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Friday, August 22, 2014
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Webcasts
A Potentially Scalable Method for the Harvesting of hMSCs from Microcarriers: Initial ResultsA Potentially Scalable Method for the Harvesting of hMSCs from Microcarriers: Initial Results
Qasim Rafiq, Loughbrough University, speaking at Advances in Cellular Assays & Cell Culture 2014
Magneto-plasmonic Nanoparticle Platform for Capture, Separation and Enumeration of Rare CellsMagneto-plasmonic Nanoparticle Platform for Capture, Separation and Enumeration of Rare Cells
Konstantin Sokolov, The University of Texas at Austin, speaking at Nanomedicine 2014.

Market Reports
Label-Free Binding Analysis Trends 2014
HTStec

This market report summarizes the results of HTStec’s 4th global web-based benchmarking survey on label-free (LF) binding analysis carried out in July 2014. The study was initiated by HTStec as part of its regular (every 2 years) tracking of this life science marketplace. The questionnaire was compiled to address the needs and interests of the LF binding analysis vendor community.
Analytical Instrument Market in the US 2014-2018
Infinity Research

TechNavio's report focuses on the US and has been prepared based on an in-depth market analysis with inputs from industry experts.
Chromatography Resin Market by Application, Techniques & Type - Trends & Forecast to 2018
MarketsandMarkets

The chromatography resin market is expected to grow at a decent pace during the coming decade driven by its increasing application in monoclonal antibody production and food analytics.
Chromatography Accessories and Consumables Market by Types, Technology & End-users - Trends & Global Forecasts to 2018
MarketsandMarkets

The chromatography accessories and consumables market demands significant investments in R&D in order to constantly come up with new and innovative products and technologies.
Chromatography Reagents Market By Type, Bed Shape, Mobile Phase, Separation Mechanism & End User - Global Forecasts to 2018
MarketsandMarkets

The market is expected to witness a high growth due to high demand of chromatography reagents in the growing pharmaceutical market.
Molecular Spectroscopy Market by Technology & Application - Forecast to 2018
MarketsandMarkets

Over the years, the molecular spectroscopy market, comprising instruments, consumables, and services, has witnessed various technological advancements. These advancements have led to a growth in the number of molecular spectroscopy applications.
Biosimilars Market Product & Application - Global Forecast to 2018
MarketsandMarkets

The biosimilar products market is segmented into recombinant non-glycosylated proteins, recombinant glycosylated proteins, and recombinant peptides.
Security Technologies in Biotechnology
RI Technologies

The report serves as a guide to security technology industry for biotechnology applications, covering more than 350 companies that are engaged in security technology/products and services.
Biologics
RI Technologies

This report on Biologics gives a market insight into products types including Monoclonal Antibodies, Blood & Blood Products, Vaccines, Insulin and Other, for both human and animal consumption.
China Pharmaceutical Market Outlook
Global Data

The report details the macroeconomic environment of China, providing a background of the financial and demographic situations in the country, as well as identifying key demographics. It covers the pharmaceutical market broken down by market segment, and the popularity of biosimilars and biologics, identifying where the strongest market potentials lie.
Scientific News
Experimental Chikungunya Vaccine Induces Robust Antibody Response
Vaccine developed by NIH scientists performs well in early clinical trial.
The Future of Targeted Therapy in Rheumatology: Biologics or Small Molecules?
While biologics can modulate extracellular protein-protein interactions, intracellular processes can be more effectively targeted by small molecules.
Injected Vaccine Could Help Eradicate Polio
Re-introducing a type of polio vaccine that fell out of favour in the 1960s could hasten eradication of the disease.
Can Regenerative Medicine be the Cure for Cancer and Other Deadly Diseases?
Change in regulatory frameworks and standards are essential to expedite approval and release of innovative products.
A Key Step Toward a Safer Strep Vaccine
Gene discovery identifies molecular pathway to potential preventive treatment.
Separation of mAbs Molecular Variants by Analytical HIC-HPLC
HIC-HPLC is a less widely used analytical technique compared with standard methods for separating variants based on size, charge or electrophoretic mobility.
HIV Vaccine Awareness Day
Early stage vaccine clinical trials are expected to begin in South Africa in early 2015.
Decline in Whooping Cough Cases Continues
PHE publish whooping cough figures which are on a decline across England.
Scripps Researchers Find New Point of Attack on HIV for Vaccine Development
The newly identified site can be attacked by human antibodies in a way that neutralizes the infectivity of a wide variety of HIV strains.
Next-Generation Therapeutics for Infectious Diseases Conquer the Global Spotlight
Resistance to current drugs spurs treatment innovation in influenza, respiratory syncytial virus, chlamydia and gonorrhea.
Business News
GE Healthcare Life Sciences to Create New US Headquarters
When fully operational, the new facility will house more than 500 highly skilled employees and bring more than 220 new jobs to Massachusetts.
Fujifilm Diosynth Biotechnologies Expands Cell Culture Manufacturing Capacity
The company expands capabilities with the addition of two new 2,000l single-use bioreactors.
Miltenyi Biotec Acquires Gene Therapy Assets from Lentigen Corporation
Addition of lentiviral gene delivery capabilities complements strategic partnering portfolio.
Merck Millipore Invests €12M in France Facility
The investments will expand ready-to-use media manufacturing at company's Molshiem facility.
Baxter Opens its First Biologics Facility in Asia
Singapore-based facility enhances the company’s global capabilities to support the treatment needs of hemophilia patients worldwide.
Redbiotec, GE Healthcare CMV Vaccine Collaboration
Companies combine expertise to produce cytomegalovirus vaccine candidates.
Roche to Acquire Santaris Pharma
Acquisition to expand Roche's discovery and development of RNA-targeting medicines.
International Bioprinting Congress
Select Biosciences South East Asia is pleased to report on the success of the inaugural International Bioprinting Congress, which took place at the Biopolis, Singapore on the 24-25 July 2014.
Baxter Announces Divestiture of Commercial Vaccines Business to Pfizer
Baxter will sell its commercial vaccines businesses to Pfizer for $635 million.
Malvern Completes Acquisition of MicroCal
Company announces purchase of Archimedes product from Affinity Biosensors.

