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Scientific News
Getting Metabolism Right
Analysis of 89 models of metabolic processes finds flaws in 44 of them — but suggests corrections.
Persistent Pharmacokinetic Challenges to Pediatric Drug Development
Current knowledge of rational drug dose adjustments is limited, greater effort needs to be made to determine ontogenic factors that influence ADME.
‘Tissue Chip’ to Screen Neurological Toxins
UW-Madison team are developing a faster, more affordable way to screen for neural toxins.
Promise for Treatment of Pancreatic Cancer
Ultrasound microbubbles can improve tumor absorption of cancer drugs.
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Marijuana Compound May Offer Treatment for AD
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease.
New Advances in the Pre-clinical Evaluation of Hepatitis B Therapies
Imperial College London to present first public HBV Data from CN Bio in vitro liver model.
ADME of Antibody-Maytansinoid Conjugates
Continued understanding of the ADME properties of ADCs entering clinical evaluations should provide additional insight into attributes that may be necessary for clinical success.
Epigenetic Regulation of ADME-Related Genes
The promise of epigenetic research is its potential to identify additional sources of inter individual variability in drug disposition and response.
NIST Instrument Enables High-speed Chemical Imaging of Tissues
Researchers have demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures."

Use of Informatics Approaches in Risk Assessments
Sandeep Modi, Cheminformatician, Unilever speaking at ADMET Europe 2011

Drug Metabolism and Toxicity: Influence of Genetic and Epigenetic Factors
Magnus Ingelman-Sundberg, Professor and Head of Pharmacogenetics, Karolinska Institutet speaking at ADMET Europe 2011

Physiologically Based Pharmacokinetic/Pharmacodynamic Modelling for Lead Optimisation of CNS-Active Therapeutics
Simon Thomas, Cyprotex, speaking at Screening Europe 2010

Predicting Hepatotoxicity with CellCiphr HCS technology: Rat and Human Hepatotoxicity Predicton: Validation and Case Studies
Katya Tsaioun, CSO, Cyprotex speaking at ADMET Europe 2011

Metabolomics Platform for Toxicology Research in Zebrafish
Elwin Verheij, TNO, speaking at European Biomarkers Summit 2010.

A Novel Strategy for Bespoke Tissue-Specific Biomarkers for Drug Development
Gary Coulton, Director, University of London, speaking at European Biomarkers Summit 2010.

Dried Blood Spot Samples for ADME, Biomarker Analysis and Metabolomics
Elwin Verheij, Innovation Manager, TNO, speaking at ADMET Europe

Predicting the Kinetics of Drugs in the Brain
Simon Thomas, Head of Scientific Computing, Cyprotex Discovery Ltd, speaking at ADMET Europe

A Project Driven Approach to Efficient Generation of QSAR Models
Adrian Stevens, Lead Scientist, Accelrys, speaking at ADMET Europe

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