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Scientific News
Animal Testing can Mislead Drug Discovery and Development
Several blockbuster drugs would not be on the market, if scientists had relied solely on drug-uptake in animal trials, according to new research.
Marijuana Compound May Offer Treatment for AD
Extremely low levels of the compound in marijuana known as delta-9-tetrahydrocannabinol, or THC, may slow or halt the progression of Alzheimer’s disease.
New Advances in the Pre-clinical Evaluation of Hepatitis B Therapies
Imperial College London to present first public HBV Data from CN Bio in vitro liver model.
ADME of Antibody-Maytansinoid Conjugates
Continued understanding of the ADME properties of ADCs entering clinical evaluations should provide additional insight into attributes that may be necessary for clinical success.
Epigenetic Regulation of ADME-Related Genes
The promise of epigenetic research is its potential to identify additional sources of inter individual variability in drug disposition and response.
NIST Instrument Enables High-speed Chemical Imaging of Tissues
Researchers have demonstrated a dramatically improved technique for analyzing biological cells and tissues based on characteristic molecular vibration "signatures."
Finding Could Revolutionize Drug Discovery
A study by researchers at IRB Barcelona reveals the existence of information highways that connect and correlate distant sites within a single protein.
Researchers Develop ‘Onion’ Vesicles for Drug Delivery
University of Pennsylvania researchers have shown that dendrimer-based vesicles self-assemble with concentric layers of membranes, much like an onion.
Validation of Drug Toxicity Prediction using DiscoveRx Model
BioMAP® Systems was shown to identify important safety aspects of drugs and chemicals more efficiently and accurately than can be achieved by animal testing.
System 'Prints' Precise, Tailored Drug Dosages
The new approach uses a combination of data and mathematics to determine the precise dosage.

Bioluminescent Cytochrome P450 Inhibition and Induction Assays: Comparisons to Conventional Methods
Jim Cali, Senior Scientist, Promega, speaking at ADMET Europe 2009

In silico Prediction of ADMET Properties
John Dearden, School of Pharmacy and Chemistry, Liverpool John Moores University, speaking as ADMET Europe 2009

Retigabine and Therapeutic Indications of Activating Neuronal KCNQ Voltage-Gated Potassium Ion Channels
Jim Wu, Head of Discovery Biology, Roche R&D Center, speaking at Ion Channel Targets 2008

Hypertension in P2Y2 Receptor-Deficient Mice is Caused by Constitutive Activation of ENaC
James Stockand, Associate Professor, University of Texas Health Science Center at Houston, speaking at Ion Channel Targets 2008

Mechanosensitivity, A Wide Open Field
Frederick Sachs, Distinguished Professor, New York State University at Buffalo, speaking at Ion Channel Targets 2008

Novel Recombinant Peptide Toxin Fusion Proteins as Potential Therapeutics for the Treatment of Autoimmune Disease
Hung Nguyen, Principal Scientist, Amgen, speaking at Ion Channel Targets 2008

Chemogenomics in Drug Discovery
Hugo Kubinyi, Retired Professor, Pharmaceutical Chemistry, University of Heidelberg, speaking at MedChem Europe 2009

Prediction of Drug-Drug Interactions Caused by Metabolism-Based Inhibition of Cytochrome P450 Using a Mechanistic Static Model: The Weak & Missing Links?
Olivier Barberan, Director of Product Development, AUREUS-Pharma, speaking at ADMET Europe 2009

Ion Channel Panels for Safety Assessment and Drug Discovery
Arthur "Buzz" Brown, President & CEO, ChanTest Corporation, speaking at Ion Channel Targets 2008

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