Corporate Banner
Satellite Banner
Cell Culture
Scientific Community
 
Become a Member | Sign in
Home>News>This Article
  News
Return

Alvetex 3D Cell Culture Scaffolds Chosen by Investigators at Massachusetts General Hospital

Published: Wednesday, July 31, 2013
Last Updated: Wednesday, July 31, 2013
Bookmark and Share
Scaffolds chosen for study of bone loss during space flight.

Reinnervate Ltd announced that its Alvetex®Scaffold system has been chosen by a group at Massachusetts General Hospital for the first ever 3D osteocytic cell culture experiments in microgravity.

Assistant Prof. of Medicine Paola Divieti Pajevic‟s group has been successfully using Alvetex®Scaffold to culture murine osteocytes in 3D to better mimic in-vivo growth conditions. Their long term aim is to understand the mechanisms of bone loss during unloading as occurs during prolonged bed rest, microgravity, or in diseases such as osteoporosis. The group has received funding from NIH and NASA to perform an experiment on the International Space Station in late 2014. This will expand their ongoing studies into the effects of bone loss during space flight. The group will culture osteocytes in bioreactors that will automate the process of feeding the cells during the ISS mission. This automatic system was specially designed by their implementation partners, CALM Technologies Inc.

„We are absolutely delighted that Alvetex Scaffold has been chosen for such an important and high profile project‟ said Prof. Stefan Przyborski, CSO and founder of Reinnervate. „3D cell culture is increasingly proving its worth in a wide variety of academic research areas. The ability to re-create more natural cellular structure, organisation and function in vitro is critical to advancing our understanding of basic cellular biology‟ he added.

Richard Rowling, commercial Director at Reinnervate added, „Dr. Divieti Pajevic‟s group looked at many different systems for 3D cell culture, but ultimately needed a simple product that is compatible with histology, to visualise cell structure and reliable recovery of total RNA to study gene expression profiles. Alvetex Scaffold was one of the few commercially available products that met all these criteria. We are really pleased that Alvetex®Scaffold is being used in such a fascinating project‟.

Dr. Divieti-Pajevic‟s group will continue to run experiments with Alvetex®Scaffold at her laboratory in the Endocrine Unit, Massachusetts General Hospital in the run up to the 2014 NASA mission. These experiments act as a control for normal gravitational conditions but also use the NASA developed rotating systems that aim to mimic micro-gravity. However, the go-ahead to run these studies on the ISS now offers the only real way to test their hypotheses.


Further Information

Join For Free

Access to this exclusive content is for Technology Networks Premium members only.

Join Technology Networks Premium for free access to:

  • Exclusive articles
  • Presentations from international conferences
  • Over 3,500+ scientific posters on ePosters
  • More than 5,000+ scientific videos on LabTube
  • 35 community eNewsletters


Sign In



Forgotten your details? Click Here
If you are not a member you can join here

*Please note: By logging into TechnologyNetworks.com you agree to accept the use of cookies. To find out more about the cookies we use and how to delete them, see our privacy policy.


Scientific News
New Therapeutic Target for Crohn’s Disease
A promising new target for drugs that treat IBD has been identified along with a possible biomarker for IBD severity.
Uncovering Water Bear Resilience
A protein identified in water bears can protect DNA of human cells from lethal doses of radiation damage.
Using Stem Cells to Grow a 3D Lung-in-a-Dish
Researchers have created 3D lung-like tissue from lung-derived stem cells. The tissue can be used to study lung diseases.
Reprogramming Lymph Nodes to Fight MS
Bioengineers work to reprogram lymph node function to fight multiple sclerosis.
Puttng Cells Through Their Paces
An obstacle course for human lung cells could be the answer for better testing the effectiveness of potential new drugs.
Inherited Heart Condition Breakthrough
Using stem cells, scientists have created a specific heart condition model, yeilding insights into unexpected disease mechanisms.
Genetic Tug of War Before Cells Decide Fate
Researchers report that as developing blood cells are triggered by genetic signals firing on and off, a 'tug of war' occurs.
Origin of Cultured Cells: Not Where You Think
Study shows cultured cells from decades-old cell line does not originate from the patient it was claimed to derive from.
Worms Point Way Toward Viral Strategies
Rice University wins NIH grant to study how nematodes handle gastrointestinal viruses.
Hope for Zika Treatment Found in Drug Screening
Johns Hopkins researchers join collaborative group to screen 6,000 existing drugs in hopes of finding treatments for Zika Virus infection.
SELECTBIO

SELECTBIO Market Reports
Go to LabTube
Go to eposters
 
Access to the latest scientific news
Exclusive articles
Upload and share your posters on ePosters
Latest presentations and webinars
View a library of 1,800+ scientific and medical posters
3,500+ scientific and medical posters
A library of 2,500+ scientific videos on LabTube
5,000+ scientific videos
Close
Premium CrownJOIN TECHNOLOGY NETWORKS PREMIUM FOR FREE!