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Scientific News
ADME of Antibody-Maytansinoid Conjugates
Continued understanding of the ADME properties of ADCs entering clinical evaluations should provide additional insight into attributes that may be necessary for clinical success.
Epigenetic Regulation of ADME-Related Genes
The promise of epigenetic research is its potential to identify additional sources of inter individual variability in drug disposition and response.
NIST Instrument Enables High-speed Chemical Imaging of Tissues
Researchers have demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures."
Finding Could Revolutionize Drug Discovery
A study by researchers at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Researchers Develop ‘Onion’ Vesicles for Drug Delivery
University of Pennsylvania researchers have shown that dendrimer-based vesicles self-assemble with concentric layers of membranes, much like an onion.
Validation of Drug Toxicity Prediction using DiscoveRx Model
BioMAP® Systems was shown to identify important safety aspects of drugs and chemicals more efficiently and accurately than can be achieved by animal testing.
System 'Prints' Precise, Tailored Drug Dosages
The new approach uses a combination of data and mathematics to determine the precise dosage.
Mice and Rats Stressed by Male Experimenters
An international team of pain researchers led by scientists at McGill University have found that the gender of the experimenters has a big impact on the stress levels of rodents.
Skin Layer Grown in Lab Could Replace Animal Testing
Skin layer grown from human stem cells could replace animals in drug and cosmetics testing.
Observing Behavior of Single Molecules in Real Time
New technique developed by Stanford scientists allows observation of single molecules of protein or DNA as they bind with other molecules.

Illuminating Your Pathway to Discovery: Cell based Assays For Efficacy and Safety Profiling
Martin Augustin, European Technology Manager, Drug Discovery, Millipore, speaking at Screening Europe 2010

MS Binding Assays - A New Concept for Drug Screening
Klaus Wanner, Full Professor, Ludwig- Maximilians-University Munich, speaking at Screening Europe 2009

Pharmacological Characterization of GPRC6A – A 7TM Receptor Activated by L-a-Amino Acids and Positively Modulated by Divalent Cations
Petrine Wellendorph, Associate Professor, University of Copenhagen, speaking at Screening Europe 2009

Testing Drug-Induced Inhibition of hERG: How Voltage and Inactivation Makes a Difference
Harry Witchel, Senior Lecturer in Physiology, Brighton and Sussex Medical School, University of Sussex, speaking at ADMET Europe 2009

Development of Proteomics Methods for Profiling Cytochrome P450s
Chris Sutton, Head of the ICT Proteomics and Mass Spectrometry Facility, Bradford University, speaking at ADMET Europe 2009

Kinase Inhibitors with Tailored Binding Kinetics by Fragment-Based Design
Peter Sennhenn, Head of Medicinal Chemistry, Proteros fragments GmbH, speaking at MedChem Europe 2009

Impedance-Based Measurement of GPCR Modulators in Drug Discovery – Characterization of Signalling Pathways in Recombinant and Non-Recombinant Cells
John Gatfield, Senior Lab Head Molecular Biology, Actelion Pharmaceuticals Ltd, speaking at Screening Europe 2009

Advancing Drug Discovery in an Academic Setting
Julie Frearson, Professor Biotechnology/Drug Discovery/Biological Chemistry and Molecular Pharmacology, University of Dundee, speaking at Screening Europe 2009

De Novo Molecular Design: A Powerful Strategy for the Discovery of New Potential Antimalarials and Antibacterials
Colin Fishwick, Reader/ Director Organic Chemistry/Leeds Structure-Based Drug Design Group, University of Leeds School of Chemistry, speaking at MedChem Europe 2009

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