Corporate Banner
Satellite Banner
Biologics & Bioprocessing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Zetasizer Nano Used by Kiel University Researchers

Published: Tuesday, October 15, 2013
Last Updated: Tuesday, October 15, 2013
Bookmark and Share
Zetasizer Nano system used in studies on particulate vaccines for respiratory administration.

Researchers in the Department of Pharmaceutics and Biopharmaceutics at Kiel University in Germany, are using a Zetasizer Nano system from Malvern Instruments in their work on particulate vaccines formulations for administration via the respiratory tract.

Dr. Regina Scherließ leads the research group whose many recent publications include ‘PLGA nanoparticles for vaccine delivery to the respiratory tract and ‘Overcoming the challenges of nasal vaccines through intelligent particle engineering’.

“We formulate nanoparticles as antigen carriers and incorporate them into larger particles, known as nano-in-microparticles, or NiM, of a size feasible for deposition in the nose or lung,” explains Dr Scherließ.

Dr Scherließ continued, “We normally work with dry powder formulations, so the NiM will be dried, usually spray dried, at some point in the formulation process. As the particulate antigen carrier has to be taken up as a particle by the relevant immune cells, we mostly target dendritic cells and macrophages. Nanoparticle size is an important criterion for our formulations and we routinely measure this with the Zetasizer Nano.”

Particle size has to be measured directly after preparation and also upon redispersion of the NiM formulation. Redispersion often has to take place in physiological or cell culture media, and at this point the Zetasizer Nano is used to check for aggregates and particle size stability.

“We’ve also used the Zetasizer Nano for another project where we looked at stabilization of haemaglutinin during spray drying,” continued Dr Scherließ, “and as well in a project characterizing chitosan as an adjuvant. Here, we used the Zetasizer to determine the molecular weight of chitosans of different qualities.”

The Malvern Zetasizer range provides both exceptionally high performance and entry level systems that incorporate combinations of a particle size analyzer, zeta potential analyzer, molecular weight analyzer, protein mobility and microrheology measurements.

Particles and molecules from less than a nanometer in size to several microns can be analyzed by a range of variants to suit specific applications and budget.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,100+ scientific posters on ePosters
  • More than 4,500+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Malvern takes ACHEMA Visitors from R&D Through to Product QC
Visitors to the Malvern Instruments stand at ACHEMA 2012 will see how the company’s range of complementary materials characterization technologies and instrumentation support the needs of manufacturing industry.
Wednesday, March 28, 2012
Malvern Scientists will lead Protein Characterization Workshop at PEGS Summit
Drs Kevin Mattison, Ulf Nobbmann and Jason Sanchez will lead a workshop at the 7th Annual PEGS.
Tuesday, September 13, 2011
Scientific News
Developing a More Precise Seasonal Flu Vaccine
During the 2014-15 flu season, the poor match between the virus used to make the world’s vaccine stocks and the circulating seasonal virus yielded a vaccine that was less than 20 percent effective.
Fighting Cancer with Borrowed Immunity
A new step in cancer immunotherapy: researchers from the Netherlands Cancer Institute and University of Oslo/Oslo University Hospital show that even if one's own immune cells cannot recognize and fight their tumors, someone else's immune cells might.
Modified Microalgae Converts Sunlight into Valuable Medicine
A special type of microalgae can soon produce valuable chemicals such as cancer treatment drugs and much more just by harnessing energy from the sun.
Immune Cells Remember Their First Meal
Scientists at the University of Bristol have identified the trigger for immune cells' inflammatory response – a discovery that may pave the way for new treatments for many human diseases.
Paper Filter Can Remove Viruses from Water
A new paper filter can purify water from viruses, even the most difficult and contagious.
Large-scale HIV Vaccine Trial to Launch in South Africa
NIH-funded study will test safety, efficacy of vaccine regimen.
New HIV Vaccine Target Discovered
NIH-Led team have discovered a new vaccine target site on HIV.
Mimicking Evolution to Create Novel Proteins
A study by researchers in the Kuhlman lab offers a new route to design the 'cellular machines' needed to understand and battle diseases.
Antibody Therapy Opens Door to Potential New Treatment for HIV
Researchers at Rockefeller University show how a broadly neutralizing antibody could be used to help fight HIV.
Investigational Malaria Vaccine Protects Healthy U.S. Adults
Researchers at NIH have found that the malaria vaccine protected a small number of healthy, malaria-naïve adults in the U.S. from infection for more than one year after immunization.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,100+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,500+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!