Corporate Banner
Satellite Banner
AgriGenomics
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Life Technologies Announces Patent Protection for TAL Effector Technology

Published: Tuesday, May 14, 2013
Last Updated: Tuesday, May 14, 2013
Bookmark and Share
Patent covers nucleic acids encoding Transcription Activator-Like Effector Nuclease fusion proteins (TALENS) and the formal launch of an associated sublicensing program.

The technology has broad utility in the pharmaceutical industry, synthetic biology, and plant sciences for creating genetically modified cell lines, animals and plants, and is being actively explored for potential uses in human gene therapy.

Life Technologies has exclusive rights to U.S. Patent No. 8,420,782 B2, "Modular DNA-Binding Domains and Methods of Use" issued April 16, a fundamental intellectual property for all applications of TAL effectors in fields outside commercial use in plants. Life  markets TALENS under the brand name GeneArt® Precision TAL Technology. TAL effectors bind to specific DNA sequences with higher precision than zinc finger binding proteins and can be used to deliver a variety of functional elements to activate or repress gene expression or cut and insert DNA.

"The GeneArt® Precision TAL technology is being employed in numerous commercial R&D applications, including identification of new pharmaceutical compounds, disease modeling and bioproduction technology," said Nathan Wood, general manager and vice president of synthetic biology at Life Technologies. "Their ability to bind to DNA with unprecedented precision and reliability makes TAL effectors invaluable to researchers looking to edit genomes and control gene activity."

The current patent names Jens Boch, Ulla Bonas, Thomas Lahaye and Sebastian Schornack as inventors, and is based on work conducted at Martin-Luther-Universitat Halle-Wittenberg. The Two Blades Foundation, a U.S.-based charitable organization, owns exclusive rights to commercial applications in plants and is committed to making TAL technology broadly available through licensing.

"Patent protection brings increased assurance to our industrial customers with regard to bringing new products to market," said Wood, "and for our agriculture customers, through our strong partnership with Two Blades, a path forward in commercializing their R&D efforts."

Among Life Technologies' first sublicensees of TAL technology are ToolGen, Inc., which is using the technology to generate transgenic animal models and cell lines and Cellular Dynamics International, which is applying TAL effectors to introduce or correct disease-associated mutations in induced pluripotent stem cell lines.

GeneArt® Precision TALs are supplied as Gateway® compatible entry clones encoding a DNA binding protein for a specific customer-submitted sequence fused to a range of customer selected effector domains. Custom TALs are typically delivered within two weeks after orders are placed.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Marijuana Genome Unraveled
A study by Canadian researchers is providing a clearer picture of the evolutionary history and genetic organization of cannabis, a step that could have agricultural, medical and legal implications for this valuable crop.
Grape Waste Could Make Competitive Biofuel
The solid waste left over from wine-making could make a competitive biofuel, University of Adelaide researchers have found.
Accelerating Forage Breeding to Boost Livestock Productivity
International expert skill-sets in genomics and bioinformatics enhance our capacity to breed improved forages for Africa.
Firefly Protein Enables Visualization of Roots in Soil
A new imaging tool from a team led by Carnegie’s José Dinneny allows researchers to study the dynamic growth of root systems in soil, and to uncover the molecular signaling pathways that control such growth.
So Long, Snout
Research helps answer how birds got their beaks.
The Tree of Life — More Like A Bush
New species evolve whenever a lineage splits off into several. Because of this, the kinship between species is often described in terms of a ‘tree of life’, where every branch constitutes a species.
Algae Nutrient Recycling is a Triple Win
Sandia method cheaper, greener and cuts competition for fertilizer.
Non-Transgenic Rapeseed Product Launched For Chinese Market
Cibus and Rotam have announced a new agreement to cooperate in the development of herbicide-tolerant rapeseed in China.
TGAC Leads Development to Diminish Threat to Vietnam’s Most Important Crop
Advanced bioinformatics capabilities for next-generation rice genomics in Vietnam to aid precision breeding.
BESC Creates Microbe That Bolsters Isobutanol Production
Another barrier to commercially viable biofuels from sources other than corn has fallen with the engineering of a microbe that improves isobutanol yields by a factor of 10.
Skyscraper Banner

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!