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Featured Products
Next Generation, Chemically Defined Supplements
Next Generation, Chemically Defined Supplements
Best Quality Insulin for Cell Culture
Best Quality Insulin for Cell Culture

Webcasts
Your body is 3D, why is your cell culture not?Your body is 3D, why is your cell culture not?
Christian Oberdanner, PhD, Application Specialist Sales & Marketing, Tecan Austria GmbH
Library Design for Tackling Protein-protein Interactions: The 2P2I ApproachLibrary Design for Tackling Protein-protein Interactions: The 2P2I Approach
Dr Philippe Roche, CNRS, speaking at Discovery Chemistry Congress 2013.

Market Reports
Security Technologies in Biotechnology
RI Technologies

The report serves as a guide to security technology industry for biotechnology applications, covering more than 350 companies that are engaged in security technology/products and services.
Biologics
RI Technologies

This report on Biologics gives a market insight into products types including Monoclonal Antibodies, Blood & Blood Products, Vaccines, Insulin and Other, for both human and animal consumption.
China Pharmaceutical Market Outlook
Global Data

The report details the macroeconomic environment of China, providing a background of the financial and demographic situations in the country, as well as identifying key demographics. It covers the pharmaceutical market broken down by market segment, and the popularity of biosimilars and biologics, identifying where the strongest market potentials lie.
Biomarkers in Drug Discovery - Integration in Early Stage Promotes Use of Companion Diagnostics to Optimize Therapeutic Outcomes
Global Data

The report describes the history of biomarkers and their role in fulfilling the unmet needs of the conventional drug discovery process. The drivers and barriers for the biomarkers market, along with the key issues faced in the application of biomarkers in the drug discovery process, are highlighted.
Drug Discovery and Development Market in Asia
Global Data

The report provides key data, information and analysis of the major trends and issues affecting the drug discovery and development market in seven major countries in Asia, namely China, India, Russia, Japan, Singapore, Taiwan and South Korea.
Biopharmaceutical Manufacturing in India, China and South Korea
GBI Research

The report provides an analysis of biopharmaceuticals approved in 2010 and 2011, operating dynamics in the biopharmaceutical industry, the current scenario in biopharmaceutical manufacturing, key stakeholders, the current market size (2011) of biopharmaceuticals, and forecasts to 2016 for India, China, South Korea and the global market.
Innovation in the Prefilled Syringe Market - Biologics and Autoinjection Devices Shaping Future R&D Trends
Global Data

The report provides insights into possible future avenues of R&D in the prefilled syringe market. This includes an overview of problems and possible solutions, as well as discussion of how the devices have developed to date to address problems with contamination, safety, fragility and ease of use.
Cell Culture - Rising Demand for Biologics and Growing Visibility of Approval Pathway for Biosimilars will Create Growth Opportunities
Global Data

The report analyzes the role of biopharmaceutical products that basically provide enhancement to media, sera, reagents and cell culture market. Major manufacturing technologies involved in the cell culture technology have been detailed in the report. Furthermore, the report provides competitive benchmarking for the leading players that shape the global media, sera, reagent and overall cell culture market.
Monoclonal Antibodies Market in Rheumatoid Arthritis to 2018
GBI Research

The currently marketed monoclonal antibodies are highly successful products in the rheumatoid arthritis market, constituting four of the global top 20 best-selling drugs. Significant market exclusivity, expiries in the forecast period and yet more monoclonal antibodies in development will change the dynamics in and this highly lucrative market in the forecast period until 2018.
Preclinical Development of Monoclonal Antibodies and Related Biologicals: Emerging technologies and new therapeutic candidates
Business Insights

