Corporate Banner
Satellite Banner
Biologics & Bioprocessing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Purdue Researcher's New 'Tool for the Organic Chemist Toolbox' Licensed to Sigma-Aldrich

Published: Friday, May 24, 2013
Last Updated: Friday, May 24, 2013
Bookmark and Share
U.S. patent for a safer, easier and "greener" method to incorporate fluorine into organic compounds has been licensed to a subsidiary of Sigma-Aldrich Corporation.

David A. Colby, a Purdue assistant professor of medicinal chemistry and organic chemistry, developed a chemical reagent that safely makes fluorine available during the creation of a new chemical compound. This reagent could provide drug manufacturers an improved method for using fluorine in the drug discovery process and enhance large-scale production of drugs for pharmaceutical manufacturers.

Aldrich Chemical Co. LLC has licensed the technology and will make the product available for sale through the Sigma-Aldrich catalog and website. Aldrich signed the license agreement with the Purdue Research Foundation and its Purdue Office of Technology Commercialization.

"Fluorine-carbon bonds are incredibly strong and are the secret to the strength of materials like Teflon and agricultural treatments that withstand the elements, and they also help pharmaceuticals hold up well inside our bodies," Colby said. "Fluorine has greatly advanced these industries, and now we have solved a key problem associated with using a commonly available starting material, fluoroform gas, an environmental hazard that is difficult to use in the laboratory. What we've done is create a new tool for the chemist's toolbox."

Fluoroform gas requires special handling and protection of the user and produces ozone-destroying fluorocarbons if released into the atmosphere. The reagent Colby developed is a stable solid that can be easily stored at room temperature, weighed and measured in the open air and requires no unusual protection measures. The reagent also has little waste and is made up of compounds that are safe for the environment. Once safely added to a solvent contained in the chemical processing equipment, the reagent releases fluoroform gas that is easily incorporated into the chemical process, he said.

Pharmaceutical companies have long recognized the beneficial effects of fluorine atoms in drug molecules because of their ability to improve such things as drug delivery, selectivity and efficacy. About 20 percent of all drugs on the market contain fluorine, including three of the current top-10 best-selling drugs including Lipitor® and Prevacid®.

"A chemist must have ways to manipulate properties in order to study the effectiveness of a drug," Colby said.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,500+ scientific posters on ePosters
  • More than 3,700+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Bird Flu Expert Working on Vaccine that Protects Against Multiple Strains
As the bird flu outbreak in China worsens, a Purdue University expert is working on vaccines that offer broader protection against multiple strains of the virus.
Friday, May 10, 2013
Discovery Points to New Approach to Fight Dengue Virus
Researchers have discovered that rising temperature induces key changes in the dengue virus when it enters its human host, suggests new approach for designing vaccines against the aggressive mosquito-borne pathogen.
Monday, April 15, 2013
Researcher Taking Shot at Flu Vaccine That's More Effective, Easier to Make
In the midst of an unusually deadly flu season and armed with a vaccine that only offers partial protection, researcher is working on a flu vaccine that overcomes the need to predict which strains will hit each year.
Monday, February 11, 2013
Scientific News
Less May Be More in Slowing Cholera Epidemics
Mathematical model shows more cases may be prevented and more lives saved when using one dose of cholera vaccine instead of recommended two doses.
NIH Launches Human RSV Study
Study aims to understand infection in healthy adults to aid development of RSV medicines, vaccines.
Flu Remedies Help Combat E. coli Bacteria
Physiologists from the University of Zurich have now discovered why the intestinal bacterium Escherichia coli (E. coli) multiplies heavily and has an inflammatory effect.
'Fountain of Youth' Protein Points to Possible Human Health Benefit
Patients with higher blood levels of growth factor have lower risk of cardiovascular problems.
Lemon Juice and Human Norovirus
Citric acid may prevent the highly contagious norovirus from infecting humans, scientists discovered from the German Cancer Research Center.
Study Backs Flu Vaccinations for Elderly
Brown University researchers found vaccines well matched to the year’s flu strain significantly reduce deaths and hospitalizations compared to when the match is poor, suggesting that vaccination indeed makes a difference.
Inciting an Immune Attack on Cancer Cells
A new minimally invasive vaccine that combines cancer cells and immune-enhancing factors could be used clinically to launch a destructive attack on tumors.
Protein Found to Play a Key Role in Blocking Pathogen Survival
Calprotectin fends off microbial invaders by limiting access to iron, an important nutrient.
Major Advance Toward More Effective, Long-Lasting Flu Vaccine
Collaboration shows vaccine candidate can produce powerful ‘broadly neutralizing antibodies’ in animal models.
Immune System: Help for Killer Cells
A study from the University of Bonn may show the way to more effective vaccines.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,700+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!