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Scientific News
Observing Behavior of Single Molecules in Real Time
New technique developed by Stanford scientists allows observation of single molecules of protein or DNA as they bind with other molecules.
Development and Validation of LC/MS/MS Method and its Application to a Pharmacokinetic Study
Researchers aimed to develop a LC/MS/MS method to monitor plasma levels of montelukast, gliclazide, and nifedipine for application in pharmacokinetic studies and routine clinical practice.
Mini-Livers Show Promise to Reduce Animal Use in Science
Using this method, cells from one mouse could be used to test 1000 drug compounds to treat liver disease, and reduce animal use by up to 50,000.
Advancing the Knowledge of Pharmaceutical Processes
Linkam Scientific Instruments report on the use of their stages in the study of pharmaceutical processes.
Gathering and Exploring Scientific Knowledge in Pharmacovigilance
The holistic assessment of widespread electronic medical records empowers valuable insights over adverse drug events.
A Silk Coat for Diamonds Makes Sleek New Imaging and Drug Delivery Tool
New kind of tiny glowing particle could provide a novel technique for biological imaging and drug delivery.
Biases in Animal Studies may Differ from those in Clinical Trials
New analysis of animal studies on cholesterol-lowering statins found that non-industry studies had results that favored the drugs even more than studies funded by industry.
TAP Biosystems Presents New Data on 3D Cell Culture Research
Discussing the application of RAFT 3D models in oncology, toxicology and neuroscience cell-based screening programmes.
Scripps' Scientists Develop Promising Drug Candidates for Pain and Addiction
Two new drug scaffolds offer researchers novel tools that act on the kappa opioid receptor.
World’s Tiniest Drug Cabinets could be Attached to Cancerous Cells for Long Term Treatment
Reservoirs of pharmaceuticals could be manufactured to bind specifically to infected tissue such as cancer cells for slow, concentrated delivery of drug treatments.

Impedance-Based Measurement of GPCR Modulators in Drug Discovery – Characterization of Signalling Pathways in Recombinant and Non-Recombinant Cells
John Gatfield, Senior Lab Head Molecular Biology, Actelion Pharmaceuticals Ltd, speaking at Screening Europe 2009

Advancing Drug Discovery in an Academic Setting
Julie Frearson, Professor Biotechnology/Drug Discovery/Biological Chemistry and Molecular Pharmacology, University of Dundee, speaking at Screening Europe 2009

De Novo Molecular Design: A Powerful Strategy for the Discovery of New Potential Antimalarials and Antibacterials
Colin Fishwick, Reader/ Director Organic Chemistry/Leeds Structure-Based Drug Design Group, University of Leeds School of Chemistry, speaking at MedChem Europe 2009

Intersecting Biological and Chemical Knowledge for Computational Toxicology
Florian Nigsch, Research Associate, University of Cambridge, speaking at ADMET Europe 2009

Bioluminescent Cytochrome P450 Inhibition and Induction Assays: Comparisons to Conventional Methods
Jim Cali, Senior Scientist, Promega, speaking at ADMET Europe 2009

In silico Prediction of ADMET Properties
John Dearden, School of Pharmacy and Chemistry, Liverpool John Moores University, speaking as ADMET Europe 2009

Retigabine and Therapeutic Indications of Activating Neuronal KCNQ Voltage-Gated Potassium Ion Channels
Jim Wu, Head of Discovery Biology, Roche R&D Center, speaking at Ion Channel Targets 2008

Hypertension in P2Y2 Receptor-Deficient Mice is Caused by Constitutive Activation of ENaC
James Stockand, Associate Professor, University of Texas Health Science Center at Houston, speaking at Ion Channel Targets 2008

Mechanosensitivity, A Wide Open Field
Frederick Sachs, Distinguished Professor, New York State University at Buffalo, speaking at Ion Channel Targets 2008

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