Merck Millipore has launched Cellvento™ CHO-200 chemically defined cell culture medium, a product of non-animal origin that delivers robust cell growth and consistent high performance.
Accompanied by complementary Cellvento™ Feed products, the new medium is optimized specifically for fed-batch processes using CHO-S cell types expressing monoclonal antibodies.
Cellvento™ CHO-200 medium and its corresponding feeds do not contain hydrolysates or components of unknown composition, resulting in very good lot-to-lot consistency.
The formulation supports high cell density growth and extended culture duration as well as long duration of high cell viability. This facilitates the production of high protein titers and results in strong productivity and product quality.
Cellvento™ CHO-200 medium and Cellvento™ Feeds are produced in dry powder form at the company's cGMP facility, using fully traceable raw materials sourced from qualified suppliers, leading to reliable homogeneity that allows for effective powder dissolution and uniform component distribution. A liquid version of Cellvento™ CHO-200 medium will be introduced in the fall of 2013.
"The new Cellvento™ CHO-200 medium expands our existing CHO medium offerings, allowing us to fully support our customers as they switch to the production mode of operation," said Dr. Antoine Heron, Head of Biopharm Materials & Technologies.
Dr. Heron continued, "Our profiling and processing technologies for raw materials and cell culture media, which promote scalable and predictable performance, further differentiate Merck Millipore in the raw materials and cell culture media market. Combined with our deep expertise in regulatory requirements for pharmaceutical ingredients, we allow biopharmaceutical manufacturers to improve their process and increase their speed to market."