the Validation of Alternative Methods, speaking at ADME & Predictive Toxicology Europe

In Silico Toxicology: Where are We at and Where are We Going?
John C. Dearden, Liverpool John Moores University, speaking at ADME & Predictive Toxicology Europe 2012

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