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Amino-Coated Metallofullerene Nanoparticles for Glioblastoma Mutiforme Tumor Detection
Tinghui Li , Susan. Murphy, Kanwarpal Bakshi, Steven LaConte, Zhi Sheng, and Harry Dorn

We report the preparation of a new functionalized trimetallic nitride endohedral metallofullerene, with a cage surface consisting of positively charged amino groups, which is expected to bind more efficiently to negatively charged cell phospholipid bi-layer cellular surfaces and will more readily undergo endocytosis. We now report that this Gd-nanoplatform when subsequently conjugated with an IL-13 peptide, (IL-13-Gd3N@C80(OH)x(NH2)y) exhibits enhanced targeting of U-251 GBM cell lines.

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Design and Evaluation of High Definition Probe for HPV genotyping Microarray
Sihn Ae Lee, Ah Reum Park, Inyoung Kim, Ji Hyung Lee, and Jongwon Kim

To improve the sensitivity and specificity of the HPV DNA Microarray, we adopted triple oligonucleotide probes for each targets and selected these probes not to have higher similarity of 75% with each others. These triple probes have shown 10 ~ 100 times higher sensitivities with comparable specificities than the conventional HPV DNA microarray of single oligonuclotide probe.

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Gut Microbial Metabolites and Hepatic Xenobiotic Metabolism: A High Throughput Screening Approach
Glynn Martin, James Sidaway, Jonathan Swann

This poster highlights the combination of metabonomics and high throughput screening by the identification of gut microbial metabolites and a screening assay designed to determine their cytotoxicity to liver-like cell cultures.

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Digital PCR to Determine the Number of Transcripts from Single Neurons after Patch-clamp Recording
Nóra Faragó1,2, Ágnes K. Kocsis3, Sándor Lovas3, Gábor Molnár3, Márton Rózsa3, Viktor Szemenyei3, Ágnes Zvara2, Gábor Tamás3, László G Puskás1,2

Whole-cell patch-clamp recording enables detecting electrophysiological signals from neurons, and RNA can be harvested into the patch pipette from the cells.We have optimized a dPCR protocol for determining exact transcript numbers in single neurons after patch-clamp recording by using dPCR based on high-density nanocapillary PCR.

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Rapid Quantification of Proteins in Complex Matrices using the DeNovix DS11 Microvolume Spectrophotometer
Mebs A Surve & Dan Schieffer

In this poster, we will introduce the DeNovix DS-11 as the next generation in microvolume spectrophotometry.

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Mixtures Analysis of Complex Mixtures
Michael Bernstein; Carlos Cobas; Santi Domínguez; Manuel Pérez; Agustín Barba

We describe an NMR method to quantify mixture components in wine, edible oils, etc. The method is fully customizable, and amenable to high throughput operation.

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A Complete Wine Analysis Using Multiplets Detection
Dr Michael Bernstein1; Agustín Barba1; Dr Susanne Klein2; Dr Andrea Dreiseitel2; Daniel Heidger2 and Volker Heidger2

NMR mixtures analysis can be used to determine the concentration of key components in wine. Here we show the analysis using SMA from Mestrelab.

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A Novel Approach Toward Microfluidic Drug Metabolite Synthesis – Electrosynthetic Methodology Simulating Cytochrome (CYP450) Oxidation
Romain Stalder, Gregory P. Roth and Philip Podmore

A novel microfluidic technology and electrochemical synthesis method is demonstrated for the efficient generation of known drug metabolites. These metabolites are typically generated on first pass hepatic oxidation in vivo. The FLUX Module, a new microfluidic electrochemical cell manufactured by Syrris Ltd., has been employed to generate the metabolites of five commercial drugs: Tolbutamide, Chlorpromazine, Diclofenac, Primidone and Albendazole.

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A complete workflow from sample preparation to analysis using SureSelect target enrichment system for Ion Proton semiconductor sequencing
Christian Le Cocq, Kyeong Soo Jeong, Arjun Vadapalli, Joseph Ong, Elin Agne, Filip Karlsson, Ashutosh Ashutosh, Francisco Useche, Jayati Ghosh, Henrik Johansson, Scott Happe, Douglas Roberts, and Holly Hogrefe

Agilent’s SureSelect Target Enrichment for the Ion Proton Platform provides a comprehensive, efficient, robust, and cost-effective means to sequence subsets of the human genome.

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Showing Results 41 - 50 of 117
Scientific News
Sweet Potato Is 'Genetically Modified' By Nature
Researchers from Ghent University and the International Potato Institute have discovered that sweet potatoes naturally contain genes from a bacterium. Because of the presence of this 'foreign' DNA, sweet potato can be seen as a 'natural gmo'.
Genetic Code Of Upland Cotton Cracked
Scientists decode the genetic makeup of upland cotton.
Honey Bees Use Multiple Genetic Pathways To Fight Infections
The findings may help scientists develop honey bee treatments that are tailored to specific types of infections.
Detailed Genetic Map of World Wheat Varieties Developed
Kansas State University researchers are releasing a study that details the first haplotype map of wheat.
New Test To Revolutionise Disease Detection In People, Crops And Stock
A single-drop DNA test invented by UQ scientists could revolutionise the detection of diseases in humans, livestock and crops.
Fast-Growing Trees That Are Easier To Turn Into Fuel
Researchers at the University of Georgia have discovered that manipulation of a specific gene in a hardwood tree species not only makes it easier to break down the wood into fuel, but also significantly increases tree growth.
Study Seeks to Reduce Effects of the South’s Most Costly Weed
A new study published in the journal Weed Science.
CT Scanning Shows Why Tilting Trees Produce Better Biofuel
Researchers use X-ray micro-computed tomography to examine the willow's growth through high resolution 3D images.
Pathogen-Sensing ‘Antenna’ Gene Transferred To Wheat
A receptor that recognises bacteria from Arabidopsis thaliana has been transferred to wheat.
Novel Online Bioinformatics Tool Significantly Reduces Time Of Multiple Genome Analysis
UK research collaboration develops a new bioinformatics pipeline that enables automated primer design for multiple genome species, significantly reducing turnaround time.
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