Satellite Banner
Technology Networks Header
Thursday, October 23, 2014
Technology Networks
 
Register | Sign in
Home Page > Videos > Preclinical Drug Safety: High Quality Data obtained with a New Automated Patch Clamp Platform
  Videos

Return

Preclinical Drug Safety: High Quality Data obtained with a New Automated Patch Clamp Platform
Select Biosciences Ltd

Many compounds have been reported to prolong the QT interval interfering with the hERG channel, leading to life-threatening cardiac arrhythmias. According to FDA guideline every drug going to market must be tested on the hERG channel. Due to this international regulation, there is a great demand for accurate hERG screens as well as for other pacemaker channels. Manual patch clamp is still the gold standard for investigation of ion channels, but throughput is low and a skilled operator is needed. Cytocentrics overcomes these problems by developing the CytoPatch™ Instrument. Thus outsourcing of patch clamp screening offers a true advantage to drug developing companies: Lowering their operating costs and having access to the latest technology and scientific expertise. As examples for the patch clamp quality of the CytoPatch™ Instrument we show that the electrophysiological and pharmacological properties of the cardiac potassium channels like hERG and kv1.5 investigated on the CytoPatch™ Instrument are in excellent agreement with data known from manual patch clamp: This demonstrates that ion channel screening on the CytoPatch™ Instrument delivers the same high data quality known from manual patch clamp at a throughput level required for safety pharmacology screening.

Request more information
Company product page



For access to this article, enter your email address to instantly recieve a Password Reset link.

Please enter your email address below:

Existing users please Sign In here. Don't have an account? Register Here for free access.

Don't have an account? | Register Here

Scientific News
New Catalyst could Improve Production of Biofuels
Washington State University researchers have developed a new catalyst that could lead to making biofuels cheaply and more efficiently.
Eureka Genomics and VeriPrime Beef Cooperative Partner
Deal to develop molecular assays to better manage cattle health risk.
Producing Orange Corn Rich in Provitamin A
Improvement of carotenoid levels in corn a simpler, faster process for plant breeders.
Plant Variants Point the Way to Improved Biofuel Production
Manufacturing biofuels from food crop by-products such as straw could be made quicker and cheaper thanks to a new study led by scientists at the University of York.
Improving Korean Wheat
Dae Wook Kim learns genetic screening techniques to develop a line of Korean wheat.
Merck Animal Health to Market Neogen's Dairy Genomic Program
Agreement to market Neogen's Igenity® Dairy Heifer Program.
A Big Step Towards More Efficient Photosynthesis
For the first time flowering plants have been successfully engineered to fix carbon like the blue-green algae do - this can potentially increase photosynthesis and yields in crop plants.
Corn Spots: Study Finds Important Genes in Defense Response
A number of candidate genes have been identified that appear to control the defense response in corn.
Genetic Basis for Rabbit Domestication Revealed
Research presents key findings in the DNA make-up of the common mammal’s brain and nervous system, which determines how wild rabbits were genetically transformed to domestic rabbits.
Scientists Looking Across Human, Fly and Worm Genomes Find Shared Biology
Studies reveal powerful commonalities in biological activity and regulation among species.
Scroll Up
Scroll Down
Skyscraper Banner
Skyscraper Banner
Follow TechNetcom1 on Twitter
Technology Networks Ltd. on LinkedIn
Go to LabTube.tv