Corporate Banner
Satellite Banner
Biologics & Bioprocessing
Scientific Community
Become a Member | Sign in
Home>News>This Article

Trophos Announces Conclusion of MitoTarget Consortium

Published: Wednesday, August 01, 2012
Last Updated: Wednesday, August 01, 2012
Bookmark and Share
EU funded 3-year project spearheaded by orphan disease specialist Trophos reports results from neurodegenerative program to the European Commission.

Trophos SA has announced the conclusion of the pan-European MitoTarget Project, the EU funded orphan disease project, with submission of the final report to the EC.

The results obtained in this project included additional confirmation that mitochondrial dysfunction plays an important role in neuron death, and therefore the progression of neurodegenerative diseases.

The MitoTarget project contributed towards broader research required to discover which dysfunction/s is the leading cause of neurodegenerative diseases, key to finding effective drug targets in the future.

It also further confirmed that Trophos’ lead drug candidate olesoxime, currently in an ongoing pivotal trial for the orphan neuromuscular disease Spinal Muscular Atrophy (SMA), targets mitochondria.

Various changes in mitochondrial function, distribution or number were found in all experimental models of neurodegenerative diseases including Alzheimer's Disease, Huntington's Disease, Hereditary Spastic Paraplegia (HSP), Amyotrophic Lateral Sclerosis (ALS), and even general aging.

There were very promising results obtained in models of ALS, Huntington's Disease and Alzheimer's Disease.

Evidence produced by MitoTarget also proved mitochondrial targeted drugs should provide a part of the therapeutic strategy of neurodegenerative diseases.

Combination therapeutics will be essential to attack multiple aspects of the disease including both the causes and the symptoms.

Trophos and the consortium have already published many of their results and further publications are planned describing results of the basic research as well as the clinical trial in ALS to aid all parties involved in future research to work towards eradicating and curing diseases that include SMA, Alzheimer's Disease, Huntington’s Disease as well as ALS.

The three-year project was initiated in 2007 with the creation of the consortium, commencing the main part of the activity in 2009, and was funded by the EU.

Advocates included the British theoretical physicist, Stephen Hawking, CH, CBE, FRS, FRSA, and a patron of the Motor Neurone Disease Association.

Led by Trophos, the MitoTarget consortium consisted of 17 partners from four European countries (France, Germany, United Kingdom, and Belgium).

Fourteen of the partners as well as a centre in Spain participated in the clinical trial element of the project and five basic research groups focused on understanding the underlying mechanisms of neurodegenerative diseases.

“Trophos has been deeply honored to have led the MitoTarget Consortium, which has made significant discoveries that will help future research into neurological diseases,” said Rebecca Pruss, MitoTarget project principle investigator and Trophos’ chief scientific officer.

Pruss continued, “The research section of the project made considerable progress that will greatly contribute to, and benefit future efforts to find therapies for Alzheimer’s, Parkinson’s, Huntington’s diseases, ALS and other neurodegenerative diseases including Multiple Sclerosis.”

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Trophos Announces Results of Phase III Study of Olesoxime in ALS
Company continues its ongoing programs and financed until at least the end of 2013.
Wednesday, December 14, 2011
Scientific News
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Speeding Up the Process of Making Vaccines
System uses a freeze-dry concept to develop "just-add-water" solution.
Surprising Trait Found in Anti-HIV Antibodies
Scientists at The Scripps Research Institute (TSRI) have new weapons in the fight against HIV.
New Method Identifies Up to Twice as Many Proteins and Peptides
An international team of researchers developed a method that identifies up to twice as many proteins and peptides in mass spectrometry data than conventional approaches.
The Do’s and Don’ts of SPR Experiments
Surface Plasmon Resonance (SPR) is a technique that is becoming more widely used, particularly by anyone who wants to obtain accurate on (association) and off (dissociation) rates for biomolecular binding.
Genetically Engineering Algae to Kill Cancer Cells
New interdisciplinary research has revealed the frontline role tiny algae could play in the battle against cancer, through the innovative use of nanotechnology.
Novel Stem Cell Line Avoids Risk of Introducing Transplanted Tumors
Progenitor cells might eventually be used to repair or rebuild damaged or destroyed organs.
Single Vaccine for Chikungunya, Related Viruses May be Possible
What if a single vaccine could protect people from infection by many different viruses? That concept is a step closer to reality.
Blocking the Transmission Of Malaria Parasites
Vaccine candidate administered for the first time in humans in a phase I clinical trial led by Oxford University’s Jenner Institute, with partners Imaxio and GSK.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos