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Scientific News
Microscopic “Walkers” Find Their Way Across Cell Surfaces
Technology could provide a way to deliver probes or drugs to cell structures without outside guidance.
Revalesio’s Drug Shows Promise in Treating Alzheimer’s
Multiple published research studies outline the potential for RNS60 to effectively treat Alzheimer’s disease by protecting neuronal function and restoring neuronal plasticity.
Getting Metabolism Right
Analysis of 89 models of metabolic processes finds flaws in 44 of them — but suggests corrections.
Persistent Pharmacokinetic Challenges to Pediatric Drug Development
Current knowledge of rational drug dose adjustments is limited, greater effort needs to be made to determine ontogenic factors that influence ADME.
‘Tissue Chip’ to Screen Neurological Toxins
UW-Madison team are developing a faster, more affordable way to screen for neural toxins.
Promise for Treatment of Pancreatic Cancer
Ultrasound microbubbles can improve tumor absorption of cancer drugs.
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Marijuana Compound May Offer Treatment for AD
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease.
New Advances in the Pre-clinical Evaluation of Hepatitis B Therapies
Imperial College London to present first public HBV Data from CN Bio in vitro liver model.
ADME of Antibody-Maytansinoid Conjugates
Continued understanding of the ADME properties of ADCs entering clinical evaluations should provide additional insight into attributes that may be necessary for clinical success.

Metabonomics – Recent Advances in Multivariate Methods and some Results Relating to Diabetes
Richard Barton, Professor, Imperial College London, speaking at ADMET Europe

Drug-Drug Interactions Involving non-CYP Phase I or Phase II Enzymes can we Predict?
Olivier Barberan, Director of Product Development, Aureus Pharma, speaking at ADMET Europe

Illuminating Your Pathway to Discovery: Cell based Assays For Efficacy and Safety Profiling
Martin Augustin, European Technology Manager, Drug Discovery, Millipore, speaking at Screening Europe 2010

MS Binding Assays - A New Concept for Drug Screening
Klaus Wanner, Full Professor, Ludwig- Maximilians-University Munich, speaking at Screening Europe 2009

Pharmacological Characterization of GPRC6A – A 7TM Receptor Activated by L-a-Amino Acids and Positively Modulated by Divalent Cations
Petrine Wellendorph, Associate Professor, University of Copenhagen, speaking at Screening Europe 2009

Testing Drug-Induced Inhibition of hERG: How Voltage and Inactivation Makes a Difference
Harry Witchel, Senior Lecturer in Physiology, Brighton and Sussex Medical School, University of Sussex, speaking at ADMET Europe 2009

Development of Proteomics Methods for Profiling Cytochrome P450s
Chris Sutton, Head of the ICT Proteomics and Mass Spectrometry Facility, Bradford University, speaking at ADMET Europe 2009

Kinase Inhibitors with Tailored Binding Kinetics by Fragment-Based Design
Peter Sennhenn, Head of Medicinal Chemistry, Proteros fragments GmbH, speaking at MedChem Europe 2009

Impedance-Based Measurement of GPCR Modulators in Drug Discovery – Characterization of Signalling Pathways in Recombinant and Non-Recombinant Cells
John Gatfield, Senior Lab Head Molecular Biology, Actelion Pharmaceuticals Ltd, speaking at Screening Europe 2009

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