Corporate Banner
Satellite Banner
Biologics & Bioprocessing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Autifony Announces Collaboration with Universities of Manchester and Newcastle

Published: Monday, July 01, 2013
Last Updated: Monday, July 01, 2013
Bookmark and Share
£2.75 million research collaboration to progress a first-in-class drug for schizophrenia.

Autifony Therapeutics Limited has announced a collaboration with research groups at the University of Manchester and Newcastle University to develop a novel, first-in-class Kv3 potassium channel modulator for the treatment of schizophrenia.

The £2.75 million research collaboration is part-funded by the award of a £1.9 million grant to Autifony and the two Universities, by the UK’s innovation agency, the Technology Strategy Board.

The award follows a successful funding application to the Biomedical Catalyst, jointly funded by the Technology Strategy Board and the Medical Research Council.

Autifony’s lead programme is developing first-in-class Kv3 potassium channel modulators for hearing loss and tinnitus. This new collaboration aims to develop pharmaceutical compounds against the same target but with profiles differentiated and distinct from its hearing programme.

Autifony and its collaborators will explore the modulation of this novel voltage gated potassium channel mechanism as a potential new therapy for schizophrenia.

A serious psychiatric illness that has seen diminishing investment in research in recent years, schizophrenia remains an area of high unmet medical need, with existing schizophrenia treatments demonstrating poor efficacy for many patients as well as causing considerable side effects.

The condition imposes a huge social and economic burden.

The funding award will be used to enable selection of a compound from a group of potential candidates and then progression of the chosen compound through preclinical development up to a CTA/IND submission.

Autifony is working closely with leading academic collaborators, Professors Neill, Williams and Deakin at the University of Manchester, and Drs Cunningham and LeBeau at Newcastle University, whose pioneering models of schizophrenia will give further validation of the target and insight into the disease pathology.

Dr Charles Large, Chief Scientific Officer of Autifony, commented: “The opportunity provided by this grant to work on a new approach to schizophrenia, for which novel and more effective treatments are urgently needed, is hugely exciting. The ion channels that we are targeting in our hearing loss programme are closely implicated in brain circuits which are believed to be dysfunctional in schizophrenia. Working with academic collaborators renowned in their respective fields will bring the latest techniques and thinking to bear on this important health challenge.”


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,300+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
Shedding Light on HIV Vaccine Design
Broadly speaking - Mathematical modelling of host-pathogen coevolution sheds light on HIV vaccine design.
New Method of Cancer Immunotherapy
Stanford chemists have dicovered a new form of cancer immunotherapy using sugar presence manipulation.
Vortex Ring Freezing Applications
Accidental lab discovery could aid cell delivery and cell-free protein production.
Examining Immune Memory
Researchers investigate the 'storage/research for the future' functions of antibodies and understanding of B cells.
Expanding the Stable of Workhorse Yeasts
New genome sequences target the next generation of yeasts with improved biotechnology uses.
How Cloud Connectivity Can Combat the Reproducibility Crisis
This infographic explains the reproducibility crisis, and how cloud connectivity can help overcome this problem.
Blocking the Migration of Cancer Cells to Destroy Them
Scientists in Geneva developed an antibody able to fight off lymphomas.
Mutations Linked to Immunotherapy Resistance
Researchers uncover mutations in tumors of three patients with advanced melanoma that allowed the tumors to become resistant to the immune checkpoint inhibitor pembrolizumab (Keytruda®).
Refuelling the Cancer Fight
Scientists have discovered that the microenvironment supporting cancer tumors starves immune cells of 'fuel', preventing tumour destruction.
Obesity Inhibits Influenza Vaccine Response
Researchers have shown that obesity in mice has detrimental effect on influenza vaccine response.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,300+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!