Corporate Banner
Satellite Banner
Biologics & Bioprocessing
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Zetasizer Nano Used by Kiel University Researchers

Published: Tuesday, October 15, 2013
Last Updated: Tuesday, October 15, 2013
Bookmark and Share
Zetasizer Nano system used in studies on particulate vaccines for respiratory administration.

Researchers in the Department of Pharmaceutics and Biopharmaceutics at Kiel University in Germany, are using a Zetasizer Nano system from Malvern Instruments in their work on particulate vaccines formulations for administration via the respiratory tract.

Dr. Regina Scherließ leads the research group whose many recent publications include ‘PLGA nanoparticles for vaccine delivery to the respiratory tract and ‘Overcoming the challenges of nasal vaccines through intelligent particle engineering’.

“We formulate nanoparticles as antigen carriers and incorporate them into larger particles, known as nano-in-microparticles, or NiM, of a size feasible for deposition in the nose or lung,” explains Dr Scherließ.

Dr Scherließ continued, “We normally work with dry powder formulations, so the NiM will be dried, usually spray dried, at some point in the formulation process. As the particulate antigen carrier has to be taken up as a particle by the relevant immune cells, we mostly target dendritic cells and macrophages. Nanoparticle size is an important criterion for our formulations and we routinely measure this with the Zetasizer Nano.”

Particle size has to be measured directly after preparation and also upon redispersion of the NiM formulation. Redispersion often has to take place in physiological or cell culture media, and at this point the Zetasizer Nano is used to check for aggregates and particle size stability.

“We’ve also used the Zetasizer Nano for another project where we looked at stabilization of haemaglutinin during spray drying,” continued Dr Scherließ, “and as well in a project characterizing chitosan as an adjuvant. Here, we used the Zetasizer to determine the molecular weight of chitosans of different qualities.”

The Malvern Zetasizer range provides both exceptionally high performance and entry level systems that incorporate combinations of a particle size analyzer, zeta potential analyzer, molecular weight analyzer, protein mobility and microrheology measurements.

Particles and molecules from less than a nanometer in size to several microns can be analyzed by a range of variants to suit specific applications and budget.


Further Information
Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 2,400+ scientific posters on ePosters
  • More than 3,600+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.

Related Content

Malvern takes ACHEMA Visitors from R&D Through to Product QC
Visitors to the Malvern Instruments stand at ACHEMA 2012 will see how the company’s range of complementary materials characterization technologies and instrumentation support the needs of manufacturing industry.
Wednesday, March 28, 2012
Malvern Scientists will lead Protein Characterization Workshop at PEGS Summit
Drs Kevin Mattison, Ulf Nobbmann and Jason Sanchez will lead a workshop at the 7th Annual PEGS.
Tuesday, September 13, 2011
Scientific News
Researchers Develop Vaccine that Protects Primates Against Ebola
A collaborative team from The University of Texas Medical Branch at Galveston and the National Institutes of Health have developed an inhalable vaccine that protects primates against Ebola.
Universal Flu Vaccine in the Works
A new study has demonstrated a potential strategy for developing a flu vaccine with potent, broad protection.
Immunotherapy Shows Promise for Myeloma
A strategy, which uses patients’ own immune cells, genetically engineered to target tumors, has shown significant success against multiple myeloma, a cancer of the plasma cells that is largely incurable.
Ferring Bets on Bacteriophages to Treat Inflammatory Bowel Disease
Ferring Pharmaceuticals have annoucned that it will collaborate with Intralytix in the latest phase of its early stage development programme for a bacteriophage-based therapy for inflammatory bowel disease (IBD).
A Novel Drug to FIght Malaria
An international team of scientists has announced that a new compound to fight malaria is ready for human trials.
Ebola Vaccine Trial Begins in Senegal
A clinical trial to evaluate an Ebola vaccine has begun in Dakar, Senegal, after initial research started at the Jenner Institute, Oxford University.
New Cell Structure Finding Might Lead to Novel Cancer Therapies
University of Warwick scientists in the U.K. say they have discovered a cell structure which could help researchers understand why some cancers develop.
Cancer Discovery Links Experimental Vaccine and Biological Treatment
A new study at the University of Wisconsin-Madison has linked two seemingly unrelated cancer treatments that are both now being tested in clinical trials.
Study Reveals New Method to Develop More Efficient Drugs
A new study suggests a new approach to develop highly-potent drugs which could overcome current shortcomings of low drug efficacy and multi-drug resistance in the treatment of cancer as well as viral and bacterial infections.
Creating More Potent Vaccines
Yale researchers uncovered a new role for a type of immune cell, known as regulatory T cells, in promoting long-term immunity.
SELECTBIO

Skyscraper Banner
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
2,400+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
3,600+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FREE!