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Trace Element Speciation Analysis ...
PerkinElmer chemagic 360...Behind the Science, episode 7: Get Relax...Increase volume throughput from samples ...

Featured Products
Provance® Prepacked Protein A Columns
Provance® Prepacked Protein A Columns
Sartobind STIC® Salt-Tolerant Membrane Chromatography
Sartobind STIC® Salt-Tolerant Membrane Chromatography

Webcasts
How to Optimize Sample Preparation Step Prior to ExtractionHow to Optimize Sample Preparation Step Prior to Extraction
Discover the benefits of bead-binding for sample preparation in this on demand webinar from Bertin Technologies.
A Potentially Scalable Method for the Harvesting of hMSCs from Microcarriers: Initial ResultsA Potentially Scalable Method for the Harvesting of hMSCs from Microcarriers: Initial Results
Qasim Rafiq, Loughbrough University, speaking at Advances in Cellular Assays & Cell Culture 2014

Market Reports
Immunoassay Auto Trends 2014
HTStec

This report comprehensively documents current practices and preferences in immunoassays and to understand future user requirements, particularly with respect to immunoassay automation.
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Pharmaceutical Key Trends 2011: Biosimilar Market Overview
Datamonitor plc

Biosimilars were estimated to have generated approximately $200m in sales during the twelve months to March 2010. Going forward, with branded biologics worth $55bn set to face patent expiry between 2011 and 2015, this presents a major opportunity for companies looking to enter the biosimilars market.
Preclinical Development of Monoclonal Antibodies and Related Biologicals: Emerging technologies and new therapeutic candidates
Business Insights

This report explains what monoclonal antibodies are, and why large pharmaceutical companies are investing so heavily both in developing such drugs internally and acquiring monoclonal antibody candidates from others. More than 80 popular and emerging technologies are named, explained and illustrated with original full-color diagrams.
Innovations in Combating Infectious Diseases: Opportunities in therapeutics and diagnostics through application of proteomics, genomics, nanotechnology, and novel sources of lead generation
Business Insights

This report makes a detailed and comprehensive analysis of the cutting edge of research aiming to reveal how bacteria, viruses, fungi, and prions infect and affect their hosts. It also assesses the new technologies and techniques that are being used to design and develop the anti-infective drugs and diagnostic methods of the 21st century.
Cancer Vaccines & Circulating Tumor Cells (CTCs) 2011 Report
Select Biosciences Ltd

This market report from Select Biosciences presents a comprehensive industry analysis of the cancer vaccines space as well as that of the emerging circulating tumor cells (CTCs) space. These two areas are evolving and expanding driven by the greater emphasis on personalized medicine especially in the cancer/oncology space.
Biosimilars and Biobetters: Positioning for a New Market
Select Biosciences Ltd

As regulatory frameworks for biosimilars development begin to take shape worldwide, there are growing opportunities for generics companies to enter the biologics market, a segment which is uniquely driven by unmet needs, commands premium prices, and continues to outperform the global pharma market.
Novel Antibodies & Therapeutic Proteins: Technological Challenges & Future Prospects
Select Biosciences Ltd

This innovative & analytical report can be used to assess market trends & appraise the potential of new antibodies & therapeutic proteins. It provides perspective to gain an in-depth understanding of the marketplace, players, products & leading technologies driving the field.
Scientific News
Featured Article - ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
ASMS 2016: Targeting Mass Spectrometry Tools for the Masses
The expanding application range of MS in life sciences, food, energy, and health sciences research was highlighted at this year's ASMS meeting in San Antonio, Texas.