This report explains what monoclonal antibodies are, and why large pharmaceutical companies are investing so heavily both in developing such drugs internally and acquiring monoclonal antibody candidates from others. More than 80 popular and emerging technologies are named, explained and illustrated with original full-color diagrams.
Scientific News
Next-Generation Therapeutics for Infectious Diseases Conquer the Global Spotlight
Resistance to current drugs spurs treatment innovation in influenza, respiratory syncytial virus, chlamydia and gonorrhea.
MIT Chemists Devise Novel Way to Manufacture Peptide Drugs
New, fast synthetic method enables manufacture of peptides in hours, which could boost drug development.
VolitionRx’s NuQ® Assays Demonstrate 80% Detection Rate in Prostate Cancer
Study data also demonstrates ability to distinguish between prostate and colorectal cancer.
Optimising Vaccine Process Scale up of Attachment Dependent Cells using Micro Bioreactors and Microcarriers
Performing microcarrier culture using an automated microscale bioreactor system offers a method of improved process development for production of vaccine using attachment dependent cells.
Testosterone-Regulated Genes May Affect Vaccine-Induced Immunity
NIH-funded study helps explain differences in male and female responses to vaccines.
NIH Program Bridges Gap to Develop New Therapeutics
New projects advance treatments for acute radiation syndrome, brain injury from cardiac arrest and a rare blood disorder.
FDA Approves First Generic Versions of Antidepressant Drug Cymbalta
The U.S.FDA approved the first generic versions of Cymbalta), a prescription medicine used to treat depression and other conditions.
Bridgepoint Development Capital to Acquire Quotient Clinical
Quotient Clinical has been acquired from the Quotient Bioresearch Group by Bridgepoint Development Capital for an undisclosed sum.
UConn Chemist Discovers New Way to Stabilize Proteins
Discovery could lead to the development of stable vaccines and affordable artificial blood substitutes.
'Smuggling' Drugs at the Cellular Level
Drexel researchers use ultrasound to deliver customized medication through the skin.
Business News
Prosonix and Mylan Enter Into Global Licensing Agreement
Licensing agreement for generic versions of inhaled respiratory products Flixotide® and Flovent®.
Mucosis Announces a Strategic Partnership with Changchun BCHT Biotechnology
Company raises EUR 5 million in a new financing round.
Merck Millipore Announces Incoming CEO and President
Udit Batra, Ph.D. will be responsible for the organization’s strategic direction to drive growth and product innovation as well as oversight of the worldwide operations.
GE Healthcare Appoints Emmanuel Ligner as General Manager
Emmanuel will oversee all worldwide commercial activities of Company's rapidly growing BioProcess business.
Pittcon Announces Recipients of the Editors’ Awards
Recipients include Texas Instruments (Gold), Waters (Silver) and ABSciex (Bronze).
Mallinckrodt Pharmaceuticals to Acquire Questcor for $5.6B
Combined company expected to deliver sustainable growth built on a more diversified product platform of novel therapeutics.
Eleven BASF Sites Awarded GMP Certification for Cosmetic Ingredients
Certification confirms strict control of product quality and industry hygiene in the manufacturing process.
Gyros and Tekon Biotech Sign Distribution Agreement
Tekon will distribute Gyros’ immunoassay platform in China, Taiwan & Hong Kong.
Merck Licenses NanoBio Technology
Licensing agreement for the use of nanoemulsion (NE) adjuvant technology.
Spark Therapeutics and Genable Technologies Announce Collaboration
Collaboration to advance a gene therapy treatment for a rare form of retinitis pigmentosa.

Events
Biologics World Korea 2014 
22 Apr 2014
Biologics World Korea 2014  ...
More information
BIT
25 Apr 2014
BIT's 6th Annual Word Congress ...
More information
13th Annual Biological Product
12 May 2014
13th Annual Biological Product ...
More information
ELA: Advances in Cellular Assa
14 May 2014
ELA: Advances in Cellular Assa ...
More information

ePosters
Automated Quantitative Analysis of Ethanol, Glucose and NADH in the UV/VIS and Short NIR
University of Applied Sciences Ulm

Process Analytical Technology currently becomes more and more important for food and pharmaceutical industry for example because of the increasing demand for more effective and efficient quality control. Therefore it is necessary to get timely and targeted responses of the different parameters in bioprocesses. To attain this aim, it is helpful to replace the conventional (manual) laboratory techniques with automated measuring processes via in-line probe.
A Novel Synthetic Peptide as a Tool for Microvesicles / Exosomes isolation ©
New England Peptide, Inc

We have engineered and validated a synthetic peptide (Vn96*) with specific affinity for canonical heat shock proteins (HSPs) as a tool for rapid isolation of Exosomes or extracellular microvesicles (together referred to as eMVs here) from cell culture media, human and animal body-fluids.
Acute Infective Endocarditis: Early Surgery versus Conventional Treatment
University of Otago, Christchurch, New Zealand

