Corporate Banner
Satellite Banner
Biologics & Bioprocessing
Scientific Community
Become a Member | Sign in
Home>News>This Article

Meningitis Mass Vaccination Sees Cases Drop 94%

Published: Monday, September 16, 2013
Last Updated: Monday, September 16, 2013
Bookmark and Share
A mass vaccination campaign in Chad in 2011 reduced all cases of meningitis by 94% and saw no cases of serogroup A meningococcal meningitis detected in 2012.

The finding comes from an evaluation by an international team including Oxford University scientists and led by the London School of Hygiene & Tropical Medicine and Centre de Support en Santé Internationale (CSSI) in Chad.

Several groups of bacteria can cause meningitis, the most important being meningococcus, which can trigger inflammation around the brain and spinal cord leading to disabilities such as deafness, paralysis, or death. The team looked at how a vaccine targeting serogroup A, the most common meningococci group in sub-Saharan Africa, affected both cases of infection and the number of people carrying the disease – carriers, who can transmit the infection through coughing and sneezing, can be detected by analysing throat swabs.

Approximately 1.8 million people aged 1-29 years received a single dose of PsA-TT (also known as MenAfriVac ®) in three regions of Chad in December 2011. The incidence of meningitis of any kind in these regions during the 2012 meningitis season was 2.5 per 100,000 people, compared to an incidence of 43.6 per 100,000 in regions where mass vaccination had not been undertaken – a 94% drop in the incidence of meningitis. No cases of serogroup A meningococcal meningitis were detected in the three vaccinated regions.

Oxford University researchers, led by Professor Martin Maiden in the Department of Zoology, played a key role in the research by designing and leading the molecular characterisation of the bacterial specimens for the study. This involved developing and applying new genome-based approaches for identifying disease-associated and harmless meningococci present in throat swab samples.

'These approaches had to be rapid and precise yet inexpensive and were applied in Oxford to thousands of specimens collected in Chad,' said Professor Maiden. 'Our results demonstrate the effectiveness of the vaccine in halting a large epidemic in Chad and shows that the vaccine worked by preventing the transmission of the epidemic strain among healthy carriers. These findings will be valuable in designing vaccination programmes aimed at eliminating group A meningococcal disease from the "meningitis belt" of Africa.'

Professor Sir Brian Greenwood from the London School of Hygiene & Tropical Medicine, lead author of the study, said: 'This is one of the most dramatic outcomes from a public health intervention that I have seen during a long career of research in Africa. There are now real prospects that the devastating effects of this infection in Africa can be prevented.'

Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,800+ scientific posters on ePosters
  • More than 4,000+ scientific videos on LabTube
  • 35 community eNewsletters

Sign In

Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

£17M Project Launched to Develop HIV Vaccine
A new €23 million (£17 million) initiative to accelerate the search for an effective HIV vaccine has begun.
Wednesday, November 11, 2015
Blocking the Transmission Of Malaria Parasites
Vaccine candidate administered for the first time in humans in a phase I clinical trial led by Oxford University’s Jenner Institute, with partners Imaxio and GSK.
Tuesday, November 10, 2015
Ebola Vaccine Trial Begins in Senegal
A clinical trial to evaluate an Ebola vaccine has begun in Dakar, Senegal, after initial research started at the Jenner Institute, Oxford University.
Thursday, July 16, 2015
Oxford Vaccine Group Begins First Trial of New Ebola Vaccine
Oxford University doctors and scientists are starting the first safety trial of an experimental preventative Ebola vaccine regimen being developed by the Janssen Pharmaceutical Companies of Johnson & Johnson (Janssen).
Wednesday, January 07, 2015
New Vaccine Generates Strong Immune Response Against Hepatitis C
A new hepatitis C vaccine has shown promising results in an early clinical trial at Oxford University, generating strong and broad immune responses against the virus causing the disease.
Friday, November 07, 2014
New Foot-and-Mouth Vaccine is Safer and Cheaper to Produce
A new vaccine against foot-and-mouth disease that is safer to produce and easier to store has been developed by scientists from the University of Oxford and The Pirbright Institute.
Thursday, March 28, 2013
Oxford's Role in New Meningitis Vaccine
EMA recommends Novartis' Bexero (MenB) vaccine to protect children against meningitis B.
Thursday, November 22, 2012
First Trial of a New Hepatitis C Vaccine Shows Promise
A new vaccine against the chronic liver disease hepatitis C has shown promising results in a first clinical trial in humans, Oxford University researchers report.
Thursday, January 05, 2012
Scientific News
"Good" Mozzie Virus Might Hold Key to Fighting Human Disease
Australian scientists have discovered a new virus carried by one of the country’s most common pest mosquitoes.
World’s First Therapeutic Venom Database
Open-source library describes nearly 43,000 effects on the human body.
Speeding Up the Process of Making Vaccines
System uses a freeze-dry concept to develop "just-add-water" solution.
Surprising Trait Found in Anti-HIV Antibodies
Scientists at The Scripps Research Institute (TSRI) have new weapons in the fight against HIV.
New Method Identifies Up to Twice as Many Proteins and Peptides
An international team of researchers developed a method that identifies up to twice as many proteins and peptides in mass spectrometry data than conventional approaches.
The Do’s and Don’ts of SPR Experiments
Surface Plasmon Resonance (SPR) is a technique that is becoming more widely used, particularly by anyone who wants to obtain accurate on (association) and off (dissociation) rates for biomolecular binding.
Genetically Engineering Algae to Kill Cancer Cells
New interdisciplinary research has revealed the frontline role tiny algae could play in the battle against cancer, through the innovative use of nanotechnology.
Novel Stem Cell Line Avoids Risk of Introducing Transplanted Tumors
Progenitor cells might eventually be used to repair or rebuild damaged or destroyed organs.
Single Vaccine for Chikungunya, Related Viruses May be Possible
What if a single vaccine could protect people from infection by many different viruses? That concept is a step closer to reality.
Blocking the Transmission Of Malaria Parasites
Vaccine candidate administered for the first time in humans in a phase I clinical trial led by Oxford University’s Jenner Institute, with partners Imaxio and GSK.

Skyscraper Banner
Go to LabTube
Go to eposters
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,800+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,000+ scientific videos