Anthrax Proteins Might Help Treat Cancerous Tumors
Studies in mice reveal novel treatment regimen.
HIV Structure Stabilized
Findings represent ‘big accomplishment’ in biomedical engineering and design.
Anthrax Vaccine Protects Monkeys
Vaccination with the anthrax capsule—a naturally occurring component of the bacterium that causes the disease—completely protected monkeys from lethal anthrax infection, according to a recently published study.
Long-Term Culturing of Adult Stem Cells
A new procedure developed by Harvard Stem Cell Institute researchers (HSCI) at Massachusetts General Hospital (MGH) may revolutionize the culturing of adult stem cells.
Solutions for Biotherapeutic Characterization
Innovation to speed the routine.
Plant-Based Vaccine Among Front Runners In Search For New Polio Jab
A researcher from Norwich is part of a consortium that has been awarded $1.5 million to develop safer polio vaccines, using a new technique developed at the John Innes Centre.
Harnessing Helpful Microbes
Seeking to further harness microbes’ many uses, the federal government has launched the National Microbiome Initiative (NMI) to “foster the integrated study of microbiomes across different ecosystems.”
What Makes a Good Scientist?
It’s the journey, not just the destination that counts as a scientist when conducting research.
A New Approach to Chemical Synthesis
Communesins, originally found in fungus, could hold potential as cancer drugs.
Business News
Merck, Moderna Announce Strategic Collaboration
Collaboration combines Merck’s leadership in immuno-oncology with Moderna’s pioneering mrna vaccine technology and rapid cycle time, small-batch GMP manufacturing capabilities.
MilliporeSigma, IVI Announce Collaboration
Collaboration aims to help in the development of more robust, scalable vaccine manufacturing processes.
Inovio, GeneOne Life Science Receive Approval
Company has received approval to initiate a phase I human trial to evaluate Inovio’s Zika DNA vaccine to prevent infection from this concerning virus.
Novartis Adds Two Bispecific Antibodies to its Development Portfolio
Agreement is the latest in a series of acquisitions and strategic collaborations that have bolstered Novartis' deep and diverse immuno-oncology pipeline.
Charles River Acquires Blue Stream
Acquisition combines Blue Stream with Charles River’s existing discovery, safety assessment, and biologics capabilities creates a leading provider with the ability to support biologic and biosimilar development from characterization through clinical testing and commercialization.
Pfizer Advances Biosimilars Leadership with Investment in Biotechnology Center
Company has announced that the facility will foster the continued development of the biotechnology industry in China, further supporting National healthcare reforms.
EpimAb, Innovent Announce Collaboration
Company has announced collaboration with Innovent Biologics for the development of bispecific antibodies.
Cobra Biologics, Alligator Bioscience Announce Partnership
Partnership aims to develop second cell line for manufacture of immuno-oncology antibody ADC-1015 following ADC-1013 success.
Thermo, NIBRT Announce Collaboration
Analytical solutions designed to streamline workflows, quickly generate data for deeper understanding of molecular complexes.
Waters Collaborates with Singapore’s Bioprocessing Technology Institute
Organizations partner to enhance the development of analytical methods and glycan libraries for cancer glycobiology, focusing on glycosphingolipids.

Events
Lyophilisation Europe
04 Jul 2016
Lyophilisation Europe ...
More information
9th China Bioindustry Conventi
05 Jul 2016
9th China Bioindustry Conventi ...
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Extracellular Vesicles 2016
12 Jul 2016
Extracellular Vesicles 2016 ...
More information
Ophthalmic Drug Development Su
26 Jul 2016
Ophthalmic Drug Development Su ...
More information

ePosters
Platform Agnostic Data Processing Routine for Targeted and Untargeted Metabolite Identification in Drug Discovery
1Advanced Chemistry Development, Inc. (ACD/Labs), 8 King Street East, Toronto, ON. M5C 1B5. Canada; 2ACD/Labs, Moscow, Russia

A discussion of a new informatics solution that addresses common challenges in metabolite identification and characterization--from LC/MS data processing and metabolites prediction to reporting and databasing of assembled biotransformation knowledge.
A Novel Set of Serum-Free, Xeno-Free Differentiation Media for Adipogenesis, Osteogenesis and Chondrogenesis of Human Mesenchymal Stem Cells from Various Tissue Sources
Biological Industries

An overview of a novel SF, XF differentiation system which enables achieving defined conditions for rapid generation of differentiated hMSCs towards tissue engineering and drug screening applications.
Molecular Abnormalities in Schizophrenia: Neurotransmission, Oxidative Stress, and Apoptosis
1Section of Biomolecular Medicine, Division of Computational and Systems Medicine, Department of Surgery and Cancer, Faculty of Medicine, Imperial College, London SW7 2AZ, U.K. 2

A multi-platform approach was employed to analyse distinct brain regions implicated in schizophrenia.
Accurate Mass Spectral Database: Harnessing the Power of High Performance Mass Spectrometry at Long Last
LECO Corporation, Moscow State University

Standard mixtures comprising of alkanes, PAHs, semivolatiles, and pesticides were analyzed using a high resolution time-of-flight (HRTOF) mass spectrometer—Pegasus GC-HRT (LECO Corporation, Saint Joseph,MI)—at 10 spectra-per-second (m/z40–300) in high resolution mode (25,000 at FWHH). The resulting chromatographic peaks were automatically found, deconvoluted, and curated into an Accurate Mass Library (AML).
Super-resolution single molecule localization microscopy of the exocytotic machinery underlying insulin secretion.
Heriot-Watt Univeristy