Events
SLAS Short Courses
01 Sep 2014
SLAS Short Courses ...
More information
ELRIG - Drug Discovery 2014
02 Sep 2014
ELRIG - Drug Discovery 2014 ...
More information
Vaccine World Summit China 201
04 Sep 2014
Vaccine World Summit China 201 ...
More information
Technology Transfer for Biolog
15 Sep 2014
Technology Transfer for Biolog ...
More information

ePosters
The Effects of Dimethylphthalate on the Viability and Development of Drosophila melanogaster
Wagner College

My research studies the effect of dimethylphthalate (DMP), a putative endocrine disruptor, on the viability and development of the model organism Drosophila melanogaster.
Comparison of Three Methods for the Evaluation of Cytokine Storm Risk in Early and Clinical Stage Biopharmaceutical Development
ReachBio LLC

Objective: To identify an assay that can accurately predict the risk of CRS and CS associated with investigational biotherapeutics. A comparison of three methods were used: (a) immobilization of test antibody on plastic, (b) co-culture of PBMC's on HUVEC's and (c) pre-culture of PBMC's at high cell density.
Automated Quantitative Analysis of Ethanol, Glucose and NADH in the UV/VIS and Short NIR
University of Applied Sciences Ulm

Process Analytical Technology currently becomes more and more important for food and pharmaceutical industry for example because of the increasing demand for more effective and efficient quality control. Therefore it is necessary to get timely and targeted responses of the different parameters in bioprocesses. To attain this aim, it is helpful to replace the conventional (manual) laboratory techniques with automated measuring processes via in-line probe.
A Novel Synthetic Peptide as a Tool for Microvesicles / Exosomes isolation ©
New England Peptide, Inc

We have engineered and validated a synthetic peptide (Vn96*) with specific affinity for canonical heat shock proteins (HSPs) as a tool for rapid isolation of Exosomes or extracellular microvesicles (together referred to as eMVs here) from cell culture media, human and animal body-fluids.
Acute Infective Endocarditis: Early Surgery versus Conventional Treatment
University of Otago, Christchurch, New Zealand

Infective endocarditis (IE) refers to thew inflammation of the inner layer of the heart, the endocardium, secondary to an infectious (most commonly bacterial) agent. It affects the left side of the heart more commonly than the right. IE has an estimated incidence of 1.4 to 6.2 per 10,000 persons in the developed countries, and is most commonly caused by Staphylococcus aureus, coaguase-negative staphylococcus, Viridans group streptococci and Straptococcus bovis.
First total synthesis of Combretastatin D-2 congeners named Isocorniculatolide A and 11-o-methylisocornicultolide
JNTU Hyderabad

As a part of our ongoing research in synthesizing the Biologically important Natural Products, here we are reporting First total synthesis of newly isolated isocorniculatolide A and 11-O-methyl corniculatolide A.
Automated Solutions for Cellular Screening and Characterization of Therapeutic Antibodies for Antibody-Dependent Cellular Cytotoxicity Utility
BioTek Instruments

Since the end of the 1990’s, the pharmaceutical industry has seen an increased interest in biologics, especially in the therapeutic areas of oncology and inflammation. Here we present the automation of two assays for the characterization and selection of potent antibody drug candidates. Both assays rely on HTRF® detection. The first assay quantifies the binding affinity of antibodies to their target antigen, on live cells.
Validation of an Automated Cell-Based Bioluminescent TNFa Blocker Bioassay
BioTek Instruments

