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Scientific News
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Marijuana Compound May Offer Treatment for AD
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease.
New Advances in the Pre-clinical Evaluation of Hepatitis B Therapies
Imperial College London to present first public HBV Data from CN Bio in vitro liver model.
ADME of Antibody-Maytansinoid Conjugates
Continued understanding of the ADME properties of ADCs entering clinical evaluations should provide additional insight into attributes that may be necessary for clinical success.
Epigenetic Regulation of ADME-Related Genes
The promise of epigenetic research is its potential to identify additional sources of inter individual variability in drug disposition and response.
NIST Instrument Enables High-speed Chemical Imaging of Tissues
Researchers have demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures."
Finding Could Revolutionize Drug Discovery
A study by researchers at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Researchers Develop ‘Onion’ Vesicles for Drug Delivery
University of Pennsylvania researchers have shown that dendrimer-based vesicles self-assemble with concentric layers of membranes, much like an onion.
Validation of Drug Toxicity Prediction using DiscoveRx Model
BioMAP® Systems was shown to identify important safety aspects of drugs and chemicals more efficiently and accurately than can be achieved by animal testing.
System 'Prints' Precise, Tailored Drug Dosages
The new approach uses a combination of data and mathematics to determine the precise dosage.

Physiologically Based Pharmacokinetic/Pharmacodynamic Modelling for Lead Optimisation of CNS-Active Therapeutics
Simon Thomas, Cyprotex, speaking at Screening Europe 2010

Predicting Hepatotoxicity with CellCiphr HCS technology: Rat and Human Hepatotoxicity Predicton: Validation and Case Studies
Katya Tsaioun, CSO, Cyprotex speaking at ADMET Europe 2011

Metabolomics Platform for Toxicology Research in Zebrafish
Elwin Verheij, TNO, speaking at European Biomarkers Summit 2010.

A Novel Strategy for Bespoke Tissue-Specific Biomarkers for Drug Development
Gary Coulton, Director, University of London, speaking at European Biomarkers Summit 2010.

Dried Blood Spot Samples for ADME, Biomarker Analysis and Metabolomics
Elwin Verheij, Innovation Manager, TNO, speaking at ADMET Europe

Predicting the Kinetics of Drugs in the Brain
Simon Thomas, Head of Scientific Computing, Cyprotex Discovery Ltd, speaking at ADMET Europe

A Project Driven Approach to Efficient Generation of QSAR Models
Adrian Stevens, Lead Scientist, Accelrys, speaking at ADMET Europe

In Silico Methods for ADMET and Solubility Prediction
John Mitchell, Group Leader, University of St-Andrews, speaking at ADMET Europe

Metabonomics – Recent Advances in Multivariate Methods and some Results Relating to Diabetes
Richard Barton, Professor, Imperial College London, speaking at ADMET Europe

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