Single molecule imaging of the tSNARE proteins involved in insulin secretion.
Automated Sample Preparation of Whole Blood for Therapeutic Drug Monitoring and Diagnostics by LC-MS using a Commercial Autosampler
1 University of Applied Sciences and Arts Northwestern Switzerland FHNW, Institute for Chemistry and Bioanalytics , Gründenstrasse 40, 4132 Muttenz; 2 CTC Analytics AG; Industriestrasse 20, CH-4222 Zw

In this poster the parameters necessary to automatically prepare whole blood samples for online LC-MS applications in the field of diagnostics and TDM have been investigated. A strategy and the most important parameters are shown for the optimization of a PAL RTC autosampler
for the preparation of whole blood samples.
Development and Application of Quantitative Immunoassays for Major Milk Allergens Bos d 5 (β-lactoglobulin) and Bos d 11 (β-casein)
1. Indoor Biotechnologies, Ltd., Cardiff, Wales, UK. 2. INRA, Gif-sur-Yvette, France

In this study, we sought to develop accurate, sensitive and reliable assays that would enable quantification of multiple milk allergens.

Diagnosing Coral disease with Metabolomic Markers
NYUAD

Application of untargeted metabolomics for the identification of disease markers in corals
Quantitative Cell-Based Bioassays for Individual and Combination Immune Checkpoint Immunotherapy Targets
Promega Corporation

Immune checkpoint receptors are promising new immunotherapy
targets for the treatment of a variety of diseases including cancer and
autoimmune-mediated disorders. We developed a suite of cell-based
bioluminescent reporter bioassays for individual and combination
immune checkpoint immunotherapy targets including: PD-1 (PD-L1 or PD-L2), CTLA-4, LAG-3, TIGIT, PD-1+TIGIT, GITR, 4-1BB, CD40, and OX40.

A Novel Set of Serum-Free, Xeno-Free Differentiation Media for Adipogenesis, Osteogenesis and Chondrogenesis of Human Mesenchymal Stem Cells from Various Tissue Sources
Biological Industries

An overview of a novel SF, XF differentiation system which enables achieving defined conditions for rapid generation of differentiated hMSCs towards tissue engineering and drug screening applications
Application Notes
Accelerating Biotherapeutic Process Development Using Differential Scanning Calorimetry
Malvern Instruments Limited

This document illustrates how the technique can be used to examine the stability of individual domains in multi-domain proteins and guide process development for antibodies and other proteins.
Evaluation of the IntelliQube® for Gene Expression Analysis using a One-Step RT-PCR Workflow
Douglas Scientific

A recent study demonstrates the ability of the IntelliQube® and associated Array Tape®, to process RNA samples using a one-step RT-PCR workflow, opening the door to a variety of RNA screening applications including gene expression or viral detection and quantification.
Contribution of variable domains to the stability of humanized IgG1 monoclonal antibodies
Malvern Instruments Limited

The rapid growth of the therapeutic antibody market has increased the interest in modeling of the antibody structure and in understanding the factors that affect the function and the stability of antibodies.
Identification of Insulin Oligomeric States Using SEC-MALS
Wyatt Technology Corporation

This application note shows how the combination of column chromatography (SEC/GPC) with MALS, DLS and RI detection can be applied as a powerful tool to identify monomers, dimers, hexamers and higher aggregates of insulin.
Charge and Interaction Analysis for Predicting Antibody Formulation Stability
Wyatt Technology Corporation

Colloidal stability is a key solution property of a biotherapeutic formulations, indicative of long-term stability. As it is readily measured over much shorter time scales than long-term stability testing or even accelerated testing regimens, measurements of colloidal stability are often utilized in the course of formulation work to screen out poorly behaved conditions.
The Diffusion Interaction Parameter (kD) as an Indicator of Colloidal and Thermal Stability
Wyatt Technology Corporation

This experiment demonstrates that thermal and colloidal stability of proteins, two indicators of propensity to aggregate, as well as actual aggregation states, are all determined simultaneously during the screening process with dynamic light scattering (DLS) tools in order to rank the effectiveness of candidates and formulation conditions.
Accelerating the Development of Optimized Therapeutic Protein Formulations using Differential Scanning Calorimetry
Malvern Instruments Limited

DSC data is useful in predicting the stability of a protein in solution. The Tm indicates thermostability, and Tm determination in different formulations is an approximate measure of the susceptibility to aggregation and other irreversible changes at lower temperatures.
Differentiation and characterization of subvisible particulates in therapeutic protein products
Malvern Instruments Limited

The formation of protein aggregates is a particular concern for parenteral administration biopharmaceuticals due to the potential for increased immunogenicity.
An Introduction to Proteins in 30 minutes
Malvern Instruments Limited

In the biotechnology industry, the majority of research is directed towards characterizing the structure and function of proteins. New methods are continually being developed to accomplish this.
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
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