Infective endocarditis (IE) refers to thew inflammation of the inner layer of the heart, the endocardium, secondary to an infectious (most commonly bacterial) agent. It affects the left side of the heart more commonly than the right. IE has an estimated incidence of 1.4 to 6.2 per 10,000 persons in the developed countries, and is most commonly caused by Staphylococcus aureus, coaguase-negative staphylococcus, Viridans group streptococci and Straptococcus bovis.
First total synthesis of Combretastatin D-2 congeners named Isocorniculatolide A and 11-o-methylisocornicultolide
JNTU Hyderabad

As a part of our ongoing research in synthesizing the Biologically important Natural Products, here we are reporting First total synthesis of newly isolated isocorniculatolide A and 11-O-methyl corniculatolide A.
Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments

Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments

TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
Improving Cell-Mediated Cytotoxicity Assessment through the Use of an Automated Luminescent ADCC Assay
BioTek Instruments

Assays that can assess the ability of a biosimilar to act in a manner similar to the original biologic have seen increased interest. This poster describes the use of a non-radioactive luminescent chemistry to simplify the assay process and provide improved data quality.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences

Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
Biopharmaceuticals Hiding in the Woods
University of New Brunswick

Suggestions are provided of how efficient industrial bioprocessing can be accomplished, independently of highly expensive molecular biology approaches, in order to recover natural products of medicinal value from wild plant species.
A Mix-and-Read Cell-Based Assay for Antibody Screening Against Epidermal Growth Factor Receptor
TTP Labtech Ltd

The conventional antibody screening assay based on antibody-antigen binding has been enzyme-linked immunosorbent assay (ELISA). While tedious and consuming, ELISA has proved sufficient for the identification of antibodies directed against secreted antigens. However, cell surface antigens (e.g. GPCRs) provide challenges for ELISA due to the shortage of soluble antigens and high variability resulting from loss of cells during wash procedures.
Application Notes
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
Tag-lite® two-cell assay: a valuable tool for protein drug discovery
Tecan Group Ltd.

Antibodies are central mediators of the immune system, IgG being the most dominant. Binding of IgG/antigen complexes to membrane-bound Fc? receptors triggers a cellular immune response. Alterations in the Fc portion of the antibody by introducing mutations can lead to complete abolition of Fc? receptor binding. This describes the development of a cellbased TR-FRET assay to determine the simultaneous binding of an antibody to its antigen and huFc?RIIIa present on different cells.
Protein Purification Workflow Development Using Bio-Rad's NCO' Chromatography System
Bio-Rad Laboratories

High purity protein is a common requirement for biochemical and structural studies. A common approach is to recombinantly express an affinity-tagged version of the protein of interest. This is, however, not always a viable option. This application note discusses protein purification workflow development for untagged proteins and introduce a new indicator of method performance, the purity quotient difference.
Direct Visualisation, Sizing and Counting of Aggregation in Proteins
NanoSight Ltd

Characterising the state of aggregation in proteins is of paramount importance when trying to understand biopharmaceutical product stability and efficacy. Product quality, both in terms of biological activity and immunogenicity can be highly influenced by the state of protein aggregation.
Direct Visualisation, Sizing & Counting of Viruses and Phages in Liquid Suspension
NanoSight Ltd

A new laser-based nanoparticle tracking analysis system is now available which allows nanoscale particles such as viruses and virus aggregates to be directly and individually visualised in liquids in real-time, from which high-resolution particle size distribution profiles can be obtained.
Automating Aqueous Compound Solubility Using the 96-Well Multiscreen® Solubility Filter Plate on a Hamilton Microlab® Star Workstation
Hamilton

Here we describe an automated method for determining drug solubility using Millipore’s MultiScreen Solubility filter plate on the Hamilton MICROLAB STAR workstation.
Contaminant bovine IgG assay
Molecular Devices

Fetal calf serum containing bovine IgG is commonly used in mammalian cell culture media for the production of recombinant pharmaceuticals. During the purification process of a recombinant pharmaceutical, bovine IgG may be copurified with the product, and may represent a biological hazard for clinical use. Therefore, it may be necessary to assay for contaminant bovine IgG in a final product originating from mammalian cells.
LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader
Thermo Fisher Scientific

LanthaScreen technology uses time-resolved fluorescence resonance energy transfer (TR-FRET) to study multiple target classes including protein kinases, nuclear hormone receptors, as well as proteases and ubiquitinated proteins.
Integrated Solutions for High-Throughput Bioprocessing Applications
Thermo Fisher Scientific

Advances in blood banking, industrial biotechnology, bio-production and pharmaceutical laboratories have driven the need to process multiple sample batches.
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