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Scientific News
An Unlikely Use for Diamonds
Tiny diamonds provide new possibilities for accurate measurements of processes inside living cells with potential to improve drug delivery and cancer therapeutics.
Microscopic “Walkers” Find Their Way Across Cell Surfaces
Technology could provide a way to deliver probes or drugs to cell structures without outside guidance.
Revalesio’s Drug Shows Promise in Treating Alzheimer’s
Multiple published research studies outline the potential for RNS60 to effectively treat Alzheimer’s disease by protecting neuronal function and restoring neuronal plasticity.
Getting Metabolism Right
Analysis of 89 models of metabolic processes finds flaws in 44 of them — but suggests corrections.
Persistent Pharmacokinetic Challenges to Pediatric Drug Development
Current knowledge of rational drug dose adjustments is limited, greater effort needs to be made to determine ontogenic factors that influence ADME.
‘Tissue Chip’ to Screen Neurological Toxins
UW-Madison team are developing a faster, more affordable way to screen for neural toxins.
Promise for Treatment of Pancreatic Cancer
Ultrasound microbubbles can improve tumor absorption of cancer drugs.
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Marijuana Compound May Offer Treatment for AD
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease.
New Advances in the Pre-clinical Evaluation of Hepatitis B Therapies
Imperial College London to present first public HBV Data from CN Bio in vitro liver model.

Microfabricated Cell-Culture Platforms to Study Cell Function and Drug Response in Engineered 2D and 3D Microenvironments
Marcus Textor, ETH Zurich, speaking at Single Cell Analysis Europe 2012.

Regulation of Cytochrome P450s and Nuclear Receptor by microRNAs and its Toxicological Implications
Tsuyoshi Yokoi, Kanazawa University, speaking at ADME & Predictive Toxicology Europe

New Insights in Cell Cultures Continuous Monitoring by Nano-Bio-Technology for Sensing and Imaging
Sandro Carrara, University of Genoa, speaking at Cell Culture 2012

Contactless Impedance Analysis for Real-Time Cell Monitoring
Tim Cox, Research Director, Institute of Bio-sensing Technology, speaking at Advances in Biodetection and Biosensors 2012.

Defence and Adaptation in Drug-Mediated Liver Toxicity
Christopher Goldring, University of Liverpool, speaking at ADME & Predictive Toxicology Europe 2012

Rationalizing ADME in the Current Regulatory and Business Environment
Robert Guttendorf, Aclairo Pharmaceutical Development Group, speaking at ADME & Predictive Toxicology Europe

Metabolites and Safety, the MIST and ICH-M3 GUIDANCE and their Impact on ADME
Gerhard Gross, Lundbeck Pharma, speaking at ADME & Predictive Toxicology Europe 2012

In Vitro, Ex Vivo and in Models to Develop New Therapies for Renal Diseases
Frederick W. K. Tam, Imperial College London, speaking at ADME & Predictive Toxicology Europe 2012

Biotransformation: Still a Bottleneck for in Vitro Kinetic and Dynamic Approaches
Sandra Coecke, European Centre for the Validation of Alternative Methods, speaking at ADME & Predictive Toxicology Europe

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