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Scientific News
Computer Simulations Reveal the Energy Landscape of Ion Channels
A team of researchers have investigated the opening and closing mechanisms of these channels: for the first time the full energy landscape of such a large protein could be calculated.
Schmidt Fund Awards to Advance Innovations in Drug Therapy and Search for Planets
Two Princeton University research projects have been selected to receive grants from Princeton's Eric and Wendy Schmidt Transformative Technology Fund.
Side Effects to be Discovered more Quickly, Leading to Safer Prescribing
BMJ Learning has teamed up with the MHRA to launch a new, interactive and multimedia learning module on pharmacovigilance.
Researchers Discover New Therapy for Fragile X Chromosome Syndrome
Researchers at the University of the Basque Country (UPV/EHU) and the Achucarro neurosciences centre have discovered a new therapy for the fragile X chromosome syndrome.
Onconova Announces Positive Data of Oral Rigosertib in Advanced Head and Neck Cancer
Oral rigosertib progresses to phase 2 clinical trial in squamous cell head and neck cancers.
Startup Launched from Georgia Tech-Emory University Research Receives $7.9 Million
Clearside Biomedical, Inc. has received $7.9 million in funding to continue drug and technology development for treatment of ocular diseases.
Unanticipated Consequences of DNA Hypomethylation; Loss and Gain of Polycomb Mediated Transcription Repression in Somatic Cells
By genome-wide mapping of the Polycomb Repressive Complex 2 (PRC2)-signature histone mark, H3K27me3, in DNA methylation-deficient mouse somatic cells, the Meehan lab shows that loss of DNA methylation is coincident with widespread H3K27me3 redistribution.
Yale Researchers Trick Bacteria to Deliver a Safer Vaccine
Yale researchers have developed a new trick, using bacteria’s own cellular mistakes to deliver a safe vaccine.
Trackable Drug-Filled Nanoparticles - a Potential Weapon against Cancer
Tiny particles filled with a drug could be a new tool for treating cancer in the future.
Amphetamine Positive Urine Toxicology Screen Secondary to Atomoxetine
We present a case of a young female patient taking atomoxetine irregularly whose urine drug screen returned as a false-positive amphetamine result that was not confirmed.

Automated Ion Channel Drug Discovery: Evaluation of hERG Inhibitors
Dr. Timm Danker, Application Specialist, Cytocentrics AG speaking at Screening Europe 2006.

Metabolomics as a Tool for Biomarker Discovery
Dr. Chris Beecher, Vice President of Biochemistry and Technology, Metabolon, Inc., speaking at Advances in Metabolic Profiling 2005

HTS/HCS in the Context of Genetic Toxicology
Dr. Richard Walmsley, University of Manchester and Gentronix Ltd. speaking at Screening Europe 2006.

Metabolic Profiles and Biomarkers for Detection and Prediction of Drug Effects
Hans Senn of F. Hoffmann-La Roche AG speaking at Advances in Metabolic Profiling 2005.

Predicting the Safety of FDA Regulated Products with Metabolomics
Laura Schnackenberg, Center for Metabolomics Research, speaks at Advances in Metabolic Profiling 2005.

HERG, Repolarization and Sudden Cardiac Death
Arthur M. Brown, Chairman and CEO, ChanTest, Inc., speaks at Ion Channel Targets 2005.

Extracellular Field Potential Recording in Cardiac Myocyte Culture with the QT-Screen System
Prof. Dr. Elke Guenther, Head of Electrophysiology, NMI Natural and Medical Sciences Institute, speaking at Screening Europe 2005.

hERG Screening: Ion Channel Cardiac Safety Pharmacology Using Whole-Cell Recordings in FlipTips
Dr. Martin Traebert, Group Head of in vitro Safety Pharmacology in Preclinical Development, Novartis Pharma AG, speaking at Screening Europe 2005.

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