TNFa blocker biopharmaceuticals represent an important and successful class of protein drugs used in the treatment of several autoimmune diseases. Bioassays are indispensible tools in biopharmaceutical drug development and commercialization that are used to quantify biological activity and stability of drugs or drug candidates. The automation of these assays can serve to create an accurate, robust process which can allow the researcher to perform other more important functions.
Improving Cell-Mediated Cytotoxicity Assessment through the Use of an Automated Luminescent ADCC Assay
BioTek Instruments

Assays that can assess the ability of a biosimilar to act in a manner similar to the original biologic have seen increased interest. This poster describes the use of a non-radioactive luminescent chemistry to simplify the assay process and provide improved data quality.
Antigen Determination in Autoimmune Hepatitis Type1
Institute of Liver and Biliary Sciences

Objectives of this project were to exploit the database in indian setting to determine nuclear antigens as target for antinuclear antibodies (ANA) in patients of autoimmune hapatitis (AIH) type1.
Application Notes
Differentiation and characterization of subvisible particulates in therapeutic protein products
Malvern Instruments Limited

The formation of protein aggregates is a particular concern for parenteral administration biopharmaceuticals due to the potential for increased immunogenicity.
An Introduction to Proteins in 30 minutes
Malvern Instruments Limited

In the biotechnology industry, the majority of research is directed towards characterizing the structure and function of proteins. New methods are continually being developed to accomplish this.
Performing ADCC Reporter Bioassay with an Environmentally Controlled Microplate Reader
Tecan Group Ltd.

The Promega ADCC Reporter Bioassay provides effector and target cells in frozen, thaw-and-use format, removing the need for isolating or culturing cells in order to perform the assay. Reporter induction requires a six-hour to overnight incubation in a standard cell culture incubator. The CO2 and temperature control features of the Tecan Infinite® 200 PRO with GCM allow the assay induction to be performed without the requirement for a cell culture incubator.
Tag-lite® two-cell assay: a valuable tool for protein drug discovery
Tecan Group Ltd.

Antibodies are central mediators of the immune system, IgG being the most dominant. Binding of IgG/antigen complexes to membrane-bound Fc? receptors triggers a cellular immune response. Alterations in the Fc portion of the antibody by introducing mutations can lead to complete abolition of Fc? receptor binding. This describes the development of a cellbased TR-FRET assay to determine the simultaneous binding of an antibody to its antigen and huFc?RIIIa present on different cells.
Protein Purification Workflow Development Using Bio-Rad's NCO' Chromatography System
Bio-Rad Laboratories

High purity protein is a common requirement for biochemical and structural studies. A common approach is to recombinantly express an affinity-tagged version of the protein of interest. This is, however, not always a viable option. This application note discusses protein purification workflow development for untagged proteins and introduce a new indicator of method performance, the purity quotient difference.
Direct Visualisation, Sizing and Counting of Aggregation in Proteins
NanoSight Ltd

Characterising the state of aggregation in proteins is of paramount importance when trying to understand biopharmaceutical product stability and efficacy. Product quality, both in terms of biological activity and immunogenicity can be highly influenced by the state of protein aggregation.
Direct Visualisation, Sizing & Counting of Viruses and Phages in Liquid Suspension
NanoSight Ltd

A new laser-based nanoparticle tracking analysis system is now available which allows nanoscale particles such as viruses and virus aggregates to be directly and individually visualised in liquids in real-time, from which high-resolution particle size distribution profiles can be obtained.
Automating Aqueous Compound Solubility Using the 96-Well Multiscreen® Solubility Filter Plate on a Hamilton Microlab® Star Workstation
Hamilton

Here we describe an automated method for determining drug solubility using Millipore’s MultiScreen Solubility filter plate on the Hamilton MICROLAB STAR workstation.
Contaminant bovine IgG assay
Molecular Devices

Fetal calf serum containing bovine IgG is commonly used in mammalian cell culture media for the production of recombinant pharmaceuticals. During the purification process of a recombinant pharmaceutical, bovine IgG may be copurified with the product, and may represent a biological hazard for clinical use. Therefore, it may be necessary to assay for contaminant bovine IgG in a final product originating from mammalian cells.
LanthaScreen TR-FRET Assay Performance with Thermo Scientific Varioskan Flash Spectral Scanning Multimode Reader
Thermo Fisher Scientific

LanthaScreen technology uses time-resolved fluorescence resonance energy transfer (TR-FRET) to study multiple target classes including protein kinases, nuclear hormone receptors, as well as proteases and ubiquitinated proteins.
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