Corporate Banner
Satellite Banner
Biologics & Bioprocessing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Researchers Awarded Almost £1 Million to Target High Blood Pressure

Published: Tuesday, August 21, 2012
Last Updated: Tuesday, August 21, 2012
Bookmark and Share
Study shows that reduced blood flow to the brain will trigger high blood pressure.

University of Bristol researchers have received funding of almost £1 million from the British Heart Foundation to provide novel therapeutic targets for the treatment of high blood pressure.

Affecting one in three people, the treatment of patients with high blood pressure has important clinical and financial implications for public health.

Although scientists know what factors can trigger high blood pressure many of the mechanisms that regulate the long-term control of blood pressure remain a mystery.

Scientists from the University’s School of Physiology and Pharmacology, who are leading the five-year study, believe that these underlying mechanisms are triggered by poor blood delivery to the brain which responds by pushing blood pressure up causing high blood pressure.

This process re-directs blood into the brain to restore adequate flow. In previous studies, involving patient and an animal model of human hypertension, the blood vessels supplying the brain with blood are narrow and resistant to flow.

They also fail to dilate when brain activity increases, which is a time when more blood flow is needed to deliver oxygen and nutrients. So, there appears a greater susceptibility for stroke in high blood pressure.

The study aims to provide new evidence that shows reduced blood flow to the brain will trigger high blood pressure and provide novel therapeutic targets for the treatment of high blood pressure.

Professor Julian Paton, the study’s lead scientist, said: “You have to consider the brain as the most selfish organ in the body; if it is not satiated with enough blood flow it is the most powerful organ in the body for ramping up the pressure.

“We are absolutely delighted to have been given this award from the British Heart Foundation as it directs much needed attention to the brain and provides the opportunity to come up with new ways to control blood pressure in patients that are devoid of the awful side effects of so many currently prescribed drugs.”

Professor Sergey Kasparov, co-investigator on the study added: “We will attempt to prevent the narrowing of brain arteries in high blood pressure so to improve blood flow, unearth the intra-cranial sensors that detect low brain blood flow that trigger high blood pressure and find out why brain vessels are reluctant to dilate when brain activity increases.”

Dr Hélène Wilson, Research Advisor at the British Heart Foundation (BHF), said: “We’re delighted to award almost £1 million to this Bristol team for their work on understanding the causes of high blood pressure, which can lead to greater risk of having a heart attack or stroke. This latest project is looking at a possible role for the brain in effective blood pressure control, and is part of a wide research programme that we hope will help lead us towards new treatments in the future."

The study, entitled ‘Brainstem hypoperfusion as a causative mechanism for neurogenic hypertension’ led by Professor Julian Paton at the University of Bristol, is funded by a British Heart Foundation grant of £980,415.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

New Findings Could Influence the Development of Therapies to Treat Dengue Disease
New research into the fight against Dengue may influence the development of anti-viral therapies that are effective against all four types of the virus.
Monday, August 05, 2013
Scientific News
Immunotherapy Agent Benefits Patients with Drug-Resistant Multiple Myeloma in First Human Trial
Daratumumab proved generally safe in patients, even at the highest doses.
Inciting an Immune Attack On Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Less May Be More in Slowing Cholera Epidemics
Mathematical model shows more cases may be prevented and more lives saved when using one dose of cholera vaccine instead of recommended two doses.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Flu Remedies Help Combat E. coli Bacteria
Physiologists from the University of Zurich have now discovered why the intestinal bacterium Escherichia coli (E. coli) multiplies heavily and has an inflammatory effect.
'Fountain of Youth' Protein Points to Possible Human Health Benefit
Patients with higher blood levels of growth factor have lower risk of cardiovascular problems.
Lemon Juice and Human Norovirus
Citric acid may prevent the highly contagious norovirus from infecting humans, scientists discovered from the German Cancer Research Center.
Study Backs Flu Vaccinations for Elderly
Brown University researchers found vaccines well matched to the year’s flu strain significantly reduce deaths and hospitalizations compared to when the match is poor, suggesting that vaccination indeed makes a difference.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Protein Found to Play a Key Role in Blocking Pathogen Survival
Calprotectin fends off microbial invaders by limiting access to iron, an important nutrient.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!