Corporate Banner
Satellite Banner
Cell Culture
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Evolutionary Molecule Identified by Researchers at University of Dundee

Published: Tuesday, August 07, 2012
Last Updated: Tuesday, August 07, 2012
Bookmark and Share
Scientists identified a molecule that could play a key role in how cells develop into the building blocks of life.

Developmental biologists try to understand how cells that are at first identical differentiate into the specialised cell types that make up tissues and organs.
 
Now researchers in the College of Life Sciences at Dundee, led by Professor Pauline Schaap, have identified a molecule called cyclic-di-GMP as being the `signal’ which can induce differentiation into stalk cells.
 
The Schaap laboratory studies a simple multicellular organism, Dictyostelium, in which motile cells (those which can move spontaneously) differentiate into two immobile cell types: stalk cells and spores.
 
In earlier research they showed that cyclic AMP induces the differentiation of spores. Now they have identified another molecule, cyclic-di-GMP, as the signal that induces the differentiation of stalk cells.
 
The new research is published in the journal Nature.
 
“Our work presents the opportunity to fully understand how cells learned to become different from each other in early multicellular organisms,” said Professor Schaap.
 
“These findings are also remarkable because cyclic-di-GMP was previously only found in bacteria, where it causes bacteria to lose motility and transform into large sticky colonies, known as biofilms. The fact that an organism like Dictyostelium, which is very far removed from bacteria, uses the same mechanism is very interesting and suggests that the processes which cause cell differentiation in eukaryotes, like ourselves, may have very deep evolutionary origins.”
 
The work has been funded by the Wellcome Trust and BBSRC, the Biotechnology and Biological Sciences Research Council.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,200+ scientific posters on ePosters
  • More than 4,800+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
A Novel Cell Culture Model For Forensic Biology Experiments
Researchers have developed a new cell culture model which provides an efficient research tool in forensic biology.
Mapping Zika’s Routes to Developing Fetus
UC researchers show how Zika virus travels from a pregnant woman to her fetus, and also identified a drug that could stop it.
3D Printing Cartilage
3D bioprinting has successfully manufactured cartilage using bioink sourced from cow cartilage strands.
New Device can Study Electric Field Cancer Therapy
Microfluidic device allows study of electric field cancer therapy through low-intensity fields, preventing malignant cells spreading.
Scientists Culture Elusive Yellowstone Microbe
ORNL scientists have successfully isolated and cultured a Yellowstone sourced acidic hot-spring based microbe.
A 3D Paper-Based Microbial Fuel Cell
Researchers have developed a proof-of-concept 3D paper-based microbial fuel cell (MFC) that could take advantage of capillary action to guide the liquids through the MFC system and to eliminate the need for external power.
Just Gellin’: How To Grow Strong Muscles-On-A-Chip
USC researchers hope to usher in new treatments for patients with muscular dystrophy.
Lasers Carve the Path to Tissue Engineering
A new technique, developed at EPFL, combines microfluidics and lasers to guide cells in 3D space, overcoming major limitations to tissue engineering.
How Cancer Spreads in the Body
Cancer cells appear to depend on an unusual survival mechanism to spread around the body, according to an early study led by Queen Mary University of London.
Tumor Cells Develop Predictable Characteristics
Scientists have discovered that cancer cells at the edge of a tumor that are close to the surrounding environment are predictably different from the cells within the interior of the tumor.
Skyscraper Banner

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,200+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
4,